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CEACAM-6

CEACAM-6 詳細

英語名	Carcinoembryonic antigen related cell adhesion molecule 6	市販薬剤の数	0
治験薬の数	3	ターゲットの別称	CEACAM6，CD66c，NCA，Carcinoembryonic Antigen Related Cell Adhesion Molecule 6，Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (Non-Specific Cross Reacting Antigen)，Normal Cross-Reacting Antigen，Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6，Non-Specific Crossreacting Antigen，Cluster Of Differentiation 66c，CD66c Antigen，CEAL，CEA Cell Adhesion Molecule 6
研究＆開発段階	Phase 2 Clinical

英語名	Carcinoembryonic antigen related cell adhesion molecule 6
ターゲットの別称	CEACAM6，CD66c，NCA，Carcinoembryonic Antigen Related Cell Adhesion Molecule 6，Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (Non-Specific Cross Reacting Antigen)，Normal Cross-Reacting Antigen，Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6，Non-Specific Crossreacting Antigen，Cluster Of Differentiation 66c，CD66c Antigen，CEAL，CEA Cell Adhesion Molecule 6
市販薬剤の数	0
治験薬の数	3
研究＆開発段階	Phase 2 Clinical

CEACAM-6 製品リスト

属性
Protein (5)
製品ライブラリ
オンライン (5)
種
Human (4)Rhesus macaque (1)
タグ
His Tag (2)His Tag & Avi Tag (1)Fc Tag (1)Fc Tag & Avi Tag (1)
マーカー
Unconjugated (3)Biotin-labeled (2)

製品番号	種	発現システム	製品説明
HOT CE6-H5223	Human	HEK293	Human CEACAM-6 / CD66c Protein, His Tag, low endotoxin
HOT CE6-H5254	Human	HEK293	Human CEACAM-6 / CD66c Protein, Fc Tag, low endotoxin (MALS verified)
HOT CE6-H82E7	Human	HEK293	Biotinylated Human CEACAM-6 / CD66c Protein, His,Avitag™ (MALS verified)
HOT CE6-H82F6	Human	HEK293	Biotinylated Human CEACAM-6 / CD66c Protein, Fc,Avitag™ (MALS verified)
HOT CE6-R52H6	Rhesus macaque	HEK293	Rhesus macaque CEACAM-6 / CD66c Protein, His Tag

総数量5

CEACAM-6バックグランド

Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (CEACAM6) is also known as CD66c (Cluster of Differentiation 66c), CEAL, NCA, and is one of seven human CEACAM family members within the immunoglobulin superfamily. In humans, CEACAMs include type I transmembrane proteins (CEACAM1, CEACAM3, and CEACAM4) and GPI-linked molecules (CEACAM5 through CEACAM8). There is no human CEACAM2. CEACAM 6 contains one N-terminal V-type Ig-like domain (N domain), followed by two C2-type Ig-like domains. It shows considerable glycosylation, including (sialyl) LewisX, which mediates binding to E-selectin, galectins and some bacterial fimbrae. CEACAM-6 is expressed by granulocytes and their progenitors. It is also expressed by epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas, as well as hyperplastic polyps. Resistance to adhesion-related apoptosis in tumor cells is conferred in the condition of CEACAM6 overexpression.

CEACAM-6分子の別称

CEACAM6,CD66c,CEAL,NCA

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
NEO-201	NEO-201	Phase 2 Clinical	National Cancer Institute, Precision Biologics Inc	Carcinoma, Non-Small-Cell Lung; Squamous Cell Carcinoma of Head and Neck; Uterine Cervical Neoplasms; Uterine Neoplasms	詳細
EBC-129	EBC129; EBC-129	Phase 1 Clinical	Experimental Drug Development Centre	Solid tumours	詳細
DNP-002	DNP-002	Phase 1 Clinical	Dinona	Solid tumours	詳細