Coagulation factor VII 詳細
Molecule Name
Coagulation factor VII
分子の別称
Coagulation factor VII,F7,SPCA,Proconvertin
Drug Development Progress
治験薬の数8
市販薬剤の数22
研究＆開発段階Approved
ターゲットの別称
EC 3.4.21，Eptacog alfa，F7，Coagulation Factor VII，Coagulation Factor VII (Serum Prothrombin Conversion Accelerator)，FVII Coagulation Protein，SPCA，EC 3.4.21.21，Factor VII，Proconvertin，Serum prothrombin conversion accelerator，EC:3.4.21.21
バックグランド
Coagulation factor VII is also known as F7, SPCA and Proconvertin. Heterodimer of a light chain and a heavy chain linked by a disulfide bond. Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
Coagulation factor VII 製品リスト
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治験薬に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|
| Human prothrombin complex (National Drug Group Wuhan Blood) | Phase 3 Clinical | Sinopharm Wuhan Biopharmaceutical Co Ltd | Hemophilia B; Hemorrhage | 詳細 | |
| Human prothrombin complex concentrate (Sichuan Yuanda Shuyang Pharmaceutical) | Phase 3 Clinical | Yuanda Shuyang Life Sciences (Chengdu) Co Ltd | Blood Coagulation Disorders | 詳細 | |
| Human prothrombin complex concentrate (Harbin Shiheng Bioengineering Pharmaceutical) | Phase 3 Clinical | Harbin Pacific Biopharmaceutical Co Ltd | Hemophilia B | 詳細 | |
| Human prothrombin complex(Hunan Ziguang Huhan Nanyue Pharmaceutical) | Phase 3 Clinical | Hunan Ziguang Huhan Nanyue Pharmaceutical Co Ltd | Hemophilia B | 詳細 | |
| Factor VII (KM Biologics) | KD2-305 | Phase 3 Clinical | KM Biologics Co Ltd | Hemophilia A | 詳細 |
| Sutacimig | HMB001; HMB-001 | Phase 2 Clinical | Hemab Therapeutics APS | Factor VII Deficiency; Thrombasthenia | 詳細 |
| SIG-001(Sigilon) | Sig-001(Sigilon) | Phase 2 Clinical | Sigilon Therapeutics Inc | Hemophilia A | 詳細 |
| recombinant coagulation factor VIIa (Chengdu Rongsheng Pharmaceuticals) | Phase 1 Clinical | Chengdu Rongsheng Pharmaceuticals Co Ltd | Hemophilia A; Hemophilia B | 詳細 |
市販薬剤に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | オリジナル製品名 | 最初に承認をした国 | 最初の適応症 | 最初に承認を受けた会社 | 承認された日付 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|---|---|---|---|---|
| Anti-inhibitor coagulant complex (Baxalta) | Approved | Baxalta Incorporated | PROPLEX 600, Prothromplex, Prothromplex 600, Prothromplex 600 IE, Prothromplex 600 SV, Prothromplex 600 TV, Prothromplex 600 UI, Prothromplex NF 600, PROPLEX, Feiba, Prothromplex TOTAL | United States | Hemophilia B; Hemophilia A | Baxalta Incorporated | 1979-12-21 | Blood Coagulation Disorders; Blood Coagulation Disorders, Inherited; Cardiovascular Diseases; Heart Diseases; Hemophilia A; Hemophilia B; Hemorrhage | 詳細 | |
| Human prothrombin complex (Nanyue Biopharming) | Approved | Hunan Ziguang Huhan Nanyue Pharmaceutical Co Ltd | Mainland China | Hemorrhage | Hunan Ziguang Huhan Nanyue Pharmaceutical Co Ltd | 2019-09-05 | Hemophilia B; Hemorrhage | 詳細 | ||
| Human prothrombin complex (CSL Behring) | BE-1116 | Approved | Csl Behring Llc | Kcentra, Beriplex, Confidex | Japan | Vitamin K Deficiency Bleeding | Csl Behring Kk | Blood Coagulation Disorders; Coagulation Protein Disorders; Heart Diseases; Heart Failure; Hemorrhage; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Vitamin K Deficiency Bleeding; Wounds and Injuries | 詳細 | |
| Human prothrombin complex concentrate (Guizhou Taibang Biological Products) | Approved | Guizhou Taibang Biological Products Co Ltd | Mainland China | Hypoprothrombinemias | Guizhou Taibang Biological Products Co Ltd | 2013-07-31 | Hypoprothrombinemias | 詳細 | ||
| Prothrombinex-VF (CSL Behring) | Approved | Csl Behring Llc | Australia | Hemorrhage | Csl Behring Llc | 2014-10-01 | Hemorrhage | 詳細 | ||
| Prothrombin complex concentrate (Sanquin) | Approved | Sanquin Plasma Products Bv | Cofact | Hemorrhage | Sanquin Plasma Products Bv | 2007-11-01 | Hemorrhage | 詳細 | ||
| Factor IX complex (Grifols) | Approved | Grifols Sa | Profilnine | United States | Hemophilia B | null | 1981-07-21 | Hemophilia B; Intracranial Hemorrhages | 詳細 | |
| Human prothrombin complex (Octapharma) | Approved | Octapharma | Ocplex, Octaplex, Pronativ | Germany | Hemorrhage | Octapharma | 2003-03-14 | Hemorrhage; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 詳細 | |
| Human prothrombin complex (LFB) | Approved | Lfb Biotechnologies Sas | KANOKAD | France | Hemorrhage | Lfb Biotechnologies Sas | 2008-09-01 | Hemorrhage | 詳細 | |
| Human prothrombin complex (Tonrol Biopharmaceuticals) | Approved | Tonrol Bio-Pharmaceutical Co Ltd | ProthoRAAS | Mainland China | Hemorrhage | Shanghai Raas Blood Products Co Ltd | 1996-01-01 | Hemophilia B; Hemorrhage | 詳細 | |
| Human prothrombin complex (ShenzhenWeiguang Biological Products) | Approved | Shenzhen Weiguang Biological Products Co Ltd | Mainland China | Hemorrhage | Shenzhen Weiguang Biological Products Co Ltd | 2024-05-21 | Hemophilia B; Hemorrhage | 詳細 | ||
| Human prothrombin complex (Guangdong Shuanglin) | Approved | Guangdong Shuanglin Bio-Pharmaceutical Co Ltd | Mainland China | Hemophilia B | Guangdong Shuanglin Bio-Pharmaceutical Co Ltd | 2023-05-12 | Hemophilia B | 詳細 | ||
| Human prothrombin complex (Shanghai Xinxing) | Approved | Shanghai Xinxing Medicine Co Ltd | Mainland China | Hemorrhage | Shanghai Xinxing Medicine Co Ltd | 1997-01-01 | Hemorrhage | 詳細 | ||
| Human prothrombin complex (Sinopharm Shanghai Plasma) | Approved | Sinopharm Shanghai Plasma-Derived Biotherapies Co Ltd | Mainland China | Hemorrhage | Sinopharm Shanghai Plasma-Derived Biotherapies Co Ltd | 1997-01-01 | Hemorrhage | 詳細 | ||
| Human prothrombin complex (Boya Bio-Pharmaceutical) | Approved | Boya Bio-Pharmaceutical Group Co Ltd | Mainland China | Hemorrhage | Boya Bio-Pharmaceutical Group Co Ltd | 2020-12-02 | Hemophilia B; Hemorrhage | 詳細 | ||
| Human prothrombin complex (Guangdong Wellen) | Approved | Guangdong Wellen Pharmaceutical Co Ltd | Mainland China | Hemorrhage | Guangdong Wellen Pharmaceutical Co Ltd | 2020-10-21 | Hemophilia B; Hemorrhage | 詳細 | ||
| Human prothrombin complex (Lanzhou Lansheng Blood Products) | Approved | Lanzhou Lansheng Blood Products Co Ltd | Mainland China | Hemophilia B | Lanzhou Lansheng Blood Products Co Ltd | 2024-09-26 | Hemophilia B | 詳細 | ||
| Human prothrombin complex(Chengdu Rongsheng Pharmaceuticals) | Approved | Chengdu Rongsheng Pharmaceuticals Co Ltd | Mainland China | Coagulation Protein Disorders | Chengdu Rongsheng Pharmaceuticals Co Ltd | 2020-12-15 | Coagulation Protein Disorders; Hemophilia B | 詳細 | ||
| Human prothrombin complex(Hebei Daan Pharmaceutical) | Approved | Hebei Daan Pharmaceutical Co Ltd | Mainland China | Hemorrhage | Hebei Daan Pharmaceutical Co Ltd | 2020-01-01 | Hemophilia B; Hemorrhage | 詳細 | ||
| Prothrombin complex concentrat (Taibang Biological Products) | Approved | Shandong Taibang Biological Products Co Ltd | Mainland China | Hemorrhage | Shandong Taibang Biological Products Co Ltd | 2014-09-30 | Antithrombin III Deficiency; Hemorrhage | 詳細 | ||
| Human prothrombin complex (Hualan Biological Engineering) | Approved | Hualan Ankang Biotechnology Co Ltd | Mainland China | Factor X Deficiency; Blood Coagulation Disorders | Hualan Biological Engineering Inc | 1999-01-01 | Blood Coagulation Disorders; Factor X Deficiency; Hemophilia B | 詳細 | ||
| Human prothrombin complex concentrate (Shanxi Kangbao Biological Products) | Approved | Shanxi Kangbao Biological Product Co Ltd | Mainland China | Hemorrhage | Shanxi Kangbao Biological Product Co Ltd | 2019-09-17 | Hemophilia B; Hemorrhage | 詳細 |