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Cadherin-6

Cadherin-6 詳細

英語名	Cadherin-6	市販薬剤の数	0
治験薬の数	5	ターゲットの別称	Kidney cadherin，K-cadherin，Cadherin 6， Type 2， K-Cadherin (Fetal Kidney)，K-Cadherin，Cadherin-6，Kidney Cadherin，CAD6，KCAD
研究＆開発段階	Phase 3 Clinical

英語名	Cadherin-6
ターゲットの別称	Kidney cadherin，K-cadherin，Cadherin 6， Type 2， K-Cadherin (Fetal Kidney)，K-Cadherin，Cadherin-6，Kidney Cadherin，CAD6，KCAD
市販薬剤の数	0
治験薬の数	5
研究＆開発段階	Phase 3 Clinical

Cadherin-6 製品リスト

属性
Protein (9)Cell (1)Beads (1)
製品ライブラリ
オンライン (11)
種
Human (7)Cynomolgus / Rhesus macaque (2)Mouse (1)Rat (1)
タグ
His Tag (4)Fc Tag (4)His Tag & Avi Tag (1)- (2)
マーカー
Unconjugated (8)Biotin-labeled (1)- (2)

製品番号	種	発現システム	製品説明
HOT CA6-H5229	Human	HEK293	Human Cadherin-6 / KCAD / CDH6 Protein, His Tag, low endotoxin (HPLC verified)
HOT CA6-H5258	Human	HEK293	Human Cadherin-6 / KCAD / CDH6 Protein, Fc Tag (MALS verified)
HOT CA6-H82E3	Human	HEK293	Biotinylated Human Cadherin-6 / KCAD / CDH6 Protein, His,Avitag™ (MALS verified)
HOT CA6-C52H3	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus / Rhesus macaque Cadherin-6 / KCAD / CDH6 Protein, His Tag, low endotoxin
CA6-H5253	Human	HEK293	Human Cadherin-6 / KCAD / CDH6 (19-486) Protein, Fc Tag (MALS verified)
CA6-H5254	Human	HEK293	Human Cadherin-6 / KCAD / CDH6 (269-383) Protein, Fc Tag
CHEK-ATP127	Human	HEK293	HEK293/Human Cadherin-6 Stable Cell Line
MBC-K196	Human	-	Human Cadherin-6 coupled magnetic beads (2 µm)
CA6-M52H8	Mouse	HEK293	Mouse Cadherin-6 / KCAD / CDH6 Protein, His Tag
CA6-C5253	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus / Rhesus macaque Cadherin-6 / KCAD / CDH6 Protein, Fc Tag (MALS verified)

総数量11

Cadherin-6バックグランド

Cadherin-6 (CDH6) is also known as Kidney cadherin (K-cadherin or KCAD), is a a type II classical cadherin from the cadherin superfamily. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH6 / KCAD contains five cadherin domains. CDH6 is highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression and also expressed in certain liver and kidney carcinomas.

Cadherin-6分子の別称

CDH6,CAD6,KCAD,K-cadherin,Cadherin-6

抗体購入プラットフォーム

プロジェクト	ステージ	タイプ	由来	疾患領域	適応症
CDH6 mAb - 01	PCC	Monoclonal	Humanized Mouse	Solid Tumor	Ovarian cancer,Renal cell carcinoma

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Raludotatug deruxtecan	DS-6000a; DS6000a; DS-6000; R-DXd; MK-5909	Phase 3 Clinical	Daiichi Sankyo Co Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Fallopian Tube Neoplasms; Gastrointestinal Neoplasms; Lung Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Solid tumours	詳細
QLS-5133	QLS-5133; QLS5133	Phase 2 Clinical	Qilu Pharmaceutical Co Ltd	Solid tumours	詳細
HS-20124	HS-20124; HS20124	Phase 1 Clinical	Hansoh BioMedical R&D Company	Solid tumours	詳細
SIM-0505	SIM-0505	Phase 1 Clinical	Hainan Xiansheng Re Ming Pharmaceutical Co Ltd	Solid tumours	詳細
AMT-707	AMT-707; CUSP-06	Phase 1 Clinical	Multitude Therapeutics Inc	Carcinoma, Renal Cell; Cholangiocarcinoma; Ovarian Neoplasms; Solid tumours	詳細

レビュー

1***62022-08-09
1評価
Human Cadherin-6 / KCAD / CDH6 Protein, His Tag, low endotoxin (HPLC verified)
Validated by SPR, measured monovalent affinity, anti-human FC chip, load diluted antibody, added diluted CDH6, His tag, with the affinity constant of 4.72 nM.