CX3CL1

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CX3CL1 Overview

Molecule Name

C-X3-C motif chemokine ligand 1

Synonyms

CX3CL1,Fractalkine

Drug Development Progress

Drugs in Clinical Trials1

Approved Drugs0

Highest Development StagePhase 2 Clinical

Target Synonym

Small Inducible Cytokine Subfamily D (Cys-X3-Cys)， Member 1 (Fractalkine， Neurotactin)，Small Inducible Cytokine Subfamily D (Cys-X3-Cys)， Member-1，CX3CL1，Small-inducible cytokine D1，FKN，Fractalkine，A-152E5.2，C-X3-C Motif Chemokine Ligand 1，Chemokine (C-X3-C Motif) Ligand 1，CX3C Membrane-Anchored Chemokine，C-X3-C Motif Chemokine 1，Neurotactin，SCYD1，NTT，C3Xkine，ABCD-3，CXC3C，CXC3，NTN，Chemokine CX3CL1

Background

Fractalkine is also known as C-X3-C motif chemokine 1 (CX3CL1) and neurotactin. Fractalkine is a large cytokine protein of 373 amino acids, it contains multiple domains and is the only known member of the CX3C chemokine family. Fractalkine is found commonly throughout the brain, particularly in neural cells, and its receptor is known to be present on microglial cells. It has also been found to be essential for microglial cell migration. CX3CL1 is also up-regulated in the hippocampus during a brief temporal window following spatial learning, the purpose of which may be to regulate glutamate-mediated neurotransmission tone. This indicates a possible role for the chemokine in the protective plasticity process of synaptic scaling.