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4-1BB

4-1BB 詳細

英語名	Tumor necrosis factor receptor superfamily member 9	市販薬剤の数	0
治験薬の数	78	ターゲットの別称	TNFRSF9，T-cell antigen ILA，ILA，TNF Receptor Superfamily Member 9，T-Cell Antigen 4-1BB Homolog，4-1BB Ligand Receptor，CD137 Antigen，CDw137，CD137，Interleukin-Activated Receptor， Homolog Of Mouse Ly63，Tumor Necrosis Factor Receptor Superfamily， Member 9，Tumor Necrosis Factor Receptor Superfamily Member 9，Induced By Lymphocyte Activation (ILA)，Homolog Of Mouse 4-1BB，Receptor Protein 4-1BB，T Cell Antigen ILA，4-1BB
研究＆開発段階	Phase 3 Clinical

英語名	Tumor necrosis factor receptor superfamily member 9
ターゲットの別称	TNFRSF9，T-cell antigen ILA，ILA，TNF Receptor Superfamily Member 9，T-Cell Antigen 4-1BB Homolog，4-1BB Ligand Receptor，CD137 Antigen，CDw137，CD137，Interleukin-Activated Receptor， Homolog Of Mouse Ly63，Tumor Necrosis Factor Receptor Superfamily， Member 9，Tumor Necrosis Factor Receptor Superfamily Member 9，Induced By Lymphocyte Activation (ILA)，Homolog Of Mouse 4-1BB，Receptor Protein 4-1BB，T Cell Antigen ILA，4-1BB
市販薬剤の数	0
治験薬の数	78
研究＆開発段階	Phase 3 Clinical

4-1BB 製品リスト

属性
Protein (20)Cell (2)Antibody (4)Kits (1)
製品ライブラリ
オンライン (27)
種
Human (19)Cynomolgus / Rhesus macaque (2)Mouse (3)Rabbit (1)Rat (1)Canine (1)
タグ
Fc Tag (4)His Tag (8)Mouse IgG Fc Tag (1)His Tag & Avi Tag (5)Fc Tag & Avi Tag (1)- (7)Tag Free (1)
マーカー
Unconjugated (17)Biotin-labeled (6)- (3)PE Labeled (1)

製品番号	種	発現システム	製品説明
HOT 41B-H5256	Human	HEK293	Human 4-1BB / TNFRSF9 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
HOT 41B-H5258	Human	HEK293	Human 4-1BB / TNFRSF9 Protein, Fc Tag, low endotoxin (MALS verified)
HOT 41B-H53H3	Human	CHO	Human 4-1BB / TNFRSF9 Protein, His Tag (MALS verified)
HOT 41B-H82E6	Human	HEK293	Biotinylated Human 4-1BB / TNFRSF9 Protein, His,Avitag™(MALS verified)
41B-CH25G1	Human	CHO	Monoclonal Anti-Human 4-1BB Antibody, Mouse IgG1, premium grade
41B-CH25GN	Human	CHO	Monoclonal Anti-Human 4-1BB Antibody, Mouse IgG1, Research Grade
41B-H5213	Human	HEK293	Human 4-1BB / TNFRSF9 Protein, Tag Free (MALS verified)
41B-H5253	Human	HEK293	Human 4-1BB / TNFRSF9 (87-186) Protein, Fc Tag (MALS verified)
41B-H52H3	Human	HEK293	Human 4-1BB / TNFRSF9 Protein, His Tag, Ultra Low Endotoxin (MALS verified)
41B-H52H9	Human	HEK293	Human 4-1BB / TNFRSF9 (24-86) Protein, His Tag

総数量27

4-1BBバックグランド

4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF2.

4-1BB分子の別称

TNFRSF9,4-1BB,CD137,CDw137,ILA

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Utomilumab	PF-05082566; PF-2566; PF-5082566	Phase 3 Clinical	Pfizer Inc	Bone metastases; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Head and Neck Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Melanoma; Neoplasms; Oropharyngeal Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms	詳細
Urelumab	BMS-66513; BMS-663513	Phase 2 Clinical	Bristol-Myers Squibb Company	Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Colorectal Neoplasms; Glioblastoma; Gliosarcoma; Head and Neck Neoplasms; Leukemia; Leukemia, B-Cell; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Melanoma; Multiple Myeloma; Neoplasms; Skin Melanoma; Skin Neoplasms; Solid tumours; Urinary Bladder Neoplasms	詳細
ALG.APV-527	ALG.APV 527; ADC-1016; ATOR-1016; ALG.APV-527; ALG-APV-527	Phase 2 Clinical	Alligator Bioscience Ab, Aptevo Therapeutics Inc	Neoplasms; Solid tumours	詳細
PE-0116	PE-0116	Phase 2 Clinical	Shanghai HyaMab Biotech Co Ltd	Solid tumours	詳細
Delolimogene mupadenorepvec	LOAd-703	Phase 2 Clinical	Lokon Pharma, Uppsala University	Biliary Tract Neoplasms; Colorectal Neoplasms; Melanoma; Ovarian Neoplasms; Pancreatic Neoplasms	詳細
AGEN-2373	AGEN-2373	Phase 2 Clinical	Agenus Inc	Neoplasms; Pancreatic Neoplasms	詳細
ADG-106	ADG106; ADG-106	Phase 2 Clinical	Adagene (Suzhou) Ltd	Lymphoma, Non-Hodgkin; Solid tumours	詳細
Cinrebafusp alfa	PRS-343	Phase 2 Clinical	Pieris Pharmaceuticals	Breast Neoplasms; Solid tumours; Stomach Neoplasms; Urinary Bladder Neoplasms	詳細
CTX-471	CTX-471	Phase 2 Clinical	Compass Therapeutics LLC	Carcinoma, Non-Small-Cell Lung; Glioblastoma; Head and Neck Neoplasms; Melanoma; Mesothelioma; Neoplasm Metastasis; Neoplasms; Small Cell Lung Carcinoma; Solid tumours	詳細
Tecaginlimab	BNT-312; GEN-1042	Phase 2 Clinical	Genmab A/S	Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck	詳細
AP-203	AP-203; AP203	Phase 2 Clinical	AP Biosciences Inc	Carcinoma, Non-Small-Cell Lung; Esophageal Squamous Cell Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck	詳細
BOS-342	PRS-342; BOS-342; PRS-342/BOS-342	Phase 2 Clinical	Pieris Pharmaceuticals	Carcinoma, Hepatocellular; Solid tumours	詳細
ABL-104	ABL-104; YH-32364	Phase 2 Clinical	Abl Bio Inc	Colorectal Neoplasms; Head and Neck Neoplasms; Solid tumours	詳細
ABL-103	ABL-103	Phase 2 Clinical	Abl Bio Inc, Handok Inc	Solid tumours	詳細
Nesfrotamig	ABL105; YH-32367	Phase 2 Clinical	Abl Bio Inc	Breast Neoplasms; Solid tumours; Stomach Neoplasms	詳細
BT-7480	BT-7480	Phase 2 Clinical	Bicycle Therapeutics	Neoplasms; Solid tumours	詳細
BAT-7111	BAT7111; BAT-7111	Phase 2 Clinical	Bio-Thera Solutions Ltd	Solid tumours	詳細
Exlinkibart	LVGN-6051	Phase 2 Clinical	Lyvgen Biopharma(HK)Ltd	Carcinoma, Hepatocellular; Esophageal Neoplasms; Head and Neck Neoplasms; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Papillomavirus Infections; Sarcoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Uveal melanoma	詳細
LM-2417	LM-2417; LM2417	Phase 2 Clinical	LaNova Medicines Ltd	Solid tumours	詳細
DSP-107	KAHR-107; DSP-107	Phase 2 Clinical	Kahr Medical	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Solid tumours	詳細
DuoBody-EpCAMx4-1BB	BNT314/GEN1059; GEN-1059; GEN1059; BNT314	Phase 2 Clinical	Biontech Se, Genmab A/S	Colorectal Neoplasms; Neoplasms; Solid tumours	詳細
LM-24C5	LM-24C5	Phase 2 Clinical	LaNova Medicines Ltd	Neoplasms; Solid tumours	詳細
IBD-0333	IBD-0333; IBD0333	Phase 2 Clinical	SunHo (China) BioPharmaceutical Co Ltd	Lymphoma, Non-Hodgkin; Neoplasms; Solid tumours	詳細
PRS-344	PRS-344S095012; S-095012; S-95012; PRS-344/ONC0055; PRS-344; PRS-344/S095012	Phase 2 Clinical	Pieris Pharmaceuticals Inc	Solid tumours	詳細
HK-010	HK-010; HK010	Phase 2 Clinical	Anhui Anke Biotechnology (Group) Co Ltd, Hefei Hankemab Biotechnology Co Ltd	Neoplasms; Solid tumours	詳細
Emfizatamab	GNC-038	Phase 2 Clinical	Sichuan Baili Pharmaceutical Co Ltd, SystImmune	Arthritis, Rheumatoid; Central Nervous System Lymphoma; Lupus Erythematosus, Systemic; Lymphoma, Extranodal NK-T-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours	詳細
ARI-0002h	ARI-0002h	Phase 2 Clinical	Instituto De Salud Carlos Iii	Multiple Myeloma	詳細
PM-1032	PM1032; PM-1032	Phase 2 Clinical	Shanghai Genechem Co Ltd	Neoplasms; Pancreatic Neoplasms	詳細
Englumafusp alfa	RG-6076; RO-7227166	Phase 2 Clinical	F. Hoffmann-La Roche Ltd	Lymphoma, B-Cell; Lymphoma, Non-Hodgkin	詳細
Opamtistomig	LBL-024; LBL024	Phase 2 Clinical	Nanjing Leadsbiolabs Co Ltd	Carcinoma, Neuroendocrine; Melanoma; Neoplasms; Ovarian Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	詳細
QLF31907	QLF31907; QLF-31907	Phase 2 Clinical	Qilu Pharmaceutical Co Ltd	Carcinoma, Transitional Cell; Lymphoma, Non-Hodgkin; Melanoma; Neoplasms; Solid tumours	詳細
EU-101	EU-101; NOV-1801	Phase 2 Clinical	Eutilex	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Prostatic Neoplasms; Solid tumours	詳細
Nebratamig	GNC-035	Phase 2 Clinical	Sichuan Baili Pharmaceutical Co Ltd	Breast Neoplasms; Hematologic Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Metastatic breast cancer; Solid tumours	詳細
Givastomig	TJ-CD4B; ABL-111; TJ-CLDN4B; TJ-033721; TJ-CD4B/ABL111	Phase 2 Clinical	I-Mab Biopharma Co Ltd	Biliary Tract Neoplasms; Carcinoma, Pancreatic Ductal; Esophageal adenocarcinoma; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Neoplasm Metastasis; Neoplasms; Solid tumours; Stomach Neoplasms	詳細
Prizloncabtagene autoleucel	JNJ-4496; EXP-039; C-CAR039; C-CAR-039; C CAR 039; EXP0-039; JNJ-90014496	Phase 2 Clinical	Cellular Biomedicine Group Ltd	Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin	詳細
PM-1003	PM1003	Phase 2 Clinical		Solid tumours	詳細
FS-120	FS-120	Phase 1 Clinical	F-Star	Neoplasm Metastasis; Neoplasms	詳細
MCLA-145	MCLA-145	Phase 1 Clinical	Incyte Corp, Merus Nv	Lymphoma, B-Cell; Neoplasms; Solid tumours	詳細
CD137/FAP bispecific agonist antibody (Boehringer Ingelheim International)		Phase 1 Clinical	Boehringer Ingelheim International Gmbh	Neoplasms	詳細
AP-601	AP-601	Phase 1 Clinical	AP Biosciences Inc	Neoplasms; Solid tumours	詳細
BH-3120	BH-3120	Phase 1 Clinical	Hanmi Pharmaceutical Co Ltd	Solid tumours	詳細
Xirestomig	ATG-101; ATG101; YN051	Phase 1 Clinical	The Origin Cell Technology Group Co Ltd	Hematologic Neoplasms; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Solid tumours	詳細
QL-301	QL-301	Phase 1 Clinical	Qlsf Biotherapeutics Inc	Neoplasms	詳細
MP-0310	MP-0310; AMG-506	Phase 1 Clinical	Amgen Inc, Molecular Partners Ag	Solid tumours	詳細
YH-004(Hangzhou Yuhong Medical Tech)	YH-004	Phase 1 Clinical	Hangzhou Yuhong Medical Technology Co Ltd	Acute Kidney Injury	詳細
hTERT-induced natural T cells therapy(Eutilex)		Phase 1 Clinical	Eutilex	Solid tumours	詳細
BGB-B2033	BGB-B-2033; BGB-B2033	Phase 1 Clinical	Beigene Guangzhou Biologics Manufacturing Co Ltd	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Neoplasms; Solid tumours; Stomach Neoplasms	詳細
BHP-01	BHP-01; BHP01; α-PD-L1/4-1BB DLL3 CAR-T	Phase 1 Clinical	Chengdu Brilliant Pharmaceutical Co Ltd	Small Cell Lung Carcinoma	詳細
ND-021	ND-021; NM21-1480; CS-2006; CS2006	Phase 1 Clinical	Cstone Pharmaceuticals, Numab Therapeutics Ag	Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Squamous Cell; Colorectal Neoplasms; Fallopian Tube Neoplasms; Neoplasms; Peritoneal Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms	詳細
FTL-008.16	FTL-008.16; FTL008.16	Phase 1 Clinical	Sound(Chengdu)Biopharmacauticals Co Ltd	Solid tumours	詳細
NBL-028	NBL028; NBL-028	Phase 1 Clinical	Novarock Biotherapeutics Ltd, Shanghai Xinshi Biological Medicine Co Ltd	Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Neoplasms; Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Testicular Neoplasms	詳細
SAIL-66	SAIL66; SAIL-66	Phase 1 Clinical	Chugai Pharmaceutical Co Ltd	Solid tumours	詳細
BC 3425	BC-3425	Phase 1 Clinical	Wuxi BioCity	Solid tumours	詳細
ASP1002	ASP-1002; ASP1002	Phase 1 Clinical	Astellas Pharma Global Development Inc	Solid tumours	詳細
RG-6524	RO-7616789; ALPS-12; RG6524	Phase 1 Clinical	F. Hoffmann-La Roche Ag	Carcinoma, Neuroendocrine; Small Cell Lung Carcinoma	詳細
SGN-BB228	SGN-BB228; PF-08046049; BB-228; PRS-346	Phase 1 Clinical	Pieris Pharmaceuticals	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Melanoma; Mesothelioma; Pancreatic Neoplasms; Skin Melanoma; Solid tumours	詳細
Ori-Bs-001	Ori-Bs-001	Phase 1 Clinical	OriCell Therapeutics Co Ltd	Solid tumours	詳細
IMB-071703	IMB-071703; IMB071703	Phase 1 Clinical	Beijng Immunoah Pharma Tech Co Ltd	Solid tumours	詳細
ADG-206	ADG-206	Phase 1 Clinical	Adagene (Suzhou) Ltd	Neoplasms; Solid tumours	詳細
TJ-C64B	TJ-C64B	Phase 1 Clinical	I-Mab Biopharma Co Ltd	Ovarian Neoplasms; Stomach Neoplasms	詳細
ZG-033	ZG033; HK-003	Phase 1 Clinical	Hefei Hankemab Biotechnology Co Ltd	Neoplasms	詳細
STA-551	STA-551	Phase 1 Clinical	Chugai Pharmaceutical Co Ltd	Solid tumours	詳細
FS222 mAb² (F-star Therapeutics)	FS-222	Phase 1 Clinical	F-star Beta Ltd	Neoplasm Metastasis; Neoplasms; Solid tumours	詳細
FTL-001	FTL001; FTL-001	Phase 1 Clinical	Sound(Chengdu)Biopharmacauticals Co Ltd, Xikang (Wuhan) Biomedicine Co Ltd	Solid tumours	詳細
BI-765179	BI-765179	Phase 1 Clinical	Boehringer Ingelheim International Gmbh	Neoplasms; Squamous Cell Carcinoma of Head and Neck	詳細
DF-003(Dingfu Biotarget)	DF-003	Phase 1 Clinical	Dingfu Biotarget Co Ltd	Lymphoma, Non-Hodgkin; Solid tumours	詳細
CB-307	CB-307; CB307	Phase 1 Clinical	Crescendo Bioscience Inc	Neoplasms; Prostatic Neoplasms, Castration-Resistant	詳細
RO-7122290	RO-7122290; RG-7827	Phase 1 Clinical	F. Hoffmann-La Roche Ltd	Colorectal Neoplasms	詳細
Ragistomig	ABL-503; TJ-L14B/ABL503; ABL503; TJ-L14B	Phase 1 Clinical	I-Mab Biopharma Co Ltd	Solid tumours	詳細
HLX-35	HLX-35; BNA035	Phase 1 Clinical		Carcinoma, Non-Small-Cell Lung; Solid tumours	詳細
GNC-039	GNC-039	Phase 1 Clinical	Sichuan Baili Pharmaceutical Co Ltd	Glioma; Hematologic Neoplasms; Neoplasm Metastasis; Solid tumours	詳細
HBM-7008	HBM7008; HBM-7008; R-7008; CLN-418	Phase 1 Clinical	Harbour Biomed	Solid tumours	詳細
IBI-319	IBI-319	Phase 1 Clinical		Neoplasms	詳細
YH-004	YH-004	Phase 1 Clinical		Lymphoma, Non-Hodgkin; Neoplasms; Solid tumours	詳細
HOT-1030	HOT-1030	Phase 1 Clinical	HuaBo Biopharm Co Ltd	Solid tumours	詳細
QL-1806	QL-1806	Phase 1 Clinical	Qilu Pharmaceutical Co Ltd	Neoplasms	詳細
Cedarizumab		Phase 1 Clinical	Therawisdom Biopharma Co Ltd	Carcinoma, Transitional Cell; Melanoma; Solid tumours	詳細
Evunzekibart	ATOR-1017	Phase 1 Clinical	Alligator Bioscience Ab	Neoplasms; Solid tumours	詳細

レビュー

유***진2026-04-21
0評価
Human 4-1BB / TNFRSF9 Protein, His Tag, low endotoxin (MALS verified)
I purchased ACRO’s Human 4-1BB (His Tag) for our recent binding affinity studies. The most impressive aspect was the provided MALS (Multi-Angle Light Scattering) data, which gave us high confidence in the protein's oligomeric state and purity before even starting our experiments. Since 4-1BB function is highly dependent on its structural integrity, having MALS-verified molecular weight data is a huge advantage. We observed excellent consistency in our SPR (Surface Plasmon Resonance) assays with minimal lot-to-lot variation. Highly recommended for researchers requiring high-precision analytical data.
M***i2023-03-21
1評価
Human 4-1BB / TNFRSF9 Protein, His Tag, low endotoxin (MALS verified)
I have ordered this material several times for use in Biacore/SPR assays. I have been able to obtain consistent, high-quality results with different lots of this antigen and was able to reproduce kinetic measurements reported in literature for commercial anti-4-1BB molecules. Because 4-1BB is glycosylated, the molecular weight reported by SEC-MALS is helpful for estimating Rmax for my experiments. We have also used this antigen to successfully capture anti-4-1BB out of serum in ELISAs.