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Alpha-Synuclein

Alpha-Synuclein 詳細

英語名	Synuclein alpha	市販薬剤の数	0
治験薬の数	25	ターゲットの別称	Truncated Alpha Synuclein，Α-Synuclein，PARK1，SNCA，Synuclein Alpha，Synuclein， Alpha (Non A4 Component Of Amyloid Precursor)，NACP，Parkinson Disease (Autosomal Dominant， Lewy Body) 4，Non-A4 Component Of Amyloid Precursor，Non A4 Component Of Amyloid Precursor，Non A-Beta Component Of AD Amyloid，Non-A Beta Component Of AD Amyloid，Synuclein Alpha-140，I+/--Synuclein，Î±-Synuclein，PARK4，alpha-Synuclein
研究＆開発段階	Phase 3 Clinical

英語名	Synuclein alpha
ターゲットの別称	Truncated Alpha Synuclein，Α-Synuclein，PARK1，SNCA，Synuclein Alpha，Synuclein， Alpha (Non A4 Component Of Amyloid Precursor)，NACP，Parkinson Disease (Autosomal Dominant， Lewy Body) 4，Non-A4 Component Of Amyloid Precursor，Non A4 Component Of Amyloid Precursor，Non A-Beta Component Of AD Amyloid，Non-A Beta Component Of AD Amyloid，Synuclein Alpha-140，I+/--Synuclein，Î±-Synuclein，PARK4，alpha-Synuclein
市販薬剤の数	0
治験薬の数	25
研究＆開発段階	Phase 3 Clinical

Alpha-Synuclein 製品リスト

属性
Protein (17)Cell (1)
製品ライブラリ
オンライン (18)
種
Human (15)Cynomolgus (1)Mouse (2)
タグ
His Tag (8)His Tag & Avi Tag (1)Fc Tag (1)Tag Free (7)GFP Tag (1)
マーカー
Unconjugated (12)Biotin-labeled (1)- (1)AF488 Labeled (2)AF647 Labeled (2)

製品番号	種	発現システム	製品説明
HOT ALN-H5114	Human	E. coli	Human Alpha-Synuclein (A53T) Pre-formed Fibrils Protein, Tag Free
HOT ALN-H5115	Human	E. coli	Human Alpha-Synuclein Pre-formed Fibrils Protein, Tag Free
HOT ALN-H5214	Human	E. coli	Human Alpha-Synuclein Protein, Tag Free, low endotoxin (MALS verified)
HOT ALN-H5253	Human	HEK293	Human Alpha-Synuclein Protein, Fc Tag (MALS verified)
HOT ALN-H52H8	Human	E. coli	Human Alpha-Synuclein Protein, His Tag
HOT ALN-H82H8	Human	E. coli	Biotinylated Human Alpha-Synuclein Protein, His,Avitag™
HOT CHEK-ATP085	Human	HEK293	HEK293/Human Alpha-synuclein (GFP) Stable Cell Line
ALN-H5116	Human	E. coli	Human Alpha-Synuclein (A53T) Protein, Tag Free, low endotoxin (MALS verified)
ALN-H5117	Human	E. coli	Human Alpha-Synuclein (E46K) Protein, Tag Free
ALN-H51H4	Human	E. coli	Human Alpha-Synuclein Pre-formed Fibrils Protein, His Tag

総数量18

Alpha-Synucleinバックグランド

Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

Alpha-Synuclein分子の別称

SNCA,NACP,PARK1,alpha-Synuclein

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Buntanetap	ANVS-405; ANVS-401	Phase 3 Clinical	Raptor Pharmaceutical	Alzheimer Disease; Chronic Traumatic Encephalopathy; Cognitive Dysfunction; Down Syndrome; Frontotemporal Dementia; Parkinson Disease	詳細
Amlenetug	Lu AF-82422; Lu AF82422; Lu-AF82422	Phase 3 Clinical	Genmab A/S, H. Lundbeck A/S	Multiple System Atrophy; Parkinson Disease	詳細
Prasinezumab	PRX-002; RG-7935; NEOD-002; RO-7046015	Phase 3 Clinical	Prothena	Parkinson Disease	詳細
Kenterin	ENT-01; kenterin; Enterin-01	Phase 2 Clinical	Enterin Inc	Constipation; Dementia; Parkinson Disease	詳細
PBT-434	PBT-434; ATH-434	Phase 2 Clinical	Prana Biotechnology Ltd	Multiple System Atrophy	詳細
MT101-5	MT101-5	Phase 2 Clinical	Mthera Pharma Co Ltd	Parkinson Disease	詳細
AMDX-2011P	AMDX2011P; AMDX-2011P	Phase 2 Clinical	Amydis Inc	Alzheimer Disease; Amyotrophic Lateral Sclerosis; Cerebral Amyloid Angiopathy; Glaucoma, Open-Angle; Parkinson Disease	詳細
ACI-7104	ACI-7104.056; ACI-7104	Phase 2 Clinical	Ac Immune Sa	Parkinson Disease	詳細
Minzasolmin	UCB-1332; NPT200-11; DLX-313; DLX313; UCB-0599	Phase 2 Clinical	Neuropore Therapies Inc	Parkinson Disease	詳細
Exidavnemab	PD-0805; BAN-0805; BBV-0805; ABBV-0805; PR-1808164	Phase 2 Clinical	Bioarctic Ab	Multiple System Atrophy; Parkinson Disease	詳細
Emrusolmin	TEV-56286; TEV-'286; Anle-138b; TEV-286	Phase 2 Clinical	Ludwig-Maximilians-University, Max Planck Institute for Biophysical Chemistry	Multiple System Atrophy; Parkinson Disease	詳細
ION-464	BIIB-101; IONIS-BIIB6 Rx; ION-464	Phase 1 Clinical	Ionis Pharmaceuticals Inc	Multiple System Atrophy	詳細
UB-312	UB-312	Phase 1 Clinical	United Neuroscience Ltd	Multiple System Atrophy; Parkinson Disease; Parkinsonian Disorders	詳細
SAR-446159	SAR-446159; ABL-301	Phase 1 Clinical	Abl Bio Inc	Parkinson Disease	詳細
SST-001	SST001; SST-001; 18F-FD4	Phase 1 Clinical	SynuSight Biotech (Shanghai) Co Ltd	Diagnostic agents; Lewy Body Disease; Multiple System Atrophy; Parkinson Disease; Synucleinopathies	詳細
18F-CP6A	18F-CP6A	Phase 1 Clinical	Shenzhen Braegen Pharmaceutical Co Ltd	Synucleinopathies	詳細
AB-16	AB-16	Phase 1 Clinical	Autotac Bio Inc	Parkinson Disease	詳細
ACI-12589	ACI-12589; a-syn-PET tracer (AC Immune); [18F]MNI-1216; [18F]ACI-12589	Phase 1 Clinical	Ac Immune Sa, Biogen Inc, Invicro Llc	Lewy Body Disease; Multiple System Atrophy; Parkinson Disease; Synucleinopathies	詳細
PK-081	PK081; PK-081	Phase 1 Clinical	PharmaKure Ltd	Parkinson Disease	詳細
[11C]SY-08	[11C]SY-08; [11C]SY08	Phase 1 Clinical	Massachusetts General Hospital	Lewy Body Disease; Multiple System Atrophy; Parkinson Disease	詳細
SNP201	SNP201; SNP-201	Phase 1 Clinical	SciNeuro Pharmaceuticals	Parkinson Disease	詳細
[18F]UCB-2897	UCB-2897; [18F]UCB-2897	Phase 1 Clinical	Invicro Llc	Multiple System Atrophy; Parkinson Disease	詳細
ACI-3847	ACI-3847; 18F-ACI-3847	Phase 1 Clinical	Ac Immune Sa, Biogen Inc	Neurodegenerative Diseases; Parkinson Disease	詳細
UCB-7853	UCB-7853	Phase 1 Clinical	Ucb Biopharma Srl	Parkinson Disease	詳細
Syneuro (Indus Biotech)		Clinical	Indus Biotech Pvt Ltd	Parkinson Disease	詳細