言語を選択

CXADR

CXADR 詳細

英語名	Calcium sensing receptor	市販薬剤の数	6
治験薬の数	5	ターゲットの別称	Parathyroid cell calcium-sensing receptor 1，FHH，FIH，HHC，Receptors， Calcium-Sensing，Extracellular calcium-sensing receptor，hCasR，GPRC2A，Calcium Sensing Receptor，Parathyroid Ca(2+)-Sensing Receptor 1，Severe Neonatal Hyperparathyroidism，Calcium-Sensing Receptor，HYPOC1，NSHPT，PCaR1，EIG8，HHC1，CaSR，CAR，Hypocalciuric Hypercalcemia 1
研究＆開発段階	Approved

英語名	Calcium sensing receptor
ターゲットの別称	Parathyroid cell calcium-sensing receptor 1，FHH，FIH，HHC，Receptors， Calcium-Sensing，Extracellular calcium-sensing receptor，hCasR，GPRC2A，Calcium Sensing Receptor，Parathyroid Ca(2+)-Sensing Receptor 1，Severe Neonatal Hyperparathyroidism，Calcium-Sensing Receptor，HYPOC1，NSHPT，PCaR1，EIG8，HHC1，CaSR，CAR，Hypocalciuric Hypercalcemia 1
市販薬剤の数	6
治験薬の数	5
研究＆開発段階	Approved

CXADR 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
His Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
CXR-H5222	Human	HEK293	Human CXADR / CAR Protein, His Tag

総数量1

CXADRバックグランド

Coxsackie virus and adenovirus receptor (CXADR) is also known as CAR, is a type I transmembrane glycoprotein for group B coxsackie viruses and subgroup C adenoviruses, and belongs to the CTX family of the Ig superfamily. CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins such as: fibronectin, agrin, laminin-1 and tenascin-R. Human CXADR protein contains a signal sequence, a extracellular domain (ECD) with a V type (D1) and a C2 type (D2) Iglike domain, a transmembrane segment and a intracellular domain. D1 is thought to be responsible for homodimer formation in trans within tight junctions, and is necessary and sufficient for adenovirus binding. Variants of CXADR are attached to the cell membrane by a GPI- anchor.

CXADR分子の別称

CXADR,CAR,CAR4,6,HCAR

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Encaleret sulfate	MK-5442; JTT-305; BBP-305; CLTX-305	Phase 3 Clinical	Japan Tobacco (Hong Kong) Ltd	Osteoporosis; Hypocalcemia; Osteoporosis, Postmenopausal; Hypoparathyroidism	詳細
SHR-6508	SHR-6508	Phase 3 Clinical	Shanghai Hengrui Pharmaceutical Co Ltd	Hyperparathyroidism, Secondary; Kidney Diseases; Renal Insufficiency, Chronic; Hyperparathyroidism	詳細
LNP-1892	LNP-1892	Phase 2 Clinical	Lupin Ltd	Hyperparathyroidism	詳細
DS-9194b	DS-9194b	Phase 1 Clinical	Daiichi Sankyo Co Ltd	Osteoporosis	詳細
RT-102(Rani)	RT-102	Phase 1 Clinical	Rani Therapeutics Holdings Inc	Osteoporosis	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Upacicalcet	SK-1403; AJT-240	Approved	Ajinomoto Co Inc	ウパシタ, Upasita	Japan	Hyperparathyroidism, Secondary	Sanwa Kagaku Kenkyusho Co Ltd	2021-06-23	Hyperparathyroidism, Secondary	詳細
Parathyroid hormone (Shire)	SHP-634; ALX-111; 423562; NPSP-795; rhPTH (1-84); SHP-635; rhPTH-1-84; PTH (1-84); SB-423562; PTH 1-84; NPSP-558	Approved	Shire	Natpara, Preotact, Natpar	United States	Hypoparathyroidism	Nps Pharmaceuticals, Inc	2006-04-24	Osteoporosis; Bone Diseases, Endocrine; Osteoporosis, Postmenopausal; Hypocalcemia; Hypoparathyroidism; Hyperparathyroidism; Plaque psoriasis	詳細
Cinacalcet Hydrochloride	AMG-073.HCl; NPS-1493; AMG-073; KRN-1493	Approved	Amgen Inc	Parareg, Sensipar, Mimpara, Regpara, 盖平, Sensipar/Mimpara	United States	Hypercalcemia; Hyperparathyroidism, Secondary	Amgen Inc	2004-03-08	Hyperparathyroidism, Secondary; Rejection of renal transplantation; Hypophosphatemia; Edema, Cardiac; Nephrosis; Renal Insufficiency; Parathyroid Neoplasms; Hypercalcemia; Kidney Diseases; Hyperparathyroidism, Primary; Prostatic Neoplasms; Osteomalacia; Renal Insufficiency, Chronic; Kidney Failure, Chronic; Hyperparathyroidism; Chronic Kidney Disease-Mineral and Bone Disorder	詳細
Etelcalcetide Hydrochloride	ONO-5163; KAI-4169; AMG-416; KAI-4169-HCl	Approved	Amgen Inc	Parsabiv	EU	Hyperparathyroidism, Secondary	Amgen Europe Bv	2016-11-11	Hyperparathyroidism, Secondary; Edema, Cardiac; Renal Insufficiency, Chronic; Kidney Failure, Chronic	詳細
Strontium Ranelate	S-12911; S-12911-2; FK-481	Approved	Laboratoires Servier	Osseor, Protos, Protelos, 欧思美	Mainland China	Osteoporosis, Postmenopausal	Les Laboratoires Servier	2004-09-20	Osteoporosis, Postmenopausal	詳細
Evocalcet	KHK-7580; MT-4580	Approved	Mitsubishi Tanabe Pharma Corp	Orkedia	Japan	Hyperparathyroidism, Secondary	Kyowa Hakko Kirin Co Ltd	2018-03-23	Hyperparathyroidism, Secondary; Parathyroid Neoplasms; Hyperparathyroidism, Primary; Hyperparathyroidism	詳細