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CD46

CD46 詳細

英語名	Membrane cofactor protein	市販薬剤の数	0
治験薬の数	5	ターゲットの別称	TLX，MCP，CD46，CD46 Molecule，Membrane Cofactor Protein (CD46， Trophoblast-Lymphocyte Cross-Reactive Antigen)，Antigen Identified By Monoclonal Antibody TRA-2-10，CD46 Molecule， Complement Regulatory Protein，CD46 Antigen， Complement Regulatory Protein，Trophoblast Leukocyte Common Antigen，MIC10，Trophoblast-Lymphocyte Cross-Reactive Antigen，Complement Membrane Cofactor Protein，Trophoblast Leucocyte Common Antigen，Measles Virus Receptor，CD46 Antigen，TRA2.10，AHUS2，Membrane cofactor protein，MGC26544
研究＆開発段階	Phase 2 Clinical

英語名	Membrane cofactor protein
ターゲットの別称	TLX，MCP，CD46，CD46 Molecule，Membrane Cofactor Protein (CD46， Trophoblast-Lymphocyte Cross-Reactive Antigen)，Antigen Identified By Monoclonal Antibody TRA-2-10，CD46 Molecule， Complement Regulatory Protein，CD46 Antigen， Complement Regulatory Protein，Trophoblast Leukocyte Common Antigen，MIC10，Trophoblast-Lymphocyte Cross-Reactive Antigen，Complement Membrane Cofactor Protein，Trophoblast Leucocyte Common Antigen，Measles Virus Receptor，CD46 Antigen，TRA2.10，AHUS2，Membrane cofactor protein，MGC26544
市販薬剤の数	0
治験薬の数	5
研究＆開発段階	Phase 2 Clinical

CD46 製品リスト

属性
Protein (5)
製品ライブラリ
オンライン (5)
種
Human (5)
タグ
His Tag (4)Fc Tag (1)
マーカー
Unconjugated (2)FITC Labeled (1)APC Labeled (1)PE Labeled (1)

製品番号	種	発現システム	製品説明
CD6-H5226	Human	HEK293	Human CD46 Protein, His Tag, low endotoxin (MALS verified)
CD6-H5254	Human	HEK293	Human CD46 Protein, Fc Tag (MALS verified)
CD6-HA224	Human	HEK293	APC-Labeled Human CD46 Protein, His Tag
CD6-HF223	Human	HEK293	FITC-Labeled Human CD46 Protein, His Tag
CD6-HP223	Human	HEK293	PE-Labeled Human CD46 Protein, His Tag

総数量5

CD46バックグランド

Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).

CD46分子の別称

CD46,AHUS2,MCP,MIC10,TLX,TRA2.10

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Anti-CD46 antibody drug conjugate (Fortis Therapeutics)	FG-3246; FOR-46	Phase 2 Clinical	University Of California San Diego	Multiple Myeloma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant	詳細
Enadenotucirev	ColoAd-1; Oncolytic Ad11/Ad3	Phase 1 Clinical	Akamis Bio Ltd	Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Colorectal Neoplasms; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Rectal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Urinary Bladder Neoplasms	詳細
AugmAb	BRM-132	Phase 1 Clinical	Compliment Corp	Lymphoma, Non-Hodgkin; Neoplasms	詳細
YS-5	YS-5	Phase 1 Clinical	Fortis Therapeutics Inc, United States Department Of Defense	Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant	詳細
FG-3180	89Zr-DFO-YS-5; 89Zr-DFO-YS5	Phase 1 Clinical	Fortis Therapeutics Inc	Multiple Myeloma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant	詳細