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CBLB

CBLB 詳細

英語名	E3 ubiquitin-protein ligase CBL-B	市販薬剤の数	0
治験薬の数	3	ターゲットの別称	Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B，Casitas B-lineage lymphoma proto-oncogene b，RING-type E3 ubiquitin transferase CBL-B，SH3-binding protein CBL-B，RING finger protein 56，Nbla00127，RNF56，Signal transduction protein CBL-B，Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence B，Cbl Proto-Oncogene， E3 Ubiquitin Protein Ligase B，Cbl Proto-Oncogene B，Cbl Proto-Oncogene B， E3 Ubiquitin Protein Ligase，Cbl-B
研究＆開発段階	Phase 2 Clinical

英語名	E3 ubiquitin-protein ligase CBL-B
ターゲットの別称	Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B，Casitas B-lineage lymphoma proto-oncogene b，RING-type E3 ubiquitin transferase CBL-B，SH3-binding protein CBL-B，RING finger protein 56，Nbla00127，RNF56，Signal transduction protein CBL-B，Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence B，Cbl Proto-Oncogene， E3 Ubiquitin Protein Ligase B，Cbl Proto-Oncogene B，Cbl Proto-Oncogene B， E3 Ubiquitin Protein Ligase，Cbl-B
市販薬剤の数	0
治験薬の数	3
研究＆開発段階	Phase 2 Clinical

CBLB 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
His Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
CBB-H5148	Human	E. coli	Human CBLB / RNF56 Protein, His Tag

総数量1

CBLBバックグランド

Casitas B-lineage lymphoma proto-oncogene b (CBLB) is also known as RNF56. E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle.

CBLB分子の別称

CBL-B,CBLB,RNF56

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
HST-1011	HST-1011; HST1011	Phase 2 Clinical	HotSpot Therapeutics Inc	Neoplasms; Solid tumours	詳細
APN-401	APN-401	Phase 1 Clinical	Apeiron Biologics	Brain metastases; Carcinoma, Renal Cell; Colorectal Neoplasms; Melanoma; Neoplasm Metastasis; Pancreatic Neoplasms; Solid tumours	詳細
NX-1607	NX-1607	Phase 1 Clinical	Nurix Therapeutics Inc	Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Transitional Cell; Colorectal Neoplasms; Esophageal Neoplasms; Lymphoma, Large B-Cell, Diffuse; Mesothelioma; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Richter's Syndrome; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms	詳細