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DXD

DXD 製品リスト

属性
Antibody (3)
製品ライブラリ
オンライン (3)
種
Mouse (3)
タグ
- (3)
マーカー
Unconjugated (1)HRP Labeled (1)Biotin-labeled (1)

製品番号	種	発現システム	製品説明
HOT DXD-M684	Mouse	HEK293	Monoclonal Anti-DXD&Exatecan Antibody, Mouse IgG1
DXD-BVM807	Mouse	HEK293	Biotinylated Anti-DXD&Exatecan Antibody, Mouse IgG1, Avitag™
DXD-PLM684	Mouse	HEK293	HRP conjugated Monoclonal Anti-DXD&Exatecan Antibody, Mouse IgG1

総数量3

DXDバックグランド

Dxd (Exatecan ADC derivative) is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 uM for targeting ADCs (DS-8201A). Dxd was cytotoxic to human tumor cell lines KPL-4, NCI-N87 and SK-BR, 3 and the IC50s of MDA-MB-468 was 1.43 NM-4.07 nM, while lgGADC (Dxd as payload) had no inhibitory effect on HER2 expression in the 4 cell lines. DS8201a (Dxd as payload) had a significant inhibitory effect on HER2-positive KPL-4 and NCI cell lines N87 and SK-BRwith IC50 values of 26.8, 25.4 and 6.7 ng/mL, respectively, but had no inhibitory effect on MDA MB-468 (IC50, > 10000 - mL). HRP-anti-DXD-antibody is a conjugation product of HRP and anti-DXD-antibody. It can be used in PK, PD analysis and ELISA.

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Tifcemalimab	TAB-004; JS-004	Phase 3 Clinical	Shanghai Junshi Biosciences Co Ltd	Solid tumours; Head and Neck Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Hodgkin Disease; Nasopharyngeal Carcinoma; Lymphoma; Lung Neoplasms; Melanoma; Neoplasm Metastasis	詳細
ANB-032	ANB-032	Phase 2 Clinical	Anaptysbio Inc	Inflammation; Dermatitis, Atopic; Eczema	詳細
Venanprubart	LY-3361237	Phase 2 Clinical	Sanford-Burnham Medical Research Institute, Eli Lilly And Company	Sjogren's Syndrome; Lupus Erythematosus, Systemic; Psoriasis	詳細
MB-272	MB272; GS-0272	Phase 1 Clinical	University Of Oxford	Arthritis, Rheumatoid; Autoimmune Diseases; Lupus Erythematosus, Systemic	詳細
HFB-200603	HFB-200603	Phase 1 Clinical	HiFiBiO Therapeutics	Carcinoma, Renal Cell; Stomach Neoplasms; Neoplasms; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung	詳細