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Coagulation Factor III

Coagulation Factor III 詳細

英語名	Tissue factor	市販薬剤の数	1
治験薬の数	7	ターゲットの別称	Coagulation Factor III (Thromboplastin， Tissue Factor)，Thromboplastin，Coagulation Factor III， Tissue Factor，TFA，F3，TF，CD142 Antigen，CD142，Coagulation Factor III，Tissue Factor
研究＆開発段階	Approved

英語名	Tissue factor
ターゲットの別称	Coagulation Factor III (Thromboplastin， Tissue Factor)，Thromboplastin，Coagulation Factor III， Tissue Factor，TFA，F3，TF，CD142 Antigen，CD142，Coagulation Factor III，Tissue Factor
市販薬剤の数	1
治験薬の数	7
研究＆開発段階	Approved

Coagulation Factor III 製品リスト

属性
Protein (7)
製品ライブラリ
オンライン (7)
種
Human (4)Mouse (1)Cynomolgus (1)Canine (1)
タグ
His Tag (4)Fc Tag (1)His Tag & Avi Tag (1)Fc Tag & Avi Tag (1)
マーカー
Unconjugated (5)Biotin-labeled (2)

製品番号	種	発現システム	製品説明
HOT TF3-H5253	Human	HEK293	Human Coagulation Factor III / Tissue Factor Protein, Fc Tag (active enzyme, MALS verified)
HOT TF3-H52H5	Human	HEK293	Human Coagulation Factor III / Tissue Factor Protein, His Tag, low endotoxin (active enzyme, MALS verified)
HOT TF3-M52H3	Mouse	HEK293	Mouse Coagulation Factor III / Tissue Factor Protein, His Tag (MALS verified)
TF3-H82E3	Human	HEK293	Biotinylated Human Coagulation Factor III / Tissue Factor Protein, His,Avitag™ (MALS & SPR verified)
TF3-H82F3	Human	HEK293	Biotinylated Human Coagulation Factor III / Tissue Factor Protein, Fc,Avitag™ (MALS & SPR verified)
TF3-C52H3	Cynomolgus	HEK293	Cynomolgus Coagulation Factor III / Tissue Factor Protein, His Tag (active enzyme, MALS verified)
TF3-C52H4	Canine	HEK293	Canine Coagulation Factor III / Tissue Factor Protein, His Tag (MALS verified)

総数量7

Coagulation Factor IIIバックグランド

Full-length tissue factor (TF) is a transmembrane receptor and cofactor for factor (F)VII/FVIIa. In addition to full-length TF, an alternative spliced (as) form of TF can be generated that lacks the transmembrane domain and is released fromcells. In contrast to TF, asTF has low procoagulant activity because it lacks the transmembrane domain. Tissue factor is expressed by cells around blood vessels, such as adventitial fibroblasts, and body surfaces, such as epithelial cells, and plays a critical role in hemostasis. TF also contributes to various forms of thrombosis. Many cancers, particularly adenocarcinomas, express high levels of TF. A high level of tumor TF expression is associated with poor prognosis in many types of cancers, including breast, prostate, colorectal, and pancreatic cancer.

Coagulation Factor III分子の別称

Coagulation Factor III,Tissue Factor,TF,F3,CD142

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Anpocogin	AB-201	Phase 3 Clinical	Dendreon Uk Ltd	Coronavirus Disease 2019 (COVID-19)	詳細
XNW-28012	XNW-28012; XNW28012	Phase 3 Clinical	Shanghai Cigna Biotech Pharmaceutical Co Ltd	Ovarian Neoplasms; Pancreatic Neoplasms; Solid tumours; Uterine Cervical Neoplasms	詳細
MRG-004A	MRG004A	Phase 3 Clinical	Shanghai Miracogen Inc	Pancreatic Neoplasms; Solid tumours	詳細
XB-002	XB-002; ICON-2	Phase 1 Clinical	Iconic Therapeutics Inc	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Endometrial Neoplasms; Esophageal Squamous Cell Carcinoma; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Urogenital Neoplasms; Uterine Cervical Neoplasms	詳細
XB-371	XB-371; XB371	Phase 1 Clinical	Catalent Inc, Exelixis Inc	Neoplasms; Solid tumours	詳細
STRO-004	STRO-004	Phase 1 Clinical	Sutro Biopharma Inc	Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Uterine Cervical Neoplasms	詳細
AMT-754	ADCE-T02; AMT-754	Phase 1 Clinical	Multitude Therapeutics Inc	Solid tumours	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Tisotumab vedotin	TF-011-MMAE	Approved	Genmab A/S	HuMax-TF, TIVDAK	United States	Uterine Cervical Neoplasms	Seagen Inc	2021-09-20	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	詳細