言語を選択
新規登録

Axl

Axl 詳細

英語名AXL receptor tyrosine kinase市販薬剤の数2
治験薬の数27ターゲットの別称EC:2.7.10.1，EC 2.7.10，UFO，AXL Transforming Sequence/Gene，AXL Oncogene，EC 2.7.10.1，JTK11，Tyro7，ARK，Tyrosine-protein kinase receptor UFO，AXL，AXL Receptor Tyrosine Kinase
研究＆開発段階Approved
英語名AXL receptor tyrosine kinase
ターゲットの別称EC:2.7.10.1，EC 2.7.10，UFO，AXL Transforming Sequence/Gene，AXL Oncogene，EC 2.7.10.1，JTK11，Tyro7，ARK，Tyrosine-protein kinase receptor UFO，AXL，AXL Receptor Tyrosine Kinase
市販薬剤の数2
治験薬の数27
研究＆開発段階Approved

Axl 製品リスト

  • 属性

    Protein (4)

  • 製品ライブラリ

    オンライン (4)

  • 種

    Human (3)Cynomolgus (1)

  • タグ

    His Tag (2)Fc Tag (1)Fc Tag & Avi Tag (1)

  • マーカー

    Unconjugated (3)Biotin-labeled (1)

製品番号種発現システム製品説明タンパク質の構造純度特性
HOT
AXL-H82F9
Human
HEK293
Biotinylated Human AXL Protein, Fc,Avitag™ (MALS verified)
AXL-H5226
Human
HEK293
Human Axl Protein, His Tag (SPR verified)
AXL-H5253
Human
HEK293
Human Axl Protein, Fc Tag (MALS verified)
AXL-C52H3
Cynomolgus
HEK293
Cynomolgus Axl Protein, His Tag (SPR verified)
総数量4
  • 1

Axlバックグランド

AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.

Axl分子の別称

AXL,UFO

ライセンシング

プロジェクト薬物タイプ治療分野適応症ステージエリア
AXL inhibitorSmall moleculeOncology/CancerSTK11_mut NSCLC,other cancersPhase IGlobal

治験薬に関する情報

英語名研究コード研究開発ステージ会社適応症臨床試験
BatiraxceptS6-500c; 3D-229; 3D229; 3D-299; Ruga-S6; AB-007; AVB 500; AVB-500; Aravive S-6; AVB-S6-500Phase 3 ClinicalAravive IncCarcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Fallopian Tube Neoplasms; Glomerulonephritis, IGA; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Solid tumours; Uterine Neoplasms
詳細
KC1036KC1036; KC-1036Phase 3 ClinicalBeijing Konruns Pharmaceutical Co LtdAdenocarcinoma; Digestive System Neoplasms; Esophageal Squamous Cell Carcinoma; Hematologic Neoplasms; Neoplasm Metastasis; Sarcoma, Ewing; Solid tumours; Thymus Neoplasms
詳細
SitravatinibMG-516; MG-91516; MGCD-516; IND-155305; MGCD-0516Phase 3 ClinicalMirati Therapeutics IncBiliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Endometrial Neoplasms; Esophageal Squamous Cell Carcinoma; Gastrointestinal Neoplasms; Hepatic Insufficiency; Kidney Neoplasms; Liposarcoma; Lung Diseases; Lung Neoplasms; Metastatic breast cancer; Neoplasms; Oral Squamous Cell Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Ureteral Neoplasms; Uterine Cervical Neoplasms; Uveal melanoma
詳細
ButylidenephthalideNSC-325307; LF-001 (Everfront Biotech); EF-001; HK-001; BDPHPhase 3 ClinicalEverfront Biotech Co LtdAmyotrophic Lateral Sclerosis; Glioblastoma; Glioma
詳細
Ningetinib TosylateCT-053-PTSA; CT-053Phase 2 ClinicalHec Pharm Co LtdCarcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Intestinal Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Solid tumours; Stomach Neoplasms
詳細
Mecbotamab vedotinBA-3011; BA3011; BA 3011Phase 2 ClinicalBioatlaCarcinoma, Non-Small-Cell Lung; Dermatofibrosarcoma; Ovarian Neoplasms; Sarcoma
詳細
Merestinib5OGS5K699E; LY-2801653Phase 2 ClinicalEli Lilly And CompanyBiliary Tract Neoplasms; Bone metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Colorectal Neoplasms; Gallbladder Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microsatellite instability-high cancer; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Skin Melanoma; Solid tumours
詳細
TamnorzatinibONO-7475Phase 2 ClinicalOno Pharmaceutical Co LtdCarcinoma, Non-Small-Cell Lung; Leukemia; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Pancreatic Neoplasms; Solid tumours
詳細
BemcentinibBGB-324; R-428; BGB-3234Phase 2 ClinicalRigel Pharmaceuticals IncAdenocarcinoma of Lung; Carcinoma, Non-Small-Cell Lung; CNS Embryonal Tumor; Coronavirus Disease 2019 (COVID-19); Glioblastoma; Inflammatory Breast Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Melanoma; Mesothelioma; Myelodysplastic Syndromes; Pancreatic Neoplasms; Triple Negative Breast Neoplasms
詳細
Enapotamab vedotinAXL-107-MMAEPhase 2 ClinicalGenmab A/S, Seagen IncCarcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Melanoma; Ovarian Neoplasms; Sarcoma; Solid tumours; Thyroid Neoplasms; Uterine Cervical Neoplasms
詳細
CD73/AXL.HypoSti.CAR-T cells therapy (Pla General Hospital)Phase 2 ClinicalPla General HospitalSolid tumours
詳細
FC-084-CSAFC084CSA; FC-084-CSAPhase 2 ClinicalFindCure Biosciences (ZhongShan) Co LtdSolid tumours
詳細
AdrixetinibQ-702Phase 2 ClinicalLead Discovery Center GmbH, Max Planck Institute of Biochemistry, Vichem ChemieBlastic Plasmacytoid Dendritic Cell Neoplasm; Carcinoma, Hepatocellular; Central Nervous System Lymphoma; Erdheim-Chester Disease; Esophageal Neoplasms; Graft vs Host Disease; Hematologic Neoplasms; Histiocytic Sarcoma; Histiocytosis, Langerhans-Cell; Histiocytosis, Sinus; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Follicular; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Myelodysplastic Syndromes; Neoplasm Metastasis; Neoplasms; Neoplasms, Plasma Cell; Solid tumours; Stomach Neoplasms; Uterine Cervical Neoplasms; Waldenstrom Macroglobulinemia
詳細
DubermatinibTP-0903Phase 1 ClinicalSumitomo DainipponCarcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Melanoma; Ovarian Neoplasms; Solid tumours
詳細
INCB-081776INCB-81776; INCB-081776Phase 1 ClinicalIncyte CorpSolid tumours; Squamous Cell Carcinoma of Head and Neck
詳細
BPI-9016BPI-9016; BPI-9016MPhase 1 ClinicalBetta Pharmaceuticals Co LtdCarcinoma, Non-Small-Cell Lung; Solid tumours
詳細
A-416A416; A-416Phase 1 ClinicalKlus Pharma IncSolid tumours
詳細
NTQ-2494NTQ2494; NTQ-2494Phase 1 ClinicalNanjing Zhengda Tianqing Pharmaceutical Co LtdHematologic Neoplasms; Leukemia, Myeloid, Acute; Solid tumours
詳細
CTS-2016CTS-2016Phase 1 ClinicalCytosinLab Therapeutics Co LtdLeukemia, Myeloid, Acute; Myelodysplastic Syndromes
詳細
LigritinibAB-801Phase 1 ClinicalArcus Biosciences IncNeoplasms
詳細
XZB-0004XZB-0004; SLC-0211; SLC-391Phase 1 ClinicalXuanzhu (Shijiazhuang) Biotechnology Co LtdCarcinoma, Non-Small-Cell Lung; Foodborne Diseases; Hematologic Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Myelodysplastic Syndromes; Solid tumours
詳細
NP-107NP107; NP-107Phase 1 ClinicalShanghai Nawei Biotechnology Co LtdSolid tumours
詳細
TT-00973TT-00973Phase 1 ClinicalTransThera Sciences (Nanjing) IncSolid tumours
詳細
AGX-0073AGX-0073Phase 1 ClinicalShanghai Aojian Biological Technology Co LtdSolid tumours
詳細
Denfivontinib HydrochlorideSKI-G-801; G-801; G-749 HydrochloridePhase 1 ClinicalGenoscoLeukemia, Myeloid, Acute; Solid tumours
詳細
NP-01 (Shijiazhuang No.4 Pharmaceutical/Nanjing Nadingfei Medical Technology)NP-01Phase 1 ClinicalNanjing Nadingfei Pharmaceutical Technology Co Ltd, Shijiazhuang No 4 Pharmaceutical Co LtdLiver Neoplasms; Lung Neoplasms; Solid tumours; Stomach Neoplasms
詳細
NPS-1034HOPE-777; KDDF-201111-02Neopharma Ltd
詳細

市販薬剤に関する情報

英語名研究コード研究開発ステージ会社オリジナル製品名最初に承認をした国最初の適応症最初に承認を受けた会社承認された日付適応症臨床試験
Gilteritinib FumarateASP-2215 hemifumarate; ASP-2215; 66D-92MGC8M (UNII code)ApprovedAstellas Pharma IncXospataJapanLeukemia, Myeloid, AcuteAstellas Pharma Inc2018-09-21Carcinoma, Non-Small-Cell Lung; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Lung Neoplasms; Renal Insufficiency; Solid tumours
詳細
Cabozantinib S-malateXL-184; BMS-907351; RO7047650; RO-7047650ApprovedExelixis IncCometriq, CabometyxUnited StatesThyroid Neoplasms; Carcinoma, NeuroendocrineExelixis Inc2012-11-29Adenocarcinoma, Clear Cell; Adenocarcinoma, Follicular; Adenoma, Islet Cell; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Astrocytoma; Bile Duct Neoplasms; Bone metastases; Brain metastases; Brain Neoplasms; Breast Neoplasms; Carcinoma, Adenosquamous; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Glioblastoma; Glioma; Gliosarcoma; Hepatic Insufficiency; Hepatoblastoma; HIV Infections; Kidney Neoplasms; Leiomyosarcoma; Leukemia, Myeloid, Acute; Lymphoma; Medullary thyroid cancer (MTC); Melanoma; Meningioma; Multiple Myeloma; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroendocrin
詳細
  • 詳細
  • 製品リスト
  • 市販薬剤に関する情報
  • 治験薬に関する情報
共有：

採用情報法的規制サイトマッププライバシーポリシー利用規約
ウェブサイトに関するフィードバック
お問い合わせ

お問い合わせ
グローバル：+1 800-810-0816(Toll Free)

メールアドレス
order.jp@acrobiosystems.com

アクロバイオシステムズ株式会社
〒101-0051
東京都千代田区神田神保町1-32-8