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CLEC7A

CLEC7A 詳細

英語名	C-type lectin domain family 7 member A	市販薬剤の数	0
治験薬の数	1	ターゲットの別称	C-type lectin superfamily member 12，Beta-glucan receptor，CD369，Dendritic cell-associated C-type lectin 1，DC-associated C-type lectin 1，BGR，CANDF4，C-Type (Calcium Dependent， Carbohydrate-Recognition Domain) Lectin， Superfamily Member 12，SCARE2，HDectin-1，CD369 Antigen，Dendritic Cell-Associated C-Type Lectin-1，DECTIN1，C-Type Lectin Domain Family 7， Member A，Lectin-Like Receptor 1，CLECSF12，Dectin-1，C-Type Lectin Domain Containing 7A
研究＆開発段階	Clinical

英語名	C-type lectin domain family 7 member A
ターゲットの別称	C-type lectin superfamily member 12，Beta-glucan receptor，CD369，Dendritic cell-associated C-type lectin 1，DC-associated C-type lectin 1，BGR，CANDF4，C-Type (Calcium Dependent， Carbohydrate-Recognition Domain) Lectin， Superfamily Member 12，SCARE2，HDectin-1，CD369 Antigen，Dendritic Cell-Associated C-Type Lectin-1，DECTIN1，C-Type Lectin Domain Family 7， Member A，Lectin-Like Receptor 1，CLECSF12，Dectin-1，C-Type Lectin Domain Containing 7A
市販薬剤の数	0
治験薬の数	1
研究＆開発段階	Clinical

CLEC7A 製品リスト

属性
Protein (7)
製品ライブラリ
オンライン (7)
種
Human (2)Cynomolgus (2)Mouse (3)
タグ
His Tag (4)His Tag & Avi Tag (2)Fc Tag (1)
マーカー
Unconjugated (5)Biotin-labeled (2)

製品番号	種	発現システム	製品説明
CL7-H5243	Human	HEK293	Human CLEC7A Protein, His Tag, low endotoxin (MALS verified)
CL7-H5248	Human	HEK293	Human CLEC7A Protein, His Tag, low endotoxin (MALS verified)
CL7-M5243	Mouse	HEK293	Mouse CLEC7A Protein, His Tag (HPLC verified)
CL7-M82Q3	Mouse	HEK293	Biotinylated Mouse CLEC7A Protein, Avitag™,His Tag (MALS verified)
CLA-M5263	Mouse	HEK293	Mouse CLEC7A Protein, Fc Tag (MALS verified)
CL7-C5243	Cynomolgus	HEK293	Cynomolgus CLEC7A Protein, His Tag, low endotoxin (MALS verified)
CLA-C82Q3	Cynomolgus	HEK293	Biotinylated Cynomolgus CLEC7A Protein, His,Avitag™ (MALS verified)

総数量7

CLEC7Aバックグランド

Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11567029, PubMed:12423684). Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Enhances cytokine production in macrophages and dendritic cells (By similarity). Mediates production of reactive oxygen species in the cell (By similarity). Mediates phagocytosis of C.albicans conidia (PubMed:17230442). Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity).