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CD3 epsilon

CD3 epsilon 詳細

英語名	T-cell surface glycoprotein CD3 epsilon chain	市販薬剤の数	4
治験薬の数	7	ターゲットの別称	T-cell surface antigen T3/Leu-4 epsilon chain，CD3-Epsilon
研究＆開発段階	Approved

英語名	T-cell surface glycoprotein CD3 epsilon chain
ターゲットの別称	T-cell surface antigen T3/Leu-4 epsilon chain，CD3-Epsilon
市販薬剤の数	4
治験薬の数	7
研究＆開発段階	Approved

CD3 epsilon 製品リスト

属性
Protein (18)Beads (1)
製品ライブラリ
オンライン (19)
種
Human (10)Cynomolgus (5)Mouse (2)Canine (1)Rhesus macaque (1)
タグ
His Tag (8)His Tag & Fc Tag (2)Fc Tag (4)His Tag & Avi Tag (1)Mouse IgG Fc Tag (1)- (1)Fc Tag & Avi Tag (2)
マーカー
Unconjugated (10)Biotin-labeled (5)- (1)HRP Labeled (1)AF488 Labeled (2)

製品番号	種	発現システム	製品説明
HOT CDE-H5223	Human	HEK293	Human CD3 epsilon Protein, His Tag, low endotoxin (MALS verified)
HOT CDE-H8224	Human	HEK293	Biotinylated Human CD3 epsilon Protein, His Tag, ultra sensitivity (primary amine labeling) (MALS verified)
HOT CDE-H82E1	Human	HEK293	Biotinylated Human CD3 epsilon Protein, His,Avitag™
HOT CDN-H5253	Human	HEK293	Human CD3 epsilon Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
CDE-H5253	Human	HEK293	Human CD3 epsilon (23-48) Protein, Fc Tag, low endotoxin (MALS verified)
CDE-H5256	Human	HEK293	Human CD3 epsilon Protein, Fc,His Tag, low endotoxin (MALS verified)
CDE-H82F3	Human	HEK293	Biotinylated Human CD3 epsilon (23-48) Protein, Fc,Avitag™ (MALS verified)
CDE-HA2H3	Human	HEK293	Alexa Fluor™ 488-Labeled Human CD3 epsilon Protein, His Tag
CDE-HR2H4	Human	HEK293	HRP-Human CD3 epsilon Protein, His Tag
MBS-K026	Human	-	Human CD3E-coupled Magnetic Beads

総数量19

CD3 epsilonバックグランド

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

CD3 epsilon分子の別称

FLJ18683,T3E,TCRE,CD3E,CD3-epsilon

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Foralumab	NI-0401/α-CD3; TZLS-401; NI-0401	Phase 2 Clinical	Medarex Inc, Novimmune Sa	Alzheimer Disease; Amyotrophic Lateral Sclerosis; Cognitive Dysfunction; Coronavirus Disease 2019 (COVID-19); Crohn Disease; Dementia; Diabetes Mellitus, Type 2; Lower Respiratory Tract Infections; Metabolic Dysfunction-Associated Steatotic Liver Disease; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple System Atrophy; Rejection of renal transplantation	詳細
Obrindatamab	MGD-009; B7-H3 x CD3	Phase 2 Clinical	Macrogenics Inc	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colonic Neoplasms; Melanoma; Mesothelioma; Neuroblastoma; Neurofibrosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rhabdomyosarcoma; Sarcoma; Sarcoma, Synovial; Squamous Cell Carcinoma of Head and Neck; Thyroid Neoplasms; Urinary Bladder Neoplasms; Wilms Tumor	詳細
SOA-101	SOA-101; SOA101	Phase 2 Clinical	Shine-On BioMedical Co Ltd	Brain Neoplasms; Breast Neoplasms; Lung Neoplasms; Mouth Neoplasms; Ovarian Neoplasms; Solid tumours	詳細
Emerfetamab	AMG-673; AMG673	Phase 1 Clinical	Amgen Inc	Leukemia, Myeloid, Acute	詳細
Gresonitamab	AMG-910	Phase 1 Clinical	Amgen Inc	Adenocarcinoma; Esophageal Neoplasms; Stomach Neoplasms	詳細
Eluvixtamab	AMG-330; MT-114	Phase 1 Clinical	Amgen Inc	Leukemia, Myeloid, Acute; Myelodysplastic Syndromes	詳細
Linclatamig	BLYG-8824; BLYG-8824A; RG 6286	Phase 1 Clinical	Genentech Inc	Colorectal Neoplasms	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Tarlatamab	AMG-757	Approved	Amgen Inc	Imdelltra	United States	Small Cell Lung Carcinoma	Amgen Inc	2024-05-16	Astrocytoma; Brain metastases; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Ganglioglioma; Glioblastoma; Medullary thyroid cancer (MTC); Melanoma; Neoplasms; Neuroendocrine Tumors; Oligodendroglioma; Paranasal Sinus Diseases; Prostatic Neoplasms; Small Cell Lung Carcinoma; Testicular Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	詳細
Elranatamab	PF‑3135; RN-613; PF-06863135	Approved	Pfizer Inc	Elrexfio, ELREXFIO™, ELREXFIO	United States	Multiple Myeloma	Pfizer Inc	2023-08-14	Anemia, Hemolytic, Autoimmune; Bone Marrow Neoplasms; Immunoglobulin Light-chain Amyloidosis; Multiple Myeloma; Smoldering Multiple Myeloma; Spinal Cord Diseases	詳細
Glofitamab	RG-6026; RO-7082859; RG6026-2; RO6026	Approved	F. Hoffmann-La Roche Ltd	COLUMVI, 高罗华	Canada	Lymphoma, Large B-Cell, Diffuse	F. Hoffmann-La Roche Ltd	2023-03-25	Central Nervous System Lymphoma; Lymphoma; Lymphoma, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin	詳細
Talquetamab	JNJ-7564; JNJ-64407564	Approved	Genmab A/S, Johnson & Johnson Innovative Medicine	TALVEY, 拓立珂	United States	Multiple Myeloma	Janssen Biotech Inc	2023-08-09	Hematologic Neoplasms; Multiple Myeloma	詳細