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CD74

CD74 詳細

英語名	HLA-DR antigens-associated invariant chain	市販薬剤の数	0
治験薬の数	5	ターゲットの別称	CLIP，CD74，Ia antigen-associated invariant chain，CD74 Molecule，CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex， Class II Antigen-Associated)，CD74 Molecule， Major Histocompatibility Complex， Class II Invariant Chain，HLA-DR Antigens-Associated Invariant Chain，Ia-Associated Invariant Chain，MHC HLA-DR Gamma Chain，HLA-DR-Gamma，DHLAG，P33，CD74 Antigen，Ia-GAMMA，HLADG，II，Gamma Chain Of Class II Antigens，HLA Class II Histocompatibility Antigen Gamma Chain
研究＆開発段階	Phase 1 Clinical

英語名	HLA-DR antigens-associated invariant chain
ターゲットの別称	CLIP，CD74，Ia antigen-associated invariant chain，CD74 Molecule，CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex， Class II Antigen-Associated)，CD74 Molecule， Major Histocompatibility Complex， Class II Invariant Chain，HLA-DR Antigens-Associated Invariant Chain，Ia-Associated Invariant Chain，MHC HLA-DR Gamma Chain，HLA-DR-Gamma，DHLAG，P33，CD74 Antigen，Ia-GAMMA，HLADG，II，Gamma Chain Of Class II Antigens，HLA Class II Histocompatibility Antigen Gamma Chain
市販薬剤の数	0
治験薬の数	5
研究＆開発段階	Phase 1 Clinical

CD74 製品リスト

属性
Protein (3)
製品ライブラリ
オンライン (3)
種
Human (3)
タグ
His Tag (1)Fc Tag (1)Llama IgG Fc Tag (1)
マーカー
Unconjugated (3)

製品番号	種	発現システム	製品説明
CD4-H524c	Human	HEK293	Human CD74 / DHLAG Protein, His Tag, low endotoxin (HPLC verified)
CD4-H5256	Human	HEK293	Human CD74 / DHLAG Protein, Fc Tag (MALS verified)
CD4-H5258	Human	HEK293	Human CD74 / DHLAG Protein, Llama IgG2b Fc Tag, low endotoxin

総数量3

CD74バックグランド

Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.

CD74分子の別称

CD74,DHLAG,HLADG,II,Ia-GAMMA,p33,CLIP,INVG34

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Influenza A M1 vaccine (Pascal Biosciences)		Phase 1 Clinical	Pascal Biosciences	Influenza A virus infections	詳細
adenovector based vaccine (Pascal Biosciences/University of British Columbia)		Phase 1 Clinical	Nevis Brands Inc	Influenza A virus infections	詳細
90Y-2IT-BAD-Lym-1	90Y-2IT-BAD-Lym-1	Phase 1 Clinical	National Cancer Institute	Lymphoma, Non-Hodgkin	詳細
Bezetabart debotansine	STRO-001; SP7675; SP-7675; BN-301	Phase 1 Clinical	Sutro Biopharma Inc	Hematologic Neoplasms; Lymphoma, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Multiple Myeloma	詳細
TROP-2-targeted anti-CD74 siRNA (Immunomedics)			Immunomedics Inc	Solid tumours	詳細