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ACHE

ACHE 詳細

英語名	Acetylcholinesterase	市販薬剤の数	27
治験薬の数	31	ターゲットの別称	EC:3.1.1.7，EC 3.1.1，Acetylcholinesterase (YT Blood Group)，Acetylcholinesterase (Cartwright Blood Group)，Yt Blood Group，Apoptosis-Related Acetylcholinesterase，Acetylcholinesterase，EC 3.1.1.7，ARACHE，N-ACHE，ACEE，AChE，YT
研究＆開発段階	Approved

英語名	Acetylcholinesterase
ターゲットの別称	EC:3.1.1.7，EC 3.1.1，Acetylcholinesterase (YT Blood Group)，Acetylcholinesterase (Cartwright Blood Group)，Yt Blood Group，Apoptosis-Related Acetylcholinesterase，Acetylcholinesterase，EC 3.1.1.7，ARACHE，N-ACHE，ACEE，AChE，YT
市販薬剤の数	27
治験薬の数	31
研究＆開発段階	Approved

ACHE 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
His Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
AHE-H52H3	Human	HEK293	Human ACHE / Acetylcholinesterase Protein, His Tag (active enzyme)

総数量1

ACHEバックグランド

The enzyme acetylcholinesterase, also known as AChE or acetylhydrolase, is the primary cholinesterase in the body. It is a serine hydrolase whose primary function is to catalyzes the breakdown of acetylcholine(ACh) and of some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. Acetylcholine deficit has been found in Alzheimer's disease (AD) ans is associated with cognetive decline. Therefore, AChE has been reported to be a viable therapeutic target for the treatment of AD and other dementias. To this end, acetylcholinesterase inhibitors (AChEIs) are commonly used.

ACHE分子の別称

acetylcholinesterase (Yt blood group),Acetylcholinesterase,ACHE,apoptosis-related acetylcholinesterase,ARACHE,EC 3.1.1,EC 3.1.1.7,N-ACHE,Yt blood group,YT

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Donepezil/Solifenacin	CPC-201	Phase 3 Clinical	Allergan Plc, Cipla Inc	Alzheimer Disease; Dementia; Urologic Diseases	詳細
Botulinum toxin (CKD Bio)	CKDB-501B; CKDB-501-B; CKDB-501A; CKDB-501-A; CKDB-501	Phase 3 Clinical	CKD Bio Corp	Glabellar lines; Spasm	詳細
BR-4001	BNT-002; BR-4001	Phase 3 Clinical	Boryung Pharmaceutical Co Ltd	Alzheimer Disease	詳細
Blarcamesine/Donepezil Hydrochloride		Phase 2 Clinical	Anavex Life Sciences Corp	Alzheimer Disease	詳細
Pregnenolone	NBI-113	Phase 2 Clinical	Neurocrine Biosciences Inc	Alcoholism; Anxiety; Autism Spectrum Disorder; Autistic Disorder; Cocaine-Related Disorders; Depression; Depressive Disorder, Major; Low Back Pain; Menopausal symptoms; Schizophrenia; Stress Disorders, Post-Traumatic	詳細
Fluoropezil	DC-20; DC-511020	Phase 2 Clinical	Jiangsu Kanion Pharmaceutical Co Ltd, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences	Alzheimer Disease	詳細
Pyridostigmine extended release (Kashiv BioSciences)	K-127	Phase 2 Clinical	Kashiv BioSciences LLC	Blepharoptosis; Fatigue Syndrome, Chronic; Musculoskeletal Diseases; Myasthenia Gravis; Post-Acute COVID-19 Syndrome; Urination Disorders	詳細
Donepezil long-acting Injection (Inventage Lab)	IVL-3003	Phase 2 Clinical	Inventage Lab Inc	Alzheimer Disease	詳細
YY-003	YY003; YY-003	Phase 2 Clinical	Chongqing Claruvis Pharmaceutical Co Ltd	Glabellar lines	詳細
AT-004(Arctic Therapeutics)	AT-004(Arctic Therapeutics)	Phase 2 Clinical	Arctic Therapeutics International	Acne Vulgaris; Dermatitis, Atopic; Psoriasis; Rosacea	詳細
Galantamine/Metformin	RJx-01	Phase 2 Clinical	Rejuvenate Biomed NV	Muscle Weakness; Muscular Atrophy; Sarcopenia	詳細
Huperizine-A (Biscayne Pharmaceuticals)	BIS-001; INS-001; XEL-001-HP; SPN-817; BIS-001-ER; XEL-001-HG; Hup-A	Phase 2 Clinical	Harvard University	Epilepsy, Complex Partial; Seizures	詳細
EX-039	EX-039	Phase 2 Clinical	Excelsior Corp	Alzheimer Disease	詳細
donepezil (Vyant Bio)	VYNT-0126	Phase 2 Clinical	Vyant Bio Inc	Rett Syndrome	詳細
YIV-906	PHY-906; KD-018	Phase 2 Clinical	Phytoceutica Inc	Carcinoma, Hepatocellular; Colorectal Neoplasms; Diarrhea; Hepatitis B; Liver Neoplasms; Pancreatic Neoplasms; Rectal Neoplasms	詳細
AD-35	AD-35	Phase 2 Clinical	Zhejiang Hisun Pharmaceutical Co Ltd	Alzheimer Disease	詳細
Edrophonium Chloride		Phase 1 Clinical	Teligent	Myasthenia Gravis	詳細
18F-flubatine	Fluorine-18-flubatine; flubatine-[18F]; 18F-flubatine; norchloro-fluoroepibatidine-[18F]	Phase 1 Clinical	Helmholtz-Zentrum Dresden-Rossendorf	Alzheimer Disease	詳細
Phenserine tartrate	DWJ301	Phase 1 Clinical	Qr Pharma	Alzheimer Disease; Cognitive Dysfunction	詳細
Mecripyrine Hydrochloride	SCR-1693; Y-1A; Y-1	Phase 1 Clinical	Jiangsu Simcere Pharmaceutical Co Ltd, NeuroDawn Pharmaceutical Co Ltd, Yantai Yene Pharma Co Ltd	Alzheimer Disease; Brain Neoplasms	詳細
Methanesulfonyl fluoride	SNX-001	Phase 1 Clinical	Senexta	Alzheimer Disease	詳細
NB-02	NB-02; DA-9803	Phase 1 Clinical	Dong-A ST Co Ltd	Alzheimer Disease; Lymphoma, Non-Hodgkin	詳細
NDC-011	NDC-011	Phase 1 Clinical	Dr. Noah Biotech Inc	Amyotrophic Lateral Sclerosis	詳細
Donepel hydrochloride oral instant membrane(Sichuan Baili Pharma)		Phase 1 Clinical	Sichuan Baili Pharmaceutical Co Ltd	Alzheimer Disease	詳細
Donepezil Hydrochloride Oral Soluble Film(Shanxi Hcxf Pharma)		Phase 1 Clinical	Shanxi Hcxf Pharmaceutical Co Ltd	Alzheimer Disease	詳細
Donepezil Hydrochloride Oral Soluble Film(Hangzhou Heze Pharma)	HZ007; HZ-007	Phase 1 Clinical	Hangzhou Heze Pharmaceutical Technology Co Ltd	Alzheimer Disease; Dementia	詳細
Huperzine A Oral Solution(Universal Pharmaceutical Group)		Phase 1 Clinical	Universal Pharmaceutical Group Co Ltd	Myasthenia Gravis	詳細
Donepezil transdermal patch（Dong-A ST）	DA-5207	Phase 1 Clinical	Dong-A ST Co Ltd		詳細
HHT-201	HHT-201	Phase 1 Clinical	Zhejiang Huahai Pharmaceutical Co Ltd	Alzheimer Disease; Hypertension	詳細
Rivastigmine (Lachesis Biosciences Pty)		Clinical	Lachesis Biosciences Pty Ltd	Nerve Degeneration	詳細
donepezil (Daewoong)	DWJ-1365	Clinical	Daewoong Pharmaceutical Co Ltd	Alzheimer Disease	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Galantamine Hydrobromide	GP-37267; R-113675	Approved		AverTox, Nivalin, Reminyl, Razadyne, Reminyl XL	Mainland China	Alzheimer Disease	null	1981-01-01	AIDS Dementia Complex; Alzheimer Disease; Autistic Disorder; Bipolar Disorder; Brain Diseases; Cocaine-Related Disorders; Cognition Disorders; Dementia; Dementia, Vascular; Depressive Disorder, Major; Fasting; Frontotemporal Dementia; Insulin Resistance; Lewy Body Disease; Memory; Mental Disorders; Nervous System Diseases; Obesity; Schizophrenia; Stroke; Subarachnoid Hemorrhage; Tobacco Use Disorder; Vascular Diseases	詳細
Neostigmine Bromide		Approved		Prostigmin	Mainland China	Flatulence; Urinary Retention; Myasthenia Gravis	Shanghai Sine Pharmaceutical Laboratories Co Ltd	1995-01-01	Delayed Emergence from Anesthesia; Flatulence; Headache; Hypertension; Hyperventilation; Hypoxia; Myasthenia Gravis; Tachycardia; Urinary Retention	詳細
Metrifonate	Bay-a-9826; Bayer-L-1359	Approved		ProMem, Memobay, Bilarcil					Schistosomiasis	詳細
Rivastigmine Tartrate	SDZ-212-713; SDZ 212713; SDZ-ENA-713; ONO-2540; ENA-713; ENA-713D	Approved	Novartis Pharma Ag	Exelon TDS, Rivastach, Exelon MR, Prometax, Exelon, 艾斯能	EU	Alzheimer Disease; Parkinson Disease; Dementia	Novartis Europharm Ltd	1998-05-11	Alzheimer Disease; Anticholinergic Syndrome; Brain Injuries, Traumatic; Cocaine-Related Disorders; Cognition Disorders; Delirium; Dementia; Dementia, Vascular; Down Syndrome; Neurobehavioral Manifestations; Parkinson Disease; Substance-Related Disorders	詳細
Pyridostigmine Bromide	Ro-1-5130	Approved	Valeant	Regonol, Mestinon	United States	Lambert-Eaton Myasthenic Syndrome	Bausch & Lomb (Singapore) Pvi Ltd	1955-04-06	Colonic Diseases; Constipation; Coronavirus Disease 2019 (COVID-19); Diabetes Mellitus; Dyskinesias; Fatigue Syndrome, Chronic; Fibromyalgia; Glycogen Storage Disease Type II; Heart Failure; HIV Infections; Hypotension, Orthostatic; Immunologic Deficiency Syndromes; Lambert-Eaton Myasthenic Syndrome; Myasthenia Gravis; Parkinson Disease; Poisoning; Postural Orthostatic Tachycardia Syndrome; Primary Dysautonomias; Scleroderma, Systemic; T-Lymphocytopenia, Idiopathic CD4-Positive	詳細
Dimebolin hydrochloride	BRN-0622478; PF-01913539; DMB-I	Approved	Bigespas Ltd	Dimebon	Russian Federation	Hypersensitivity; Rhinitis, Allergic; Dermatitis, Atopic	null	1983-01-01	Alzheimer Disease; Dementia; Dermatitis, Atopic; Huntington Disease; Hypersensitivity; Liver Failure; Rhinitis, Allergic	詳細
Donepezil Hydrochloride	DKF-310; BNAG; E-2020; E-2022; (±)-E-2020; IVL-3003; GB-5001	Approved	Eisai Co Ltd	Memac, Eranz, Memorit, Aricept Evess, Aricept, Aricept ODT, Aricept D, 安理申, ADLARITY	United States	Alzheimer Disease	Eisai Inc	1996-11-25	Alcoholism; Alzheimer Disease; Anorexia Nervosa; Anxiety Disorders; Aphasia; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Autistic Disorder; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Central Nervous System Neoplasms; CNS Embryonal Tumor; Cognition Disorders; Cognitive Dysfunction; Delirium; Dementia; Dementia, Vascular; Depression; Diabetes Mellitus, Type 2; Down Syndrome; Fatigue; Fragile X Syndrome; Hearing Loss, Sensorineural; Ischemic Stroke; Lewy Body Disease; Memory Disorders; Migraine Disorders; Multiple Sclerosis; Neoplasms; Neurologic Manifestations; Neurotoxicity Syndromes; Osteoporosis; Parkinson Disease; Psychological Distress; Sleep Wake Disorders; Stroke; Subarachnoid Hemorrhage; Supranuclear Palsy, Progressive; Wounds and Injuries	詳細
Memantine Hydrochloride/Donepezil Hydrochloride	ADS-8704; D-797/D-324; CKD 355; BPS-034; BPDO-1603; MDX-8704	Approved	Allergan Plc	Arimenda, Namzaric	United States	Alzheimer Disease	Abbvie Inc	2014-12-23	Alzheimer Disease	詳細
Huperzine A	SPN-817	Approved	Chinese Academy Of Sciences, Mayo Clinic	哈伯因, 双益平	Mainland China	Alzheimer Disease	Henan Taloph Pharmaceutical Stock Co Ltd	1994-01-01	Alzheimer Disease; Brain Injuries, Traumatic; Epilepsy; Learning Disabilities; Memory Disorders; Schizophrenia; Seizures	詳細
Distigmine Bromide	BC-51	Approved	Torii Pharmaceutical Co Ltd	Ubretid	Japan	Dysuria; Myasthenia Gravis	Torii Pharmaceutical Co Ltd	1967-09-05	Dysuria; Esotropia; Glaucoma; Myasthenia Gravis	詳細
Pralidoxime Chloride	2-PAM-chloride	Approved	Baxter International Inc	Protopam chloride	United States	Poisoning	Baxter Healthcare Corp	1964-03-11	Poisoning	詳細
Pralidoxime Iodide	2-PAMI; NSC-7760; 2-PAM Iodide	Approved			Japan	Poisoning	Sumitomo Dainippon	1958-05-01	Poisoning	詳細
Eserine Salicylate		Approved		Synapton SR, Xalieve, Antilirium					Delirium; Glaucoma; Insulin Resistance; Pain, Postoperative; Psychotic Disorders	詳細
Neostigmine methylsulfate		Approved		Bloxiverz, Intrastigmina, Juvastigmin, Stiglyn, Metastigmin	Japan	Myasthenia Gravis; Muscle Hypotonia	kyowayakuhin Co	1936-10-01	Flatulence; Muscle Hypotonia; Myasthenia Gravis; Neuromuscular Blockade; Urinary Retention	詳細
Naphazoline Hydrochloride/Neostigmine methylsulfate/Glycyrrhizinate dipotassium/Chlorphenamine Maleate/Aspartic Acid/Vitamin B6		Approved		新乐敦						詳細
Dextrose/Sodium Chloride/Potassium Chloride/Floxacillin sodium		Approved								詳細
Dextrose/Sodium Chloride/Potassium Chloride/Anthralin		Approved								詳細
Dextrose/Sodium Chloride/Potassium Chloride/Pralidoxime Chloride		Approved								詳細
Pralidoxime Chloride/Benactyzine Hydrochloride/Atropine Sulfate		Approved							Poisoning	詳細
Naphazoline Hydrochloride/Neostigmine methylsulfate		Approved								詳細
Dihydrogalanthamine Hydrobromide		Approved			Mainland China	Hemiplegia; Sciatica	null	1982-01-01	Hemiplegia; Sciatica	詳細
Securinine Nitrate		Approved							Facial Paralysis; Poliomyelitis	詳細
Rivastigmine Twice Weekly Transdermal Patch (Luye Pharma)	LY-03013; LY-30410; RID-TDS	Approved	Acino International AG	Rivirec, 金斯明, Kingsmin, Rivalif®	Mainland China	Alzheimer Disease	Luye Pharma Group Ltd		Alzheimer Disease; Parkinson Disease	詳細
Glycopyrronium bromide/Neostigmine metilsulfate		Approved	Sintetica Gmbh	Novistig, Prevduo	Austria	Neuromuscular Blockade	Sintetica Gmbh	2020-09-23	Neuromuscular Blockade	詳細
Benzgalantamine gluconate	GLN-1062; ALPHA-1062; ALPHA-1062IN; Alpha 1062; ALPHA-1062 Intranasal	Approved	Galantos Pharma GmbH	Zunveyl	United States	Alzheimer Disease	Alpha Cognition Inc	2024-07-26	Alzheimer Disease; Brain Injuries, Traumatic; Cognitive Dysfunction	詳細
Atropine/Pralidoxime Chloride		Approved	Meridian Medical Technologies Inc	DUODOTE	United States	Poisoning; Organophosphate Poisoning	Meridian Medical Technologies LLC	2002-01-17	Drug intoxications; Drug-Related Side Effects and Adverse Reactions; Organophosphate Poisoning; Poisoning	詳細
Acotiamide Hydrochloride Hydrate	Z-338; YM-443	Approved	Zeria	Acofide	Japan	Dyspepsia	null	2013-03-25	Dyspepsia; Nausea	詳細