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ADORA2A

ADORA2A Overview

English Name	Adenosine A2a receptor	Approved Drugs	53
Drugs in Clinical Trials	23	Target Synonym	Adenosine receptor A2a，ADORA2A，Adenosine A2a Receptor，ADORA2，Adenosine Receptor Subtype A2a，A2aR，RDC8，Receptor， Adenosine A2A
Highest Development Stage	Approved

English Name	Adenosine A2a receptor
Target Synonym	Adenosine receptor A2a，ADORA2A，Adenosine A2a Receptor，ADORA2，Adenosine Receptor Subtype A2a，A2aR，RDC8，Receptor， Adenosine A2A
Approved Drugs	53
Drugs in Clinical Trials	23
Highest Development Stage	Approved

ADORA2A Product List

Product Category
Protein (2)
Product Status
Launched (2)
Species
Human (2)
Tag
- (1)His Tag & Flag Tag (1)
Conjugate
Unconjugated (2)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
ADA-H52D3	Human	HEK293	Human ADORA2A Protein, Flag,His Tag (Detergent)
ADA-H52P4	Human	HEK293	Human ADORA2A Full Length Protein (VLP)

Total: 2

ADORA2A Background

Adenosine Receptor Subtype A2a (ADORA2A) is a G-protein coupled adenosine receptor encoded by the ADORA2A gene. It is mainly involved in pathophysiological processes including neuroinflammation, synaptic plasticity in glutamatergic synapses and neurogenesis.

ADORA2A Synonyms

ADORA2A,adenosine A2a receptor,A2aR, ADORA2, RDC8

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Naproxen/Caffeine	BAY-2880376	Phase 3 Clinical	Bayer AG	Pain, Postoperative	Details
Imaradenant	AZD-4635; HTL-1071	Phase 2 Clinical	Nxera Pharma UK Ltd	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours	Details
Ciforadenant	CPI-444; V-81444	Phase 2 Clinical	Vernalis (R&D) Ltd	Attention Deficit Disorder with Hyperactivity; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Multiple Myeloma; Neoplasms; Parkinson Disease	Details
Caffeinol		Phase 2 Clinical	Cardium Therapeutics	Alcoholic Intoxication; Alcoholism; Carcinoma, Non-Small-Cell Lung; Disruptive, Impulse Control, and Conduct Disorders; Ischemic Stroke	Details
Etrumadenant	AB-928; GS-0928	Phase 2 Clinical	Arcus Biosciences Inc	Breast Neoplasms; Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Head and Neck Neoplasms; Hormone-Resistant Prostate Neoplasms; Hypopharyngeal Neoplasms; Laryngeal Neoplasms; Lung Neoplasms; Melanoma; Mouth Neoplasms; Neoplasm Metastasis; Oral Squamous Cell Carcinoma; Oropharyngeal Neoplasms; Oropharyngeal Squamous Cell Carcinoma (OPSCC); Ovarian Neoplasms; Pharyngeal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms	Details
PORT-8	PORT-8; TT-53	Phase 2 Clinical	Tarus Therapeutics Inc	Solid tumours	Details
ND10(Theialife Inc)	ND-10; ND10	Phase 2 Clinical	Theialife Inc	Cataract; Dry Eye Syndromes; Myopia	Details
PORT-6	PORT-6; TT-10	Phase 2 Clinical	Impetis Biosciences Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Endometrial Neoplasms; Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Squamous Cell Carcinoma of Head and Neck	Details
MK-1088	MK-1088	Phase 2 Clinical	Merck Sharp & Dohme LLC	Solid tumours	Details
VG081821AC	VG081821AC; VG-081821AC	Phase 2 Clinical	Zhejiang Vimgreen Pharmaceuticals Ltd	Metabolic Dysfunction-Associated Steatotic Liver Disease; Parkinson Disease	Details
ILB-2109	WTS-001; ILB-2109	Phase 2 Clinical	Hangzhou Wutong Tree Pharmaceutical Co Ltd	Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Head and Neck Neoplasms; Hodgkin Disease; Melanoma; Nasopharyngeal Carcinoma; Neoplasms; Ovarian Neoplasms; Sarcoma; Solid tumours; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms	Details
PBF-999	PBF-999	Phase 1 Clinical	Palobiofarma Sl	Huntington Disease; Neoplasms	Details
[18F]MNI-444	[18F]MNI-444	Phase 1 Clinical	Invicro Llc	Diagnostic agents	Details
SHR-5126	SHR-5126	Phase 1 Clinical	Jiangsu Hengrui Medicine Co Ltd	Neoplasms	Details
Taminadenant	NIR-178; PBF-509	Phase 1 Clinical	Palobiofarma Sl	Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Colorectal Neoplasms; Head and Neck Neoplasms; Lymphoma, Large B-Cell, Diffuse; Melanoma; Ovarian Neoplasms; Pancreatic Neoplasms; Parkinson Disease; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Triple Negative Breast Neoplasms	Details
ST-4206	ST-4206	Phase 1 Clinical	Alfasigma Spa	Parkinson Disease	Details
CKD-512	CKD-512	Phase 1 Clinical	Chong Kun Dang Pharmaceutical Corp	Neoplasms; Solid tumours	Details
JNJ-86974680	JNJ-86974680	Phase 1 Clinical	Johnson & Johnson Enterprise Innovation Inc	Carcinoma, Non-Small-Cell Lung; Prostatic Neoplasms	Details
YZJ-5053	YZJ5053; YZJ-5053	Phase 1 Clinical	Shanghai Haiyan Pharmaceutical Technology Co Ltd	Neoplasm Metastasis; Solid tumours	Details
CT-1500	CT-1500	Phase 1 Clinical	Circadian Technologies Ltd		Details
DZD-2269	DZD-2269	Phase 1 Clinical	Dizal Pharmaceutical Co Ltd	Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant	Details
INCB-106385	INCB-106385	Phase 1 Clinical	Incyte Corp	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Gastrointestinal Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms	Details
CS-3005	CS-3005	Phase 1 Clinical	Cstone Pharmaceuticals (Suzhou) Co Ltd	Solid tumours	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Regadenoson Hydrate	CVT-3146	Approved	Astellas Pharma Inc	Rapiscan, 海诺生, Lexiscan	United States	Contrast agents	Astellas Pharma Inc	2008-04-10	Anemia, Sickle Cell; Astrocytoma; Cardiovascular contrast agents; Cardiovascular Diseases; Contrast agents; Coronary Artery Disease; Coronavirus Disease 2019 (COVID-19); Diagnostic agents; Glioblastoma; Glioma; Heart Diseases; Myocardial Ischemia; Oligodendroglioma; Pneumonia; Rejection of lung transplantation; Retinal Artery Occlusion	Details
Caffeine/Ergotamine Tartrate		Approved	Novartis Pharma Ag	Cafergot	Japan	Vascular Headaches; Migraine Disorders; Tension-Type Headache	Nichi-Iko Pharmaceutical Co Ltd	1948-11-26	Migraine Disorders; Tension-Type Headache; Vascular Headaches	Details
Oxtriphylline		Approved		Theocolin	Canada		null		Asthma	Details
Caffeine/Metamizole Sodium/Dihydroergotamine Mesylate		Approved		Cefaliv					Migraine Disorders	Details
Adenine		Approved		Leucon	Japan	Leukopenia	Ohara Pharmaceutical Co Ltd		Leukemia; Leukopenia	Details
Acetaminophen/Butalbital/Caffeine/Codeine Phosphate		Approved	Actavis Laboratories Ut Inc		United States	Headache; Headache Disorders	Actavis Laboratories Ut Inc	1992-07-30	Headache; Headache Disorders	Details
Istradefylline	KW-6002	Approved	Kyowa Hakko Kirin Co Ltd	Nourianz, Nouriast	Japan	Parkinson Disease	Kyowa Hakko Kirin Co Ltd	2013-03-25	Amyotrophic Lateral Sclerosis; Cognition Disorders; Hepatic Insufficiency; Movement Disorders; Parkinson Disease; Restless Legs Syndrome; Sleep Wake Disorders; Substance-Related Disorders	Details
Sodium Citrate/Citric Acid/Dextrose/Monosodium phosphate/Adenine/Mannitol/Sodium Chloride		Approved								Details
Sodium Citrate/Citric Acid/Dextrose		Approved								Details
Sodium Citrate/Citric Acid/Dextrose/Monosodium phosphate/Adenine		Approved								Details
Aspirin/Acetaminophen/Caffeine/Thiamine		Approved							Fever; Pain	Details
Propranolol hydrochloride/Caffeine/Phenytoin Sodium		Approved			Mainland China		Hebei Tiancheng Pharmaceutical Co Ltd			Details
Salicylamide/Acetaminophen/Caffeine		Approved							Arthralgia; Fever; Headache; Neuralgia; Rheumatic Diseases	Details
Compound Paracetamol Caffeine and Pseudoephedrine Hydrochloride		Approved							Common Cold	Details
Acetaminophen/Methylephedrine Hydrochloride/Dextromethorphan Hydrobromide/Chlorphenamine Maleate/Caffeine/Sulfogaiacol		Approved			Mainland China	Common Cold	Zhejiang Apeloa Kangyu Pharmaceutical Co Ltd		Common Cold	Details
Dextromethorphan Hydrobromide/Chlorphenamine Maleate/Sodium Citrate/Ammonium Chloride/Caffeine		Approved		尔可芬					Cough	Details
Acetaminophen/Caffeine/Codeine Phosphate/Diphenhydramine Hydrochloride		Approved		斯力帮					Headache	Details
Ferric Ammonium Citrate/Vitamin B1/Sodium glycerophosphate/Caffeine		Approved							Ischemia	Details
Norethidranum Dipropionas/Caffeine/Vitamin B6		Approved			Mainland China	Contraception	Huazhong Pharmaceutical Co Ltd	1981-01-01	Contraception	Details
Acetaminophen/Propyphenazone/Caffeine		Approved		散利痛, 散列通					Common Cold	Details
Quinine Hydrochloride Hydrate/Caffeine		Approved							Malaria	Details
Dihydroergocryptine/Caffeine		Approved		洛斯宝, VASOBRAL					Diabetes Mellitus; Diabetic Retinopathy	Details
Aminophenazone/Phenacetin/Caffeine		Approved							Fever; Pain	Details
Aminophenazone/Caffeine/Calcium Glycerophosphate		Approved							Dysmenorrhea; Headache; Neuralgia	Details
Acetaminophen/Caffeine/Chlorphenamine Maleate		Approved							Common Cold	Details
Aminophenazone/Caffeine/Chlorphenamine Maleate		Approved							Common Cold; Headache; Neuralgia	Details
Aspirin/Caffeine/Codeine Phosphate		Approved		柯克					Pain	Details
Acetaminophen/Pseudoephedrine Hydrochloride/Caffeine		Approved							Common Cold	Details
Aspirin/Acetaminophen/Caffeine/Chlorphenamine Maleate		Approved							Common Cold	Details
Aspirin/Caffeine/Chlorphenamine Maleate/Tartaric Acid		Approved							Common Cold	Details
Acetaminophen/Caffeine/Pseudoephedrine Hydrochloride/Chlorphenamine Maleate		Approved							Common Cold	Details
Aminophenazone/Phenacetin/Caffeine/Phenobarbital		Approved							Migraine Disorders	Details
Acetaminophen/Chlorphenamine Maleate/Caffeine/Guaifenesin		Approved							Common Cold	Details
Acetaminophen/Amantadine Hydrochloride/Caffeine/Artificial Bezoar		Approved							Common Cold	Details
Acetaminophen/Salicylamide/Pseudoephedrine Hydrochloride/Caffeine/Triprolidine Hydrochloride Hydrate		Approved		联邦菲迪乐					Common Cold	Details
Sodium Benzoate/Caffeine		Approved							Central Nervous System Diseases	Details
Aminophenazone/Caffeine		Approved							Fever	Details
Antipyrine/Caffeine		Approved							Common Cold	Details
Aspirin/Caffeine		Approved							Common Cold	Details
Antipyrine/Caffeine/Citric Acid		Approved		米格来宁	Mainland China	Sedation	Mudanjiang Lingtai Medicdment Co Ltd, Xi'An Disai Biological Pharmaceutical Co Ltd, Heilongjiang Hasing Pharmaceutical Group Co Ltd, Huadong Medicine (Xi'An) Bodyguard Pharmaceutical Co Ltd	1982-01-01	Sedation	Details
Aminophenazone/Acetaminophen/Caffeine/Chlorphenamine Maleate		Approved		克感敏, 扑感敏, 朴感敏					Common Cold	Details
Acetaminophen/Caffeine/Ephedrine Hydrochloride/Diphenhydramine Hydrochloride		Approved							Influenza, Human	Details
Acetaminophen/Caffeine/Chlorphenamine Maleate/Artificial Bezoar		Approved							Common Cold	Details
Aspirin/Phenacetin/Caffeine		Approved							Arthralgia; Dysmenorrhea; Fever; Headache; Neuralgia; Toothache	Details
Aspirin/Caffeine/Acetaminophen		Approved			United States	Migraine Disorders	Haleon PLC		Anesthesia; Migraine Disorders	Details
Acetaminophen/Butalbital/Caffeine		Approved							Headache	Details
Acetaminophen/Caffeine		Approved	Zentiva As		Mainland China	Pain	Sino--American Shanghai Squibb Pharmaceutical Ltd		Pain	Details
Sodium glycerophosphate/Caffeine/Vitamin B/Phosphoric Acid/Niacin		Approved								Details
Acetaminophen/Caffeine/Phenylephrine Hydrochloride/Chlorphenamine Maleate/Vitamin B		Approved								Details
Acetaminophen/Chlorphenamine Maleate/Methylephedrine Hydrochloride/Sulfogaiacol/Caffeine		Approved			Mainland China	Common Cold	Hainan Sanfengyou Pharmaceutical Co Ltd	2006-05-16	Common Cold	Details
Brompheniramine Maleate/Bromhexine Hydrochloride/Caffeine/Acetaminophen/Phenylephrine Hydrochloride		Approved							Common Cold	Details
Acetaminophen/Amantadine Hydrochloride/Caffeine/Chlorphenamine Maleate/Artificial Bezoar		Approved		复方氨酚烷胺	Mainland China	Common Cold	null	1984-01-01	Common Cold	Details
Caffeine		Approved							Apnea; Cocaine-Related Disorders; Cognitive Dysfunction; Consciousness; Delirium; Diabetes Complications; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disorders of Excessive Somnolence; Fatigue; Fetal Membranes, Premature Rupture; Intermittent Claudication; Memory Disorders; Mental Fatigue; Parkinson Disease; Postoperative Cognitive Complications; Sexual Dysfunction, Physiological; Sleepiness; Spinal Cord Injuries	Details