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Apo-A1

Apo-A1 Overview

English Name	Apolipoprotein A-I	Approved Drugs	0
Drugs in Clinical Trials	3	Target Synonym	Epididymis Secretory Sperm Binding Protein，Apolipoprotein A-I(1-242)，APOA1，ProapoA-I，Apo-AI，Apolipoprotein A1，Apo(A)，ApoA-I，Apolipoprotein A-I，HPALP2
Highest Development Stage	Phase 2 Clinical

English Name	Apolipoprotein A-I
Target Synonym	Epididymis Secretory Sperm Binding Protein，Apolipoprotein A-I(1-242)，APOA1，ProapoA-I，Apo-AI，Apolipoprotein A1，Apo(A)，ApoA-I，Apolipoprotein A-I，HPALP2
Approved Drugs	0
Drugs in Clinical Trials	3
Highest Development Stage	Phase 2 Clinical

Apo-A1 Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
AP1-H5225	Human	HEK293	Human Apo-A1 Protein, His Tag

Total: 1

Apo-A1 Background

ApoA1 is also known as apolipoprotein A-I, ApoA-I , and is the major protein component of high density lipoprotein (HDL) in plasma. It has a specific role in lipid metabolism. Chylomicrons secreted from the intestinal enterocyte also contain ApoA1 but it is quickly transferred to HDL in the bloodstream. The protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterol acyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. ApoA-I was also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. In addition, it has been shown that ApoA1 is implicated in the anti-endotoxin function of HDL via interaction with lipopolysaccharide or endotoxin.

Apo-A1 Synonyms

Apolipoprotein A-I,APOA1,MGC117399

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Zerlasiran	SLN-360	Phase 2 Clinical	Silence Therapeutics Plc	Atherosclerosis; Cardiovascular Diseases; Dyslipidemias; Hyperlipidemias; Lipid Metabolism Disorders	Details
Fx-5A	Fx-5A	Phase 1 Clinical	Kinemed Inc	Cardiovascular Diseases	Details
Recombinant NV-A01 adenovirus		Phase 1 Clinical	Nanjing Nuowei Biotechnology Co Ltd	Glioblastoma; Solid tumours	Details