言語を選択

CD79B

CD79B 詳細

英語名	B-cell antigen receptor complex-associated protein beta chain	市販薬剤の数	1
治験薬の数	9	ターゲットの別称	B-Cell Antigen Receptor Complex-Associated Protein Beta Chain，B29，Immunoglobulin-associated B29 protein，Ig-beta，B-cell-specific glycoprotein B29，CD79B，CD79b Molecule，CD79b Molecule， Immunoglobulin-Associated Beta，IGB，CD79B Antigen (Immunoglobulin-Associated Beta)，CD79b Antigen，AGM6
研究＆開発段階	Approved

英語名	B-cell antigen receptor complex-associated protein beta chain
ターゲットの別称	B-Cell Antigen Receptor Complex-Associated Protein Beta Chain，B29，Immunoglobulin-associated B29 protein，Ig-beta，B-cell-specific glycoprotein B29，CD79B，CD79b Molecule，CD79b Molecule， Immunoglobulin-Associated Beta，IGB，CD79B Antigen (Immunoglobulin-Associated Beta)，CD79b Antigen，AGM6
市販薬剤の数	1
治験薬の数	9
研究＆開発段階	Approved

CD79B 製品リスト

属性
Protein (9)Cell (1)
製品ライブラリ
オンライン (10)
種
Human (5)Mouse (3)Cynomolgus (2)
タグ
Fc Tag (2)His Tag (4)His Tag & Avi Tag (3)- (1)
マーカー
Unconjugated (5)Biotin-labeled (3)PE Labeled (1)- (1)

製品番号	種	発現システム	製品説明
HOT CDB-H5259	Human	HEK293	Human CD79B Protein, Fc Tag, low endotoxin
HOT CDB-H52H3	Human	HEK293	Human CD79B Protein, His Tag, low endotoxin (MALS verified)
HOT CDB-H82E3	Human	HEK293	Biotinylated Human CD79B Protein, His,Avitag™ (MALS verified)
HOT CDB-HP2H6	Human	HEK293	PE-Labeled Human CD79B Protein, His Tag (Site-specific conjugation)
SCCHO-ATP171	Human	CHO	CHO/Human CD79B Stable Cell Line
CDB-M5253	Mouse	HEK293	Mouse CD79B Protein, Fc Tag (MALS verified)
CDB-M52H4	Mouse	HEK293	Mouse CD79B Protein, His Tag, low endotoxin (MALS verified)
CDB-M82E3	Mouse	HEK293	Biotinylated Mouse CD79B Protein, His,Avitag™ (MALS verified)
CDB-C52H3	Cynomolgus	HEK293	Cynomolgus CD79B Protein, His Tag (MALS verified)
CDB-C82E5	Cynomolgus	HEK293	Biotinylated Cynomolgus CD79B Protein, His,Avitag™

総数量10

CD79Bバックグランド

B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.

CD79B分子の別称

CD79b,B29,IGB,Ig-beta

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
SHR-A1912	SHR-A1912	Phase 3 Clinical	Shanghai Hengrui Pharmaceutical Co Ltd	Lymphoma; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse	詳細
CD19/79b Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute)	bi-4SCAR CD19/79b	Phase 2 Clinical	Shenzhen Geno-Immune Medical Institute	Leukemia, B-Cell; Lymphoma, B-Cell	詳細
TolDCB29		Phase 2 Clinical	Umc Utrecht	Arthritis, Rheumatoid	詳細
JNJ-95566692	JNJ-95566692	Phase 1 Clinical	Janssen Research & Development Llc	Lymphoma, Non-Hodgkin	詳細
LTZ-301	LTZ-301	Phase 1 Clinical	LTZ Therapeutics Inc	Autoimmune Diseases; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin	詳細
CD79b-19 CAR T Cells Therapy (Massachusetts General Hospital)		Phase 1 Clinical	Massachusetts General Hospital	Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Primary mediastinal B cell lymphoma	詳細
Autologous CD79b-targeting Chimeric Antigen Receptor T-cell Therapy（MD Anderson Cancer Center）	JV-213	Phase 1 Clinical	The University Of Texas MD Anderson Cancer Center	Lymphoma; Lymphoma, B-Cell	詳細
NBT-508		Phase 1 Clinical	Newbio Therapeutics Inc	Lymphoma, B-Cell; Lymphoma, Non-Hodgkin	詳細
CD79b CAR-T cell therapy (Yake Biotechnology)		Phase 1 Clinical	Shanghai YaKe Biotechnology Co Ltd, Zhejiang University	Leukemia, Biphenotypic, Acute; Lymphoma, Non-Hodgkin; Precursor Cell Lymphoblastic Leukemia-Lymphoma	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Polatuzumab vedotin	RO-5541077-000; FCU-2711; DCDS-4501A; RG-7596; RO-5541077	Approved	Genentech Inc, Seagen Inc	Polivy, 优罗华	United States	Lymphoma, Large B-Cell, Diffuse	Genentech Inc	2019-06-10	Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Lymphoma, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin	詳細