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Dkk-1

Dkk-1 詳細

英語名	Dickkopf-related protein 1	市販薬剤の数	0
治験薬の数	4	ターゲットの別称	Dickkopf-Like Protein 1，Dickkopf 1 Homolog，Dickkopf-1 Like，Dickkopf-1，Dkk-1，UNQ492/PRO1008，Dickkopf-related protein 1，hDkk-1，SK，DKK1，Dickkopf WNT Signaling Pathway Inhibitor 1，Dickkopf 1 Homolog (Xenopus Laevis)，Dickkopf (Xenopus Laevis) Homolog 1
研究＆開発段階	Phase 2 Clinical

英語名	Dickkopf-related protein 1
ターゲットの別称	Dickkopf-Like Protein 1，Dickkopf 1 Homolog，Dickkopf-1 Like，Dickkopf-1，Dkk-1，UNQ492/PRO1008，Dickkopf-related protein 1，hDkk-1，SK，DKK1，Dickkopf WNT Signaling Pathway Inhibitor 1，Dickkopf 1 Homolog (Xenopus Laevis)，Dickkopf (Xenopus Laevis) Homolog 1
市販薬剤の数	0
治験薬の数	4
研究＆開発段階	Phase 2 Clinical

Dkk-1 製品リスト

属性
Protein (4)
製品ライブラリ
オンライン (4)
種
Human (3)Mouse (1)
タグ
His Tag (2)Fc Tag (1)Fc Tag & Avi Tag (1)
マーカー
Unconjugated (3)Biotin-labeled (1)

製品番号	種	発現システム	製品説明
DK1-H5221	Human	HEK293	Human Dkk-1 Protein, His Tag, premium grade
DK1-H5258	Human	HEK293	Human Dkk-1 Protein, Fc Tag (MALS verified)
DK1-H82F5	Human	HEK293	Biotinylated Human Dkk-1 Protein, Fc,Avitag™
DK1-M52H6	Mouse	HEK293	Mouse Dkk-1 Protein, His Tag

総数量4

Dkk-1バックグランド

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

Dkk-1分子の別称

DKK1,SK

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
JS-015	JS-015	Phase 2 Clinical	Shanghai Junshi Biological Engineering Co Ltd	Colorectal Neoplasms; Neoplasms; Solid tumours	詳細
AGA-2115	AGA2115; AGA-2115	Phase 2 Clinical	Angitia Biopharmaceuticals (Guangzhou) Ltd	Osteogenesis Imperfecta	詳細
AGA-2118	AGA-2118	Phase 2 Clinical	Angitia Biomedicines Ltd	Osteoporosis; Osteoporosis, Postmenopausal	詳細
Sirexatamab	DKN-01; LY-2812176	Phase 2 Clinical	Eli Lilly And Company	Bile Duct Neoplasms; Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carcinosarcoma; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Gallbladder Neoplasms; Liver Neoplasms; Multiple Myeloma; Ovarian Neoplasms; Prostatic Neoplasms; Solid tumours; Stomach Neoplasms; Uterine Neoplasms	詳細