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CTLA-4

CTLA-4 詳細

英語名	Cytotoxic T-Lymphocyte-Associated Antigen 4	市販薬剤の数	5
治験薬の数	64	ターゲットの別称	Celiac Disease 3，Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4，Cytotoxic T-Lymphocyte Protein 4，CD152，Cytotoxic T-lymphocyte-associated antigen 4，CTLA4，CTLA-4，Cytotoxic T-Lymphocyte Associated Protein 4，Insulin-Dependent Diabetes Mellitus 12，Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form，Cytotoxic T-Lymphocyte-Associated Serine Esterase-4，CD152 Isoform，CD152 Antigen，CELIAC3，IDDM12，ALPS5，GRD4，GSE，CD，CTLA-4 Antigen
研究＆開発段階	Approved

英語名	Cytotoxic T-Lymphocyte-Associated Antigen 4
ターゲットの別称	Celiac Disease 3，Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4，Cytotoxic T-Lymphocyte Protein 4，CD152，Cytotoxic T-lymphocyte-associated antigen 4，CTLA4，CTLA-4，Cytotoxic T-Lymphocyte Associated Protein 4，Insulin-Dependent Diabetes Mellitus 12，Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form，Cytotoxic T-Lymphocyte-Associated Serine Esterase-4，CD152 Isoform，CD152 Antigen，CELIAC3，IDDM12，ALPS5，GRD4，GSE，CD，CTLA-4 Antigen
市販薬剤の数	5
治験薬の数	64
研究＆開発段階	Approved

CTLA-4 製品リスト

属性
Protein (19)Kits (2)Antibody (1)
製品ライブラリ
オンライン (22)
種
Human (11)Cynomolgus / Rhesus macaque (4)Mouse (5)Rat (2)
タグ
His Tag (6)Fc Tag (4)Strep Tag (1)His Tag & Avi Tag (4)Fc Tag & Avi Tag (3)Mouse IgG Fc Tag (1)- (3)
マーカー
Unconjugated (11)Biotin-labeled (7)- (2)PE Labeled (2)

製品番号	種	発現システム	製品説明
HOT CT4-H5255	Human	HEK293	Human CTLA-4 / CD152 Protein, Fc Tag, low endotoxin (MALS verified)
HOT CT4-H52H9	Human	HEK293	Human CTLA-4 / CD152 Protein, His Tag, active dimer, low endotoxin (MALS verified)
HOT CT4-H82E1	Human	HEK293	Biotinylated Human CTLA-4 Protein, His,Avitag™
HOT CT4-H82E3	Human	HEK293	Biotinylated Human CTLA-4 Protein, His,Avitag™ (MALS verified)
CT4-H5229	Human	HEK293	Human CTLA-4 / CD152 Protein, His Tag
CT4-H5284	Human	HEK293	Human CTLA-4 / CD152 Protein, Twin-Strep Tag
CT4-H52A4	Human	HEK293	Human CTLA-4 / CD152 Protein, mouse IgG2a Fc Tag, low endotoxin (MALS verified)
CT4-H82F3	Human	HEK293	Biotinylated Human CTLA-4 Protein, Fc,Avitag™
CT4-HP2H3	Human	HEK293	PE-Labeled Human CTLA-4 / CD152 Protein, His TagStar Staining
EP-116	Human	-	B7-1 [Biotinylated] : CTLA-4 Inhibitor Screening ELISA Kit

総数量22

CTLA-4バックグランド

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

CTLA-4分子の別称

CTLA4,CD152

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
CS-1002	CS-1002; SHR-8068	Phase 3 Clinical	Cstone Pharmaceuticals	Adenocarcinoma; Bile Duct Neoplasms; Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Esophageal Squamous Cell Carcinoma; Gastroesophageal Junction Neoplasms; Neoplasms; Rectal Neoplasms; Solid tumours; Stomach Neoplasms; Uterine Cervical Neoplasms	詳細
Botensilimab	AGEN-1181	Phase 3 Clinical	Agenus Inc	Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal adenocarcinoma; Esophageal Neoplasms; Fibrolamellar hepatocellular carcinoma; Glioblastoma; Gliosarcoma; Hemangiosarcoma; Liver Neoplasms; Melanoma; Microsatellite Instability; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Solid tumours; Stomach Neoplasms; Uterine Cervical Neoplasms	詳細
Sturlimogene Erparepvec	RP-2	Phase 3 Clinical	Replimune Group Inc	Colorectal Neoplasms; Esophageal adenocarcinoma; Gastroesophageal Junction Neoplasms; Neoplasms; Precancerous Conditions; Stomach Neoplasms; Uveal melanoma	詳細
Gotistobart	ONC-392; BNT316; BNT-316	Phase 3 Clinical	Oncoimmune Inc	Anorectal disorders; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Cystadenocarcinoma, Serous; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gastroesophageal Junction Neoplasms; Head and Neck Neoplasms; Melanoma; Metastatic breast cancer; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Salivary Gland Neoplasms; Sarcoma; Small Cell Lung Carcinoma; Solid tumours; Stomach Neoplasms; Uterine Cervical Neoplasms	詳細
Erfonrilimab	KN-046	Phase 3 Clinical	Jiangsu Alphamab Biopharmaceuticals Co Ltd	Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Colonic Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Gastrointestinal Neoplasms; Lymphoma; Neuroendocrine Tumors; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms; Thymoma; Thymus Neoplasms; Triple Negative Breast Neoplasms	詳細
Volrustomig	MEDI5752; MEDI-5752	Phase 3 Clinical	Medimmune Llc	Bile Duct Neoplasms; Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Head and Neck Neoplasms; Mesothelioma; Papillomavirus Infections; Sarcoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Uterine Cervical Neoplasms	詳細
Ipilimumab biosimilar (Henlius)	HLX13	Phase 3 Clinical		Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Esophageal Neoplasms; Liver Neoplasms; Melanoma; Mesothelioma; Solid tumours	詳細
Nurulimab/Prolgolimab	BCD-217; BCD-145/BCD-100	Phase 3 Clinical	BIOCAD JSC	Melanoma; Skin Melanoma	詳細
Pembrolizumab/Quavonlimab	MK-1308A	Phase 3 Clinical	Merck Sharp & Dohme Corp, Msd Ireland (Carlow), MSD R&D（China）Co Ltd	Carcinoma, Hepatocellular; Carcinoma, Renal Cell; Colorectal Neoplasms; Melanoma; Small Cell Lung Carcinoma; Solid tumours	詳細
Futermestotug	YH-001	Phase 2 Clinical		Alopecia Areata; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Melanoma; Sarcoma; Solid tumours	詳細
Danvilostomig	SI-B003	Phase 2 Clinical	Sichuan Baili Pharmaceutical Co Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Esophageal Neoplasms; Melanoma; Metastatic breast cancer; Nasopharyngeal Carcinoma; Neoplasm Metastasis; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms	詳細
BMS-986288	BMS-986288	Phase 2 Clinical	Cytomx Therapeutics Inc	Neoplasms	詳細
Evalstotug	CAB-CTLA-4; BA-3071	Phase 2 Clinical	BeOne Medicines Ltd, Bioatla	Carcinoma, Non-Small-Cell Lung; Melanoma	詳細
Vudalimab	XmAb-717; XmAb-20717; XmAb 717	Phase 2 Clinical	Xencor Inc	Adenocarcinoma, Clear Cell; Adenoma, Acidophil; Adnexal Diseases; Astrocytoma; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Basal Cell; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Castration-Sensitive Prostate Neoplasms; Cholangiocarcinoma; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gastroesophageal Junction Neoplasms; Hodgkin Disease; Melanoma; Mesothelioma; Nasopharyngeal Carcinoma; Ovarian Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Thymoma; Thyroid Neoplasms; Uterine Cervical Neoplasms; Vulvar Neoplasms	詳細
Recombinant anti-CTLA-4 human monoclonal antibody (Hualan Biological Engineering)		Phase 2 Clinical	Hualan Ankang Biotechnology Co Ltd	Melanoma	詳細
Lorigerlimab	MGD-019; AEX1344	Phase 2 Clinical	Macrogenics Inc	Adenocarcinoma, Clear Cell; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Hormone-Resistant Prostate Neoplasms; Melanoma; Neoplasm Metastasis; Neoplasms; Ovarian Clear Cell Carcinoma; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Skin Melanoma; Solid tumours; Uterine Cervical Neoplasms	詳細
Belatacept biosimilar (Alphamab)	KN-019	Phase 2 Clinical	Suzhou Alphamab Co Ltd	Arthritis, Rheumatoid; Rejection of renal transplantation	詳細
PD-L1/CTLA4 bispecific monoclonal antibody (Changhai Hospital)		Phase 2 Clinical	Changhai Hospital of Navy Medical University	Pancreatic Neoplasms	詳細
Abatacept (Orban Biotech)		Phase 2 Clinical	Orban Biotech, The National Institute Of Diabetes And Digestive And Kidney Diseases	Diabetes Mellitus, Type 1	詳細
Quavonlimab	AK-107; MK-1308	Phase 2 Clinical		Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Melanoma; Neoplasms; Small Cell Lung Carcinoma; Solid tumours	詳細
Zalifrelimab	AGEN-1884; RebmAb-600; UGN-301	Phase 2 Clinical	4-Antibody AG, Ludwig Institute For Cancer Research	Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Hemangiosarcoma; Pancreatic Neoplasms; Prostatic Neoplasms; Sarcoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Urinary Bladder Neoplasms; Urologic Neoplasms; Uterine Cervical Neoplasms	詳細
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute)		Phase 2 Clinical	Shanghai Cell Therapy Research Institute	Neoplasms	詳細
KD-6001	KD-6001	Phase 2 Clinical	Shanghai Celgen Bio-Pharmaceutical Co Ltd, Shanghai Kanda Bio-Technology Co Ltd	Carcinoma, Hepatocellular; Liver Neoplasms; Melanoma; Neoplasms; Solid tumours	詳細
Porustobart	HBM-4003; HCAb 4003-2	Phase 2 Clinical	Harbour Biomed	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Melanoma; Neoplasms; Neuroendocrine Tumors; Solid tumours	詳細
JK-08	JK-08	Phase 2 Clinical	Xinlitai (Chengdu) Biological Technology Co Ltd	Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Esophageal Neoplasms; Melanoma; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Thyroid Neoplasms; Triple Negative Breast Neoplasms	詳細
Sovipostobart	BMS-986249	Phase 2 Clinical	Cytomx Therapeutics Inc	Neoplasms	詳細
GI-101	SIM-323; SIM323; SIM0323; GI-101	Phase 2 Clinical	GI Innovation Inc	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Neoplasms; Solid tumours; Uterine Cervical Neoplasms	詳細
Apalulizumab		Phase 2 Clinical	Shanghai Rui Jin Hospital	Pancreatic Neoplasms	詳細
Firastotug	ADG-116	Phase 2 Clinical	Adagene (Suzhou) Ltd	Solid tumours	詳細
LM-168	LM-168	Phase 2 Clinical	LaNova Medicines Ltd	Solid tumours	詳細
HX-044	HX044; HX-044	Phase 2 Clinical	Hanx Biopharmaceuticals Pty Ltd	Lymphoma; Solid tumours	詳細
EGL-001	EGL-001	Phase 2 Clinical	Egle Therapeutics	Neoplasms; Solid tumours	詳細
CS-2009	CS-2009	Phase 2 Clinical	Cstone Pharmaceuticals	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Ovarian Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Triple Negative Breast Neoplasms	詳細
COYA-302	COYA 302; COYA-302; COYA302	Phase 2 Clinical	Coya Therapeutics Inc	Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; Parkinson Disease	詳細
HC-010(Shanghai Hongcheng)	HC-010; HC010	Phase 2 Clinical	Shanghai Hongcheng Pharmaceutical Co Ltd	Carcinoma, Non-Small-Cell Lung; Solid tumours	詳細
Efzilonkofusp alfa	GI-102	Phase 2 Clinical	GI Innovation Inc	Astrocytoma; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Renal Cell; Colorectal Neoplasms; Glioblastoma; Gliosarcoma; Liver Neoplasms; Melanoma; Ovarian Neoplasms; Skin Melanoma; Soft Tissue Neoplasms; Solid tumours	詳細
SV-102	SV-102; SV102; SYNC-T SV-102	Phase 2 Clinical	Syncromune Inc	Prostatic Neoplasms, Castration-Resistant	詳細
Anti-CTLA-4/PD-1 expressing EGFR-CAR-T		Phase 2 Clinical	Shanghai Cell Therapy Research Institute	Solid tumours	詳細
IMM-27M	IMM-27M; IMM27M; SYN27M; SYN-27M	Phase 2 Clinical		Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Neoplasms; Pathologic Processes; Solid tumours	詳細
Vilastobart	XTX-101; XTX101	Phase 2 Clinical	Xilio Development Inc	Colorectal Neoplasms	詳細
RP-3	RP-3	Phase 2 Clinical	Replimune Inc	Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Colorectal Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck	詳細
Muzastotug	ADG-126	Phase 2 Clinical	Adagene Inc	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Liver Neoplasms; Solid tumours	詳細
PD-L1 antibody combined with CTLA-4 antibody (Shanghai Zhongshan Hospital)		Phase 2 Clinical	Shanghai Zhongshan Hospital	Cholangiocarcinoma	詳細
JS-007	JS007; JS-007	Phase 2 Clinical	Shanghai Junshi Biosciences Co Ltd	Carcinoma, Hepatocellular; Lung Neoplasms; Melanoma; Neoplasms; Pancreatic Neoplasms; Solid tumours	詳細
KN-044	KN-044	Phase 1 Clinical	Suzhou Alphamab Co Ltd	Small Cell Lung Carcinoma; Solid tumours	詳細
Bavunalimab	XmAb-22841; XmAb-841	Phase 1 Clinical	Xencor Inc	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gastroesophageal Junction Neoplasms; Melanoma; Nasopharyngeal Carcinoma; Pancreatic Neoplasms; Penile Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms	詳細
Anti-CTLA-4 monoclonal antibody (Regeneron)	REGN-4659	Phase 1 Clinical	Regeneron Pharmaceuticals Inc	Carcinoma, Non-Small-Cell Lung	詳細
BMS-986218 (Bristol-Myers Squibb)	BMS-986218	Phase 1 Clinical	Bristol-Myers Squibb Company	Adrenal Gland Neoplasms; Liver Neoplasms; Lung Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours	詳細
Ipilimumab biosimilar (Mab-Venture/ShuangLu Pharmaceutical)	MV-049	Phase 1 Clinical	Beijing Sl Pharmaceutical Co Ltd, Mab-Venture Biopharm Co Ltd	Solid tumours	詳細
SAL-008	SAL-008	Phase 1 Clinical	Xinlitai (Chengdu) Biological Technology Co Ltd	Neoplasms	詳細
GIGA-564	GIGA-564	Phase 1 Clinical	GigaGen Inc	Solid tumours	詳細
CTLA-4 Mab (Beijng Immunoah Pharma Tech)	5E3 (Beijng Immunoah Pharma Tech); CTLA-4 Mab (Beijng Immunoah Pharma Tech)	Phase 1 Clinical	Beijng Immunoah Pharma Tech Co Ltd	Solid tumours	詳細
GB-268	GB268	Phase 1 Clinical	Genor Biopharma Co Ltd	Neoplasms; Solid tumours	詳細
A-337 (Klus Pharma)	A337 (Klus Pharma); A-337 (Klus Pharma)	Phase 1 Clinical	Klus Pharma Inc	Neoplasms	詳細
BZE-2209	BZE-2209; BZE2209; αPD1/CTLA4-MSLN-CAR T Cells	Phase 1 Clinical	Shanghai Cell Therapy Group Co Ltd	Solid tumours	詳細
GK-201	GK201; GK-201	Phase 1 Clinical	Suzhou Guokuang Pharmaceutical Tech Co Ltd	Solid tumours	詳細
STW204/Gotistobart	AI-061	Phase 1 Clinical	Oncoc4 Inc	Anus Neoplasms; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Cystadenocarcinoma, Serous; Endometrial Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gastroesophageal Junction Neoplasms; Melanoma; Ovarian Neoplasms; Peritoneal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	詳細
KM602	KM602; KM-602; XZP-KM602	Phase 1 Clinical	Xuanzhu (Shijiazhuang) Biotechnology Co Ltd	Solid tumours	詳細
IMD-303	IMD-303; IMD303	Phase 1 Clinical	Shanghai Affinity Biopharmaceutical Co Ltd	Solid tumours	詳細
Imiquimod/Zalifrelimab	UGN-302; UGN-201+UGN-301	Phase 1 Clinical	Urogen Pharma	Urinary Bladder Neoplasms	詳細
TWP-102	TWP-102	Phase 1 Clinical	Therawisdom Biopharma Co Ltd	Neoplasms	詳細
SKB-337	SKB337; A-337; SKB-337	Phase 1 Clinical	Sichuan Kelun-Biotech Biopharmaceutical Co Ltd	Solid tumours	詳細
BAT-4706	BAT-4706	Phase 1 Clinical	Bio-Thera Solutions Ltd	Melanoma; Solid tumours	詳細
B7-2/GM-CSF cancer gene therapy	CIT	Phase 1 Clinical	Radient	Neoplasms	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Cadonilimab	AK-104; AK104	Approved		开坦尼	Mainland China	Uterine Cervical Neoplasms	Kangfang Pharmaceutical Co Ltd	2022-06-29	Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Gastroesophageal Junction Neoplasms; Lung Neoplasms; Lymphoma, T-Cell, Peripheral; Melanoma; Mesothelioma; Microsatellite Instability; Microsatellite instability-high cancer; Mismatch Repair Deficient Cancer; Nasopharyngeal Carcinoma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Diseases; Small Cell Lung Carcinoma; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urologic Neoplasms; Uterine Cervical Neoplasms; Vaginal Neoplasms; Vulvar Neoplasms	詳細
Ipilimumab	10D1; MDX-CTLA-4; Anti-CTLA-4 Mab; BMS-734016; Mab-10D14; MDX-101; MDX-010	Approved	Bristol-Myers Squibb Company	Yervoy, 逸沃	United States	Melanoma	Bristol-Myers Squibb Company	2011-03-25	Adenocarcinoma; Adenocarcinoma of Lung; Adenocarcinoma, Mucinous; Adrenocortical Carcinoma; Angioimmunoblastic T-cell Lymphoma; Anus Neoplasms; Brain metastases; Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Acinar Cell; Carcinoma, Adenoid Cystic; Carcinoma, Basal Cell; Carcinoma, Embryonal; Carcinoma, Endometrioid; Carcinoma, Giant Cell; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Carcinoma, Verrucous; Cholangiocarcinoma; Chordoma; Choriocarcinoma; Colonic Neoplasms; Colorectal Neoplasms; Cystadenocarcinoma; Cystadenocarcinoma, Mucinous; Cystadenocarcinoma, Serous; Endodermal Sinus Tumor; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Fallopian Tube Neoplasms; Fibromatosis, Aggressive; Gallbladder Neoplasms; Gastrointestinal Stromal Tumors; Gestational Trophoblastic Disease; Glioblastoma; Gliosarcoma; Hemangiosarcoma; HIV I	詳細
IpilimumabN01 (Innovent Biologics)	IBI-310	Approved	Innovent Biologics(Suzhou) Co Ltd	达伯欣	Mainland China	Colonic Neoplasms	Innovent Biologics Inc	2025-12-22	Bile Duct Neoplasms; Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Liver Neoplasms; Melanoma; Microsatellite Instability; Mismatch Repair Deficient Cancer; Nasopharyngeal Carcinoma; Solid tumours; Stomach Neoplasms; Uterine Cervical Neoplasms	詳細
Tremelimumab	CP-675206; CP-675	Approved	Pfizer Inc	IMJUDO	United States	Carcinoma, Hepatocellular	Astrazeneca Ab	2022-10-21	Adenocarcinoma; Bile Duct Neoplasms; Biliary Tract Neoplasms; Bone metastases; Breast Neoplasms; Carcinoma; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Colorectal Neoplasms; Cystadenoma, Serous; Digestive System Diseases; Dysgerminoma; Endometrial Neoplasms; Esophageal adenocarcinoma; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Gastroesophageal Junction Neoplasms; Genital Neoplasms, Female; Glioblastoma; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Hepatitis C, Chronic; HIV Infections; Hydronephrosis; Kidney Neoplasms; Klatskin Tumor; Laryngeal Diseases; Liver Neoplasms; Lung Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell, Cutaneous; Melanoma; Mesothelioma; Metastatic breast cancer; Microsatel	詳細
Iparomlimab/Tuvonralimab	PBS-103/PBS-105; QL-1706; PSB-205	Approved	Qilu Pharmaceutical Co Ltd	齐倍安	Mainland China	Uterine Cervical Neoplasms	Qilu Pharmaceutical Co Ltd	2024-09-26	Adenocarcinoma of Lung; Biliary Tract Neoplasms; Bone Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Cholangiocarcinoma; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Fallopian Tube Diseases; Head and Neck Neoplasms; Liver Neoplasms; Lung Neoplasms; Melanoma; Microsatellite instability-high cancer; Mismatch Repair Deficient Cancer; Nasopharyngeal Carcinoma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Rectal Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Intraepithelial Lesions of the Cervix; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms	詳細

レビュー

J***o2023-02-03
1評価
Human CTLA-4 / CD152 Protein, His Tag
Bought as potential coating protein to be used in ELISA to detected expressed Anti-CTLA-4. Vials arrived promptly and very well packaged. The website is informative and very intuitive to navigate to be able to find the product best suited for your needs. MSDS, CofA and Dataheets are readily available and contain accurate and comprehensive information e.g. storage temperatures, glycosylation information and purity- the guidance for usage of the protein was especially useful to serve as a jumping off point for coating concentrations. Results so far have been very promising which is what I have come to expect from ACROBiosystems- great work!
J***r2022-01-11
0評価
Human CTLA-4 / CD152 Protein, His Tag
The product came in packaged properly and with proper documentation. CoAs were clear as to when the product would expire, both in the lyophilized state and reconstituted. Instructions for reconstitution were also clear. The packaging made it easy to quickly transfer the product to the appropriate storage. Package was shipped in a reasonable timeline. Details for the product were easy to find, which was extremely helpful for entering into our system.