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COMP

COMP 詳細

英語名	Sodium channel protein type VIII alpha subunit	市販薬剤の数	1
治験薬の数	4	ターゲットの別称	Sodium Channel， Voltage Gated， Type VIII Alpha Subunit，Voltage-Gated Sodium Channel Type VIII Alpha Protein，HNa6/Scn8a Voltage-Gated Sodium Channel，CERIII，EIEE13，Nav1.6，BFIS5，NaCh6，CIAT，PN4，NAV1.6 Voltage-Gated Sodium Channel，MYOCL2，Sodium channel protein type 8 subunit alpha，Sodium channel protein type VIII subunit alpha，MED，SCN8A，Sodium Voltage-Gated Channel Alpha Subunit 8，Sodium Channel， Voltage Gated， Type VIII， Alpha Subunit，Voltage-Gated Sodium Channel Subunit Alpha Nav1.6，Sodium Channel， Voltage Gated， Type VIII， Alpha Polypeptide
研究＆開発段階	Approved

英語名	Sodium channel protein type VIII alpha subunit
ターゲットの別称	Sodium Channel， Voltage Gated， Type VIII Alpha Subunit，Voltage-Gated Sodium Channel Type VIII Alpha Protein，HNa6/Scn8a Voltage-Gated Sodium Channel，CERIII，EIEE13，Nav1.6，BFIS5，NaCh6，CIAT，PN4，NAV1.6 Voltage-Gated Sodium Channel，MYOCL2，Sodium channel protein type 8 subunit alpha，Sodium channel protein type VIII subunit alpha，MED，SCN8A，Sodium Voltage-Gated Channel Alpha Subunit 8，Sodium Channel， Voltage Gated， Type VIII， Alpha Subunit，Voltage-Gated Sodium Channel Subunit Alpha Nav1.6，Sodium Channel， Voltage Gated， Type VIII， Alpha Polypeptide
市販薬剤の数	1
治験薬の数	4
研究＆開発段階	Approved

COMP 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
His Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
COP-H5220	Human	HEK293	Human COMP / TSP5 Protein, His Tag

総数量1

COMPバックグランド

Cartilage oligomeric matrix protein (COMP) is also known as Thrombospondin-5 (TSP5), EDM1, EPD1, MED, PSACH, THBS5, which belongs to the thrombospondin family. COMP / TSP5 contains 4 EGF-like domains, 1 TSP C-terminal (TSPC) domain, 8 TSP type-3 repeats. Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. COMP may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. COMP can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Thrombospondin-5 could play a role in the pathogenesis of osteoarthritis. COMP is a marker of cartilage turnover.

COMP分子の別称

COMP,TSP5,EDM1,EPD1,MED,PSACH,THBS5

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
PRAX-562	PRAX-562	Phase 3 Clinical	Praxis Precision Medicines	Brain Diseases; Epilepsy	詳細
XEN-901	NBI-921352; XEN-901	Phase 2 Clinical	Xenon Pharma	Epilepsies, Partial; Brain Diseases; Epilepsy	詳細
PRAX-330	GS-458967; GS-967; PRAX-330	Phase 1 Clinical	Praxis Precision Medicines Inc	Epilepsy	詳細
NBI-355	NBI-355	Phase 1 Clinical	Neurocrine Biosciences Inc	Epilepsy	詳細