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CD109

CD109 詳細

英語名	DNA polymerase alpha subunit	市販薬剤の数	2
治験薬の数	3	ターゲットの別称	P180，N Syndrome (Mental Retardation， Malformations， Chromosome Breakage)，NSX，VEODS，Polymerase (DNA Directed)， Alpha，POLA1，Polymerase (DNA-Directed)， Alpha (70kD)，DNA Polymerase Alpha 1， Catalytic Subunit，POLA，EC:2.7.7.7，EC 2.7.7.7，DNA Polymerase Alpha Catalytic Subunit，DNA Polymerase Alpha Catalytic Subunit P180，Polymerase (DNA) Alpha 1， Catalytic Subunit，DNA Polymerase I，Polymerase (DNA Directed)， Alpha 1， Catalytic Subunit
研究＆開発段階	Approved

英語名	DNA polymerase alpha subunit
ターゲットの別称	P180，N Syndrome (Mental Retardation， Malformations， Chromosome Breakage)，NSX，VEODS，Polymerase (DNA Directed)， Alpha，POLA1，Polymerase (DNA-Directed)， Alpha (70kD)，DNA Polymerase Alpha 1， Catalytic Subunit，POLA，EC:2.7.7.7，EC 2.7.7.7，DNA Polymerase Alpha Catalytic Subunit，DNA Polymerase Alpha Catalytic Subunit P180，Polymerase (DNA) Alpha 1， Catalytic Subunit，DNA Polymerase I，Polymerase (DNA Directed)， Alpha 1， Catalytic Subunit
市販薬剤の数	2
治験薬の数	3
研究＆開発段階	Approved

CD109 製品リスト

属性
Protein (4)
製品ライブラリ
オンライン (4)
種
Human (3)Cynomolgus (1)
タグ
His Tag & Avi Tag (1)His Tag (2)Fc Tag (1)
マーカー
Biotin-labeled (1)Unconjugated (3)

製品番号	種	発現システム	製品説明
CD9-H5256	Human	HEK293	Human CD109 / CPAMD7 protein, Fc Tag
CD9-H52H3	Human	HEK293	Human CD109 / CPAMD7 Protein, His Tag
CD9-H82E4	Human	HEK293	Biotinylated Human CD109 / CPAMD7 Protein, His,Avitag™ (MALS & SPR verified)
CD9-C52H5	Cynomolgus	HEK293	Cynomolgus CD109 / CPAMD7 Protein, His Tag

総数量4

CD109バックグランド

CD109 is a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. CD109 is expressed in many malignant tumors, including various squamous cell carcinomas and adenocarcinomas, and plays a role as a multifunctional coreceptor.CD109 reportedly associates with transforming growth factor (TGF)-β receptors and negatively regulates TGF-β signaling in keratinocytes. Additionally, CD109 is potentially related to signal transducer and activator of transcription-3 signaling and aberrant cell proliferation.

CD109分子の別称

CD109,CPAMD7,r150,p180,CPAMD7

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Clofarabine (Boyen)	BY-101	Phase 3 Clinical	Boyen Therapeutics Inc	Leukemia, Myeloid, Acute	詳細
Alkasar-18	NOAC; Alkasar-18; N4-octadecyl-ara-C	Phase 1 Clinical	University of Zurich	Cerebral Hemorrhage; Neoplasms; Atrial Fibrillation	詳細
Sapacitabine	CS-682; CYC-682	Phase 1 Clinical	Daiichi Sankyo Co Ltd	Leukemia; Myelodysplastic Syndromes; Breast Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, T-Cell, Cutaneous; Carcinoma, Non-Small-Cell Lung	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Clofarabine	CAFdA; JC0707; GZ-393590; SAR-393590; 2-Cl-2-F-araA	Approved	Genzyme Corp	Clolar, Evoltra, Ivozall, Clofarex	United States	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Genzyme Corp	2004-12-28	Neoplasms; Angioimmunoblastic T-cell Lymphoma; Leukemia, Lymphocytic, Chronic, B-Cell; Waldenstrom Macroglobulinemia; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Lymphoma; Lymphoproliferative Disorders; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Histiocytosis, Langerhans-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Multiple Myeloma; Leukemia; Lymphoma, Large B-Cell, Diffuse; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Leukemia, Lymphoid; Intestinal Neoplasms; Lymphoma, T-Cell, Peripheral; Lymphoma, B-Cell, Marginal Zone; Lymphoma, B-Cell; Hematologic Neoplasms; Leukemia, Myeloid; Leukemia, Myelogenous, Chronic; Solid tumours	詳細
Nelarabine	506U; 506-U78; GW-506U; GW-506U78; GI-262250X; NSC-686673	Approved	Novartis Pharma Ag, Glaxosmithkline Plc	Arranon, ArranonG, Atriance	United States	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Sandoz	2005-10-28	Sezary Syndrome; Mycosis Fungoides; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, T-Cell; Angioimmunoblastic T-cell Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Cutaneous; Waldenstrom Macroglobulinemia; Lymphoma, T-Cell; Lymphoma, Non-Hodgkin; Lymphoma; Leukemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Follicular; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Multiple Myeloma; Leukemia-Lymphoma, Adult T-Cell; Myeloproliferative Disorders; Myelodysplastic Syndromes; Plasmacytoma; Lymphoma, B-Cell, Marginal Zone	詳細