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Dkk-3

Dkk-3 Overview

English Name	Dickkopf-related protein 3	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	Dickkopf 3 Homolog (Xenopus Laevis)，UNQ258/PRO295，Dickkopf-3，Dickkopf-related protein 3，hDkk-3，REIC，DKK3，Dickkopf WNT Signaling Pathway Inhibitor 3，Regulated In Glioma，Dkk-3，Dickkopf (Xenopus Laevis) Homolog 3，Dickkopf 3 Homolog，Dickkopf Homolog 3，RIG-Like 5-6，RIG-Like 7-1，RIG
Highest Development Stage	Phase 2 Clinical

English Name	Dickkopf-related protein 3
Target Synonym	Dickkopf 3 Homolog (Xenopus Laevis)，UNQ258/PRO295，Dickkopf-3，Dickkopf-related protein 3，hDkk-3，REIC，DKK3，Dickkopf WNT Signaling Pathway Inhibitor 3，Regulated In Glioma，Dkk-3，Dickkopf (Xenopus Laevis) Homolog 3，Dickkopf 3 Homolog，Dickkopf Homolog 3，RIG-Like 5-6，RIG-Like 7-1，RIG
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 2 Clinical

Dkk-3 Product List

Product Category
Protein (2)
Product Status
Launched (2)
Species
Human (1)Mouse (1)
Tag
His Tag (2)
Conjugate
Unconjugated (2)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
DK3-H5220	Human	HEK293	Human Dkk-3 (R335G) Protein, His Tag
DK3-M5226	Mouse	HEK293	Mouse Dkk-3 Protein, His Tag

Total: 2

Dkk-3 Background

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.