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EDNRA

EDNRA

EDNRA 詳細

Molecule Name
Endothelin receptor type A
分子の別称
endothelin receptor type A, ETA,ET-A,ETAR,ETRA,MFDA,ETA-R,hET-AR
Drug Development Progress
治験薬の数11
市販薬剤の数8
研究＆開発段階Approved
ターゲットの別称
Endothelin Receptor Type A，EDNRA，ETA-R，Endothelin-1 receptor，hET-AR，ETRA，ET-A，ETA，Endothelin-1-Specific Receptor，Endothelin Receptor Subtype A，G Protein-Coupled Receptor，ETAR，MFDA，Receptor， Endothelin A
バックグランド
EDNRA encodes the endothelin type A receptor, a G protein-coupled receptor mediating vasoconstriction and cell proliferation upon endothelin-1 binding. Overexpression contributes to pulmonary arterial hypertension, cardiovascular disorders, and cancer progression. Selective EDNRA antagonists offer therapeutic potential for managing hypertension, fibrosis, and tumor angiogenesis.

EDNRA 製品リスト

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治験薬に関する情報

英語名研究コード研究開発ステージ会社適応症臨床試験
SC-0062SC-0062; WX-013Phase 3 ClinicalShijiazhuang Zhikang Hongren New Drug Development Co Ltd
Altitude Sickness; Diabetic Nephropathies; Glomerulonephritis, IGA; Kidney Diseases; Pulmonary Arterial Hypertension
詳細
Zibotentan/DapagliflozinPhase 3 ClinicalAstrazeneca Ab, AstraZeneca global R & D (China) Co Ltd
Albuminuria; Kidney Diseases; Renal Insufficiency, Chronic
詳細
PatecibartGMA-301; GMA-301-A; GMA-301-BPhase 2 ClinicalGmax Biopharm Llc
Pulmonary Arterial Hypertension
詳細
ZibotentanZD-4054; AZD-4054Phase 2 ClinicalAstrazeneca Plc
Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Hepatic Insufficiency; Hypertension, Portal; Intermittent Claudication; Liver Cirrhosis; Lung Neoplasms; Metastatic breast cancer; Microvascular Angina; Neoplasm Metastasis; Ovarian Neoplasms; Peripheral Arterial Disease; Prostatic Neoplasms; Renal Insufficiency; Renal Insufficiency, Chronic; Scleroderma, Limited; Scleroderma, Systemic; Solid tumours
詳細
SAL-0120SAL-0120; SAL0120Phase 2 ClinicalShenzhen Salubris Pharmaceuticals Co Ltd
Essential Hypertension; Glomerulonephritis, IGA; Hypertension; Renal Insufficiency, Chronic
詳細
HS-10390HS-10390; HS10390Phase 2 ClinicalChangzhou Hengbang Pharmaceutical Co Ltd, Shanghai Hansoh Biomedical Co Ltd
Glomerulonephritis, IGA; Glomerulosclerosis, Focal Segmental; Renal Insufficiency, Chronic
詳細
BQ-123CGS-26343; BQ-123; PMZ-2123Phase 1 ClinicalMidwestern University
Cardiovascular Diseases; Coronary Artery Disease; Diabetic Ketoacidosis; Heart Failure; Hypertension; Hypertension, Pulmonary; Hypoxia, Brain; Metabolic Syndrome; Multiple System Atrophy; Pain; Proteinuria; Pure Autonomic Failure; Renal Insufficiency, Chronic; ST Elevation Myocardial Infarction
詳細
GMA-131GMA-131Phase 1 ClinicalGmax Biopharm Llc, Gmaxx Biologics Ltd
Diabetic Nephropathies
詳細
AK-1960AK1960; AK-1960Phase 1 Clinical
Renal Insufficiency, Chronic
詳細
GLX-002GLX-002; GLX002Phase 1 ClinicalYabao Pharmaceutical Co Ltd Beijing
Pulmonary Arterial Hypertension
詳細
Bosentan Orally Disintegrating Tablets(Beijing Sunho Pharma)Phase 1 ClinicalBeijing Sunho Pharmaceutical Co Ltd
Pulmonary Arterial Hypertension
詳細

市販薬剤に関する情報

英語名研究コード研究開発ステージ会社オリジナル製品名最初に承認をした国最初の適応症最初に承認を受けた会社承認された日付適応症臨床試験
Clazosentan SodiumRo-61-1790; ACT-108475; AXV-034; VML-588; AXV-034343ApprovedF. Hoffmann-La Roche LtdPivlazJapanSubarachnoid Hemorrhage; Brain Ischemia; Vasospasm, Intracranial; Cerebral InfarctionIdorsia Pharmaceuticals Ltd2022-01-20
Aneurysm; Brain Ischemia; Cerebral Infarction; Subarachnoid Hemorrhage; Vasospasm, Intracranial
詳細
Macitentan/TadalafilApprovedActelion Pharmaceuticals LtdOPSYNVI, YuvanciUnited StatesPulmonary Arterial HypertensionActelion Pharmaceuticals Us Inc2024-03-22
Phenylketonurias; Pulmonary Arterial Hypertension
詳細
AmbrisentanLU-208075; BSF-208075; GSK-132576AApprovedAbbott LaboratoriesLetairis, Volibris, 凡瑞克United StatesPulmonary Arterial HypertensionGilead Sciences Inc2007-06-15
Acute Kidney Injury; Anemia, Sickle Cell; Ascites; Coronavirus Disease 2019 (COVID-19); Hepatorenal Syndrome; Hypertension; Hypertension, Portal; Hypertension, Pulmonary; Hypoxia; Idiopathic Pulmonary Fibrosis; Liver Cirrhosis; Pulmonary Arterial Hypertension; Sarcoidosis; Scleroderma, Systemic; Thromboembolism; Vascular Diseases
詳細
SparsentanPS-433540; BMS-346567; RE-021ApprovedBristol-Myers Squibb CompanyFilspariUnited StatesGlomerulonephritis, IGATravere Therapeutics Inc2023-02-17
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Autoimmune Diseases; Cardiovascular Diseases; Glomerulonephritis; Glomerulonephritis, IGA; Glomerulosclerosis, Focal Segmental; Hypertension; Immune System Diseases; Kidney Diseases; Nephritis, Hereditary; Nephrosis, Lipoid; Proteinuria; Purpura, Schoenlein-Henoch
詳細
Bosentan HydrateACT-050088; HGP-1206; Ro-47-0203; Ro-47-0203/029; Ro-47-0203/039ApprovedF. Hoffmann-La Roche LtdStayveer, 全可利, TracleerUnited StatesPulmonary Arterial HypertensionActelion Pharmaceuticals Ltd2001-11-20
Anemia, Sickle Cell; Chronic thromboembolic pulmonary hypertension; Coronary Vasospasm; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fibrosis; Giant Cell Arteritis; Glaucoma; Heart Defects, Congenital; Heart Septal Defects, Atrial; Hepatopulmonary Syndrome; Hypertension; Hypertension, Pulmonary; Idiopathic Pulmonary Fibrosis; Liver Cirrhosis; Lung Diseases, Interstitial; Persistent Fetal Circulation Syndrome; Pulmonary Arterial Hypertension; Pulmonary Fibrosis; Sarcoidosis; Scleroderma, Systemic; Sleep Apnea Syndromes; Takayasu Arteritis; Ulcer; Vasculitis
詳細
MacitentanACT-064992; Actelion-1; JNJ-67896062ApprovedActelion Pharmaceuticals LtdZependo, Opsumit, 傲朴舒United StatesPulmonary Arterial HypertensionActelion Pharmaceuticals Us Inc2013-10-18
Anemia, Sickle Cell; Angina Pectoris; Chronic Disease; Chronic thromboembolic pulmonary hypertension; Eisenmenger Complex; Glioblastoma; Heart Defects, Congenital; Heart Failure; Heart Failure, Diastolic; Hypertension, Pulmonary; Idiopathic Pulmonary Fibrosis; Pulmonary Arterial Hypertension; Pulmonary Embolism; Scleroderma, Systemic; Scleroderma-associated interstitial lung diseases; Thromboembolism; Ulcer
詳細
AprocitentanACT-132577; AC-080; JNJ-2820ApprovedActelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals LtdTRYVIO, JERAYGOUnited StatesHypertensionIdorsia Pharmaceuticals Ltd2024-03-19
Essential Hypertension; Hepatic Insufficiency; Hypertension; Renal Insufficiency, Chronic
詳細
Atrasentan hydrochlorideABT-147627; (+)-A-127722; Abbott-147627; A-147627; ABT-627; A-1476271; CHK-01; EXV 811ApprovedAbbvie IncVanrafia, 诺锐达, XinlayUnited StatesGlomerulonephritis, IGA; ProteinuriaNovartis Pharmaceutical Corp, Novartis Pharma Ag2025-04-02
Abdominal Neoplasms; Adenocarcinoma; CNS Embryonal Tumor; Diabetes Mellitus; Diabetic Nephropathies; Fallopian Tube Neoplasms; Glomerulonephritis, IGA; Glomerulosclerosis, Focal Segmental; Kidney Diseases; Kidney Neoplasms; Neoplasm Metastasis; Nephritis, Hereditary; Ovarian Neoplasms; Prostatic Neoplasms; Proteinuria; Renal Insufficiency, Chronic; Vascular Diseases
詳細