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DR3

DR3 製品リスト

属性
Protein (7)Cell (1)
製品ライブラリ
オンライン (8)
種
Cynomolgus (2)Human (5)Mouse (1)
タグ
Fc Tag (2)His Tag (3)- (1)Fc Tag & Avi Tag (1)His Tag & Avi Tag (1)
マーカー
Unconjugated (5)- (1)Biotin-labeled (2)

製品番号	種	発現システム	製品説明
HOT DR3-H5253	Human	HEK293	Human DR3 Protein, Fc Tag, low endotoxin (MALS verified)
HOT DR3-H82E3	Human	HEK293	Biotinylated Human DR3 / TNFRSF25 Protein, His,Avitag™ (MALS verified)
HOT TN5-H52H3	Human	HEK293	Human DR3 / TNFRSF25 Protein, His Tag, low endotoxin (Mass Spec & MALS verified)
DR3-H82F3	Human	HEK293	Biotinylated Human DR3 / TNFRSF25 Protein, Fc,Avitag™ (MALS verified)
SCJUR-STF178	Human	Jurkat	Human DR3 (TL1A receptor) (Luc) Jurkat Reporter Cell
DR3-M52H3	Mouse	HEK293	Mouse DR3 / TNFRSF25 Protein, His Tag, low endotoxin (HPLC & SPR verified)
DR3-C52H3	Cynomolgus	HEK293	Cynomolgus DR3 / TNFRSF25 Protein, His Tag, low endotoxin (SPR verified)
TN5-C5257	Cynomolgus	HEK293	Cynomolgus DR3 / TNFRSF25 Protein, Fc Tag, low endotoxin

総数量8

お問い合わせ

DR3バックグランド

Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) is also known as Apo-3, Death receptor 3 (DDR3 or DR3), Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor TRAMP, Lymphocyte-associated receptor of death, Apo-3, which is a member of the TNF-receptor superfamily. TNFRSF25 is a homodimer protein, which can Interact strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. TNFRSF25 is receptor for TNFSF12 / APO3L / TWEAK.

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Ontamalimab	SHP-647; PF-00547659; PF-547659	Phase 3 Clinical	Pfizer Inc	Ileitis; Colitis, Ulcerative; Crohn Disease	詳細
Vedolizumab biosimilar (Polpharma Biologics)	PB-016	Phase 3 Clinical	Polpharma Biologics Sa	Pouchitis; Colitis, Ulcerative; Crohn Disease	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Vedolizumab	MLN-0002; LPD-02; MLN-002; MLN-02; LDP-02	Approved	Millennium Pharmaceuticals Inc	安吉优, Entyvio	United States	Colitis, Ulcerative; Crohn Disease	Takeda Pharmaceuticals USA Inc	2014-05-20	Celiac Disease; Carcinoma, Non-Small-Cell Lung; Melanoma; Crohn Disease; Gastritis; Urogenital Neoplasms; Colitis, Ulcerative; Cholangitis, Sclerosing; Pediatric ulcerative colitis; Solid tumours; Colitis; Pouchitis; Neoplasms; Pediatric Crohn's disease; Inflammatory Bowel Diseases; HIV Infections; Hematopoietic stem cell transplantation (HSCT)	詳細