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B7-2

B7-2 詳細

英語名	Cluster of differentiation 86	市販薬剤の数	2
治験薬の数	7	ターゲットの別称	FUN-1，CTLA-4 counter-receptor B7.2，CD28LG2，Activation B7-2 antigen，CD86，CD86 Molecule，CD86 Antigen (CD28 Antigen Ligand 2， B7-2 Antigen)，BU63，B70，B-Lymphocyte Activation Antigen B7-2，T-Lymphocyte Activation Antigen CD86，B-Lymphocyte Antigen B7-2，CD86 Antigen，LAB72，B7-2，B7.2，B7-2 Antigen
研究＆開発段階	Approved

英語名	Cluster of differentiation 86
ターゲットの別称	FUN-1，CTLA-4 counter-receptor B7.2，CD28LG2，Activation B7-2 antigen，CD86，CD86 Molecule，CD86 Antigen (CD28 Antigen Ligand 2， B7-2 Antigen)，BU63，B70，B-Lymphocyte Activation Antigen B7-2，T-Lymphocyte Activation Antigen CD86，B-Lymphocyte Antigen B7-2，CD86 Antigen，LAB72，B7-2，B7.2，B7-2 Antigen
市販薬剤の数	2
治験薬の数	7
研究＆開発段階	Approved

B7-2 製品リスト

属性
Protein (8)
製品ライブラリ
オンライン (8)
種
Human (3)Cynomolgus / Rhesus macaque (2)Mouse (2)Rat (1)
タグ
Fc Tag (3)His Tag (4)Fc Tag & Avi Tag (1)
マーカー
Unconjugated (7)Biotin-labeled (1)

製品番号	種	発現システム	製品説明
HOT CD6-H5223	Human	HEK293	Human B7-2 / CD86 Protein, His Tag (MALS verified)
HOT CD6-H5257	Human	HEK293	Human B7-2 / CD86 Protein, Fc Tag, premium grade
HOT CD6-H82F5	Human	HEK293	Biotinylated Human B7-2 / CD86 Protein, Fc,Avitag™, premium grade
CD6-M5251	Mouse	HEK293	Mouse B7-2 / CD86 Protein, Fc Tag (MALS verified)
CD6-M52H0	Mouse	HEK293	Mouse B7-2 / CD86 Protein, His Tag (MALS verified)
CD6-C5254	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus / Rhesus macaque B7-2 / CD86 Protein, Fc Tag
CD6-C52H5	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus / Rhesus macaque B7-2 / CD86 Protein, His Tag (MALS verified)
CD6-R52H9	Rat	HEK293	Rat B7-2 / CD86 Protein, His Tag

総数量8

B7-2バックグランド

Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon γ. CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. Recent study has revealed that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival. Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-κB-signaling pathway in macrophages. CD86 thus is regarded as a promising candidate for immune therapy. CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.

B7-2分子の別称

CD86,B7-2,B70,CD28LG2,LAB72,MGC34413

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
ORCA-010	ORCA-010	Phase 2 Clinical	Orca Therapeutics Bv	Prostatic Neoplasms	詳細
Chimeric antigen receptor T-cell therapy (Hunan Zhaotai Yongren Biotech)	Z-CTLs	Phase 1 Clinical	Hunan Zhaotai Yongren Biotech Co Ltd	Carcinoma, Non-Small-Cell Lung	詳細
AN-8025	AN-8025	Phase 1 Clinical	Hangzhou Adlai Nortye Biopharma Co Ltd	Solid tumours	詳細
M-5542	M5542; M-5542	Phase 1 Clinical	Merck & Co Inc		詳細
Abatacept biosimilar (Kashiv BioSciences)	KSHB-002; KSHB002	Phase 1 Clinical	Kashiv BioSciences LLC	Arthritis, Rheumatoid; Immune System Diseases	詳細
Abatacept biosimilar (Dr. Reddy's Laboratories)	DRL-AB	Phase 1 Clinical	Dr.Reddy's Laboratories Ltd	Arthritis, Rheumatoid	詳細
Recombinant human CTLA-4-FC fusion protein(Beijing Vdjbio)	VDJ002; VDJ-002	Phase 1 Clinical	Beijing Vdjbio Co Ltd	Arthritis, Rheumatoid; Lupus Erythematosus, Systemic	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Belatacept	LEA29Y; LEA-029; BMS-224818; L104EA29YIg	Approved	Bristol-Myers Squibb Company	Nulojix	United States	Rejection of renal transplantation	Bristol-Myers Squibb Company	2011-06-15	Arthritis, Rheumatoid; Delayed Graft Function; Diabetes Mellitus, Type 1; Graft Rejection; Kidney Failure, Chronic; Pancreatic neuroendocrine tumors (pNET); Proteinuria; Rejection in heart transplantation; Rejection of renal transplantation; Rejection of organ transplantation	詳細
Abatacept	BMS-188667; ONO-4164; ONO-4164SC; BMS-188667SC	Approved	Bristol-Myers Squibb Company	Orencia, 恩瑞舒	United States	Arthritis, Rheumatoid	Bristol-Myers Squibb Company	2005-12-23	Allergic asthma; Alopecia Areata; Anemia, Aplastic; Anemia, Diamond-Blackfan; Anemia, Sickle Cell; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Arthralgia; Arthritis; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Behcet Syndrome; beta-Thalassemia; Cardiovascular Diseases; Chediak-Higashi Syndrome; Colitis, Ulcerative; Common Variable Immunodeficiency; Coronavirus Disease 2019 (COVID-19); Crohn Disease; Dermatomyositis; Diabetes Mellitus, Type 1; Dyskeratosis Congenita; Eye Diseases; Fanconi Anemia; Giant Cell Arteritis; Glomerulosclerosis, Focal Segmental; Graft vs Host Disease; Granulomatosis with Polyangiitis; Granulomatous Disease, Chronic; Healthy Aging; Hematologic Diseases; Hematologic Neoplasms; Immunoglobulin G4-Related Disease; Inflammation; Kostmann Syndrome; Leukocyte-Adhesion Deficiency Syndrome; Lung Diseases, Interstitial; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphohistiocytosis, Hemophagocytic; Mucopolysaccharidosis I; Multiple Sclerosis; Multiple S	詳細

レビュー

1***22019-09-26
0評価
Human B7-2 / CD86 Protein, Fc Tag, premium grade
SEC showed a high purity of the protein, which can reach to higher than 90%. Functional bioactivity is also very good. It can bind with PD-L1 in vitro. If it is used to measure affinity, the signal will be higher if pdl1 concentration is increased.