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Activin RIA

Activin RIA 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
Fc Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
ACA-H5254	Human	HEK293	Human Activin RIA Protein, Fc Tag (MALS verified)

総数量1

Activin RIAバックグランド

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
AV-001	AV-001	Phase 2 Clinical	Vasomune Therapeutics Inc	Respiratory Tract Infections; Pneumonia; Coronavirus Disease 2019 (COVID-19); Respiratory Distress Syndrome, Adult; Pneumonia, Viral	詳細
Rebastinib Tosylate	DP-1919; DCC-2036; DP-1919.TO	Phase 2 Clinical	Deciphera	Leukemia, Myelogenous, Chronic; Solid tumours	詳細
Razuprotafib	AKB-9778	Phase 2 Clinical	Akebia Therapeutics Inc	Coronavirus Disease 2019 (COVID-19); Respiratory Distress Syndrome, Adult; Glaucoma, Open-Angle; Ocular Hypertension; Diabetic macular oedema; Diabetic Retinopathy; Retinal Vein Occlusion	詳細
Merestinib	5OGS5K699E; LY-2801653	Phase 2 Clinical	Eli Lilly And Company	Biliary Tract Neoplasms; Skin Melanoma; Bone metastases; Solid tumours; Neoplasms; Pancreatic Neoplasms; Microsatellite instability-high cancer; Lymphoma, Mantle-Cell; Breast Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Gallbladder Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung	詳細
Glesatinib	MGCD-265; MG-90265X; 7Q29OXD98N; MG-90265H9; MG-90265gly; MG-90265	Phase 2 Clinical		Neoplasms; Carcinoma, Non-Small-Cell Lung	詳細
Trebananib	AMG-386; 20060439	Phase 2 Clinical	Amgen Inc, Takeda Pharmaceutical Co Ltd	Fallopian Tube Neoplasms; Carcinoma, Adenosquamous; Sarcoma; Breast Neoplasms; Brain Neoplasms; Prostatic Neoplasms; Peritoneal Neoplasms; Gliosarcoma; Genital Neoplasms, Female; Colorectal Neoplasms; Endometrial Neoplasms; Adenocarcinoma, Clear Cell; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Lung Neoplasms; Uterine Neoplasms; Carcinoma, Endometrioid; Neoplasm Metastasis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Neoplasms; Glioblastoma; Ovarian Neoplasms; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Carcinoma, Renal Cell; Renal Insufficiency; Hemangiosarcoma; Rectal Neoplasms; Carcinoma; Leukemia, Myelomonocytic, Acute; Solid tumours; Carcinoma, Transitional Cell; Neoplasms; Colonic Neoplasms; Kidney Diseases; Sarcoma, Endometrial Stromal; Leukemia, Megakaryoblastic, Acute; Oligodendroglioma; Central Nervous System Neoplasms; Neuroendocrine Tumors	詳細
Gersizangitide	AXT-107	Phase 2 Clinical	AsclepiX Therapeutics Inc	Macular Edema; Diabetic macular oedema; Macular Degeneration	詳細
CEP-11981	ESK-981; CEP-11981; SSR-106462; BOL-303213X	Phase 2 Clinical	Sanofi	Adenoma, Islet Cell; Pancreatic Neoplasms; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms; Carcinoma, Adenosquamous; Carcinoma, Neuroendocrine; Gastrointestinal Neoplasms	詳細
PMC-403	PMC-403	Phase 1 Clinical	Pharmabcine	Capillary Leak Syndrome; Solid tumours; Wet Macular Degeneration; Macular Degeneration	詳細
QBH-196	QBH-196	Phase 1 Clinical	Shenyang Pharmaceutical University	Solid tumours; Stomach Neoplasms	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Regorafenib	DAST; BAY-73-4506	Approved	Bayer AG	Stivarga, Resihance	United States	Colorectal Neoplasms	Bayer Healthcare Pharmaceuticals Inc	2012-09-27	Leukemia, Myeloid, Acute; Sarcoma, Ewing; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Bone Neoplasms; Peritoneal Neoplasms; Bile Duct Neoplasms; Esophageal adenocarcinoma; Lung Neoplasms; Thyroid Neoplasms; Fallopian Tube Neoplasms; Osteosarcoma; Thymoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Neoplasm Metastasis; Adenocarcinoma; Somatostatinoma; Gastrointestinal Neoplasms; Melanoma; Meningioma; Neoplasms; Solid tumours; Liver Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Insulinoma; Carcinoma, Islet Cell; Hemangiosarcoma; Rectal Neoplasms; Carcinoma, Renal Cell; Ovarian Neoplasms; Colonic Neoplasms; Carcinoma, Ovarian Epithelial; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Adenoma; Glucagonoma; Carcinoma, Adenoid Cystic; Gastrinoma; Sarcoma	詳細
Ripretinib	DCC-2618	Approved	Deciphera Pharmaceuticals	Qinlock, 擎乐	United States	Gastrointestinal Stromal Tumors	Deciphera Pharmaceuticals Llc	2020-05-15	Mastocytosis, Systemic; Neoplasms; Gastrointestinal Stromal Tumors	詳細
Ponatinib Hydrochloride	AP24534 hydrochloride; AP24534-HCL; AP24534 HCl; INCB-84344; AP-24534	Approved	Ariad	Iclusig	United States	Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic	Ariad Pharmaceuticals Inc	2012-12-14	Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Biphenotypic, Acute; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Lymphoma; Leukemia, Myeloid, Acute; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Chronic-Phase; Philadelphia Chromosome; Common Bile Duct Neoplasms; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Medullary thyroid cancer (MTC); Leukemia, Myelogenous, Chronic; Blast Crisis; Glioblastoma; Leukemia, Myelomonocytic, Chronic; Adenocarcinoma of Lung; Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Hematologic Neoplasms; Leukemia, Myeloid, Accelerated Phase; Leukemia; Head and Neck Neoplasms	詳細
Cabozantinib S-malate	XL-184; BMS-907351; RO7047650; RO-7047650	Approved	Exelixis Inc	Cometriq, Cabometyx	United States	Thyroid Neoplasms; Carcinoma, Neuroendocrine	Exelixis Inc	2012-11-29	Neuroblastoma; Thyroid Neoplasms; Hepatic Insufficiency; Astrocytoma; Peritoneal Neoplasms; Bile Duct Neoplasms; Colorectal Neoplasms; Gliosarcoma; Urethral Neoplasms; Sarcoma, Clear Cell; Uterine Neoplasms; Cholangiocarcinoma; Neurofibroma, Plexiform; Brain Neoplasms; Adenocarcinoma, Clear Cell; Carcinoma, Adenosquamous; Medullary thyroid cancer (MTC); Sarcoma, Ewing; Sarcoma; Osteosarcoma; Sarcoma, Alveolar Soft Part; Neoplasm Metastasis; Melanoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Endometrioid; Thyroid Cancer, Papillary; Meningioma; Paraganglioma; Neoplasms, Germ Cell and Embryonal; Carcinoma, Hepatocellular; Prostatic Neoplasms; Glioma; Brain metastases; Endometrial Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Squamous Cell; Lymphoma; Carcinoma, Neuroendocrine; Fallopian Tube Neoplasms; Carcinoma, Renal Cell; Adenoma, Islet Cell; Glioblastoma; Carcinoma, Ovarian Epithelial; Renal Insufficiency; Hepatoblastoma; Pheochromocytoma; Carcinoid Tumor; Carcinoma, Merkel Cell; Rejection of liver transp	詳細