BMPR-1A

BMPR-1A

BMPR-1A 詳細

Molecule Name
Bone morphogenetic protein receptor type-1A
分子の別称
BMPR-1A,ALK-3,ACVRLK3,CD292,SKR5
Drug Development Progress
治験薬の数2
市販薬剤の数2
研究&開発段階Approved
ターゲットの別称
Bone Morphogenetic Protein Receptor Type 1A,EC 2.7.11,Activin receptor-like kinase 3,Bone morphogenetic protein receptor type-1A,ALK3,BMPR1A,Bone Morphogenetic Protein Receptor, Type IA,Serine/Threonine-Protein Kinase Receptor R5,ACVRLK3,BMPR-1A,SKR5,Activin A Receptor, Type II-Like Kinase 3,CD292 Antigen,EC 2.7.11.30,10q23del,CD292,BMP type-1A receptor,ALK-3,EC:2.7.11.30
バックグランド
The bone morphogenetic protein receptor, type IA is also known as BMPR1A or ALK3 is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 290). The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis.

BMPR-1A 製品リスト

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治験薬に関する情報

英語名研究コード研究開発ステージ会社適応症臨床試験
Recombinant Human Bone Morphogenetic Protein-2(University Of Baghdad)Phase 1 ClinicalUniversity Of Baghdad
Diabetes Mellitus; Hematologic Diseases; Hypertension
詳細
Recombinant human bone morphogenetic protein 4 (Stemgen)HS-214; hrBMP4Phase 1 ClinicalStemgen
Asthma; Bronchiolitis Obliterans; Glioblastoma; Lung Diseases; Rejection of lung transplantation
詳細

市販薬剤に関する情報

英語名研究コード研究開発ステージ会社オリジナル製品名最初に承認をした国最初の適応症最初に承認を受けた会社承認された日付適応症臨床試験
Dibotermin alfaYM-484; rhBMP-2/CPMApprovedMedtronicInductosEUTibial FracturesMedtronic Biopharma Bv2002-09-09
Fractures, Bone; Osteoarthritis; Osteoarthritis, Spine; Radius Fractures; Tibial Fractures; Tooth Injuries
詳細
DWP-431DWP-431; rhBMP-2ApprovedDaewoong Pharmaceutical Co LtdNovosis, Novosis-DentalSouth KoreaAlveolar Bone LossDaewoong Pharmaceutical Co Ltd2013-01-01
Alveolar Bone Loss; Intervertebral Disc Degeneration
詳細