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CXCR3

CXCR3 詳細

英語名	C-X-C motif chemokine receptor 3	市販薬剤の数	0
治験薬の数	2	ターゲットの別称	CKR-L2，G protein-coupled receptor 9，IP-10 receptor，CXCR-3，CXC-R3，CXCR3，C-X-C Motif Chemokine Receptor 3，Interferon-Inducible Protein 10 Receptor，GPR9，C-X-C Chemokine Receptor Type 3，Chemokine Receptor 3，CD183 Antigen，CMKAR3，Chemokine (C-X-C Motif) Receptor 3，Mig Receptor，IP10-R，CD182，CD183，Mig-R，MigR，Receptors， CXCR3
研究＆開発段階	Phase 1 Clinical

英語名	C-X-C motif chemokine receptor 3
ターゲットの別称	CKR-L2，G protein-coupled receptor 9，IP-10 receptor，CXCR-3，CXC-R3，CXCR3，C-X-C Motif Chemokine Receptor 3，Interferon-Inducible Protein 10 Receptor，GPR9，C-X-C Chemokine Receptor Type 3，Chemokine Receptor 3，CD183 Antigen，CMKAR3，Chemokine (C-X-C Motif) Receptor 3，Mig Receptor，IP10-R，CD182，CD183，Mig-R，MigR，Receptors， CXCR3
市販薬剤の数	0
治験薬の数	2
研究＆開発段階	Phase 1 Clinical

CXCR3 製品リスト

属性
Protein (4)Cell (2)
製品ライブラリ
オンライン (6)
種
Human (5)Mouse (1)
タグ
- (5)His Tag & Flag Tag (1)
マーカー
Unconjugated (3)- (2)Biotin-labeled (1)

製品番号	種	発現システム	製品説明
HOT CX3-H52D5	Human	HEK293	Human CXCR3 Protein, Flag,His Tag (Detergent)
CCHO-ATP252	Human	CHO	CHO/Human CXCR3 Stable Cell Line
CHEK-ATP253	Human	HEK293	HEK293/Human CXCR3 Stable Cell Line
CX3-H52P4	Human	HEK293	Human CXCR3 Full Length Protein (VLP)
CX3-H82P3	Human	HEK293	Biotinylated Human CXCR3 Full Length Protein (VLP)
CX3-M52P7	Mouse	HEK293	Mouse CXCR3 Full Length Protein (VLP)

総数量6

CXCR3バックグランド

Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells, and cause tissue extravasation. Given these properties, their role in anti-tumor immune response in the cancer environment is of great interest. Although immunotherapy has shown clinical benefit for some cancer patients, other patients do not respond. One of the mechanisms of resistance to checkpoint inhibitors may be chemokine signaling. The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis). However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis). Thus, a better understanding of CXCL9, -10, -11/CXCR3 axis is necessary to develop effective cancer control.

CXCR3分子の別称

CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
OCU-110	OCU-10-C-110; OGX-110; OCU-110	Phase 1 Clinical	Ocugenix Corp	Macular Degeneration	詳細
ACT-777991	ACT-777991	Phase 1 Clinical	Idorsia Pharmaceuticals Ltd	Diabetes Mellitus, Type 1; Inflammation	詳細