CD99

CD99

CD99 Overview

Molecule Name
CD99 antigen
Synonyms
CD99,HBA71,MIC2,MIC2X,MIC2Y,MSK5X,12E7
Drug Development Progress
Drugs in Clinical Trials1
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
12E7,E2 antigen,Protein MIC2,T-cell surface glycoprotein E2
Background
CD99 antigen is also known as MIC2, single-chain type-1 glycoprotein, HBA71, MIC2X, MIC2Y, MSK5X, 12E7, which belongs to the CD99 family. CD99 / MIC2 is expressed on all leukocytes but highest on thymocytes. Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. CD99 / MIC2 plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. CD99 acts at the same site as, but independently of PECAM1. There is also experimental evidence that it binds to cyclophilin A.

CD99 Product List

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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
Anti-CD99 CAR T-cell therapy (Wuhan Bio-Raid)BRD-03Phase 2 ClinicalWuhan BioRaid Biotechnology Co Ltd
Osteosarcoma; Sarcoma
Details