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EDNRA

EDNRA 詳細

英語名Endothelin receptor type A市販薬剤の数8
治験薬の数11ターゲットの別称Endothelin Receptor Type A，EDNRA，ETA-R，Endothelin-1 receptor，hET-AR，ETRA，ET-A，ETA，Endothelin-1-Specific Receptor，Endothelin Receptor Subtype A，G Protein-Coupled Receptor，ETAR，MFDA，Receptor， Endothelin A
研究＆開発段階Approved
英語名Endothelin receptor type A
ターゲットの別称Endothelin Receptor Type A，EDNRA，ETA-R，Endothelin-1 receptor，hET-AR，ETRA，ET-A，ETA，Endothelin-1-Specific Receptor，Endothelin Receptor Subtype A，G Protein-Coupled Receptor，ETAR，MFDA，Receptor， Endothelin A
市販薬剤の数8
治験薬の数11
研究＆開発段階Approved

EDNRA 製品リスト

  • 属性

    Protein (2)

  • 製品ライブラリ

    オンライン (2)

  • 種

    Human (2)

  • タグ

    - (1)His Tag & Flag Tag (1)

  • マーカー

    Unconjugated (2)

製品番号種発現システム製品説明タンパク質の構造純度特性
EDA-H51D3
Human
E. coli
Human EDNRA Full Length Protein, His,Flag Tag (Detergent)
EDA-H52P8
Human
HEK293
Human EDNRA Full Length Protein (VLP)
総数量2
  • 1

EDNRAバックグランド

EDNRA encodes the endothelin type A receptor, a G protein-coupled receptor mediating vasoconstriction and cell proliferation upon endothelin-1 binding. Overexpression contributes to pulmonary arterial hypertension, cardiovascular disorders, and cancer progression. Selective EDNRA antagonists offer therapeutic potential for managing hypertension, fibrosis, and tumor angiogenesis.

EDNRA分子の別称

endothelin receptor type A, ETA,ET-A,ETAR,ETRA,MFDA,ETA-R,hET-AR

治験薬に関する情報

英語名研究コード研究開発ステージ会社適応症臨床試験
SC-0062SC-0062; WX-013Phase 3 ClinicalShijiazhuang Zhikang Hongren New Drug Development Co LtdAltitude Sickness; Diabetic Nephropathies; Glomerulonephritis, IGA; Kidney Diseases; Pulmonary Arterial Hypertension
詳細
Zibotentan/DapagliflozinPhase 3 ClinicalAstrazeneca Ab, AstraZeneca global R & D (China) Co LtdAlbuminuria; Kidney Diseases; Renal Insufficiency, Chronic
詳細
PatecibartGMA-301; GMA-301-A; GMA-301-BPhase 2 ClinicalGmax Biopharm LlcPulmonary Arterial Hypertension
詳細
ZibotentanZD-4054; AZD-4054Phase 2 ClinicalAstrazeneca PlcCarcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Hepatic Insufficiency; Hypertension, Portal; Intermittent Claudication; Liver Cirrhosis; Lung Neoplasms; Metastatic breast cancer; Microvascular Angina; Neoplasm Metastasis; Ovarian Neoplasms; Peripheral Arterial Disease; Prostatic Neoplasms; Renal Insufficiency; Renal Insufficiency, Chronic; Scleroderma, Limited; Scleroderma, Systemic; Solid tumours
詳細
SAL-0120SAL-0120; SAL0120Phase 2 ClinicalShenzhen Salubris Pharmaceuticals Co LtdEssential Hypertension; Glomerulonephritis, IGA; Hypertension; Renal Insufficiency, Chronic
詳細
HS-10390HS-10390; HS10390Phase 2 ClinicalChangzhou Hengbang Pharmaceutical Co Ltd, Shanghai Hansoh Biomedical Co LtdGlomerulonephritis, IGA; Glomerulosclerosis, Focal Segmental; Renal Insufficiency, Chronic
詳細
BQ-123CGS-26343; BQ-123; PMZ-2123Phase 1 ClinicalMidwestern UniversityCardiovascular Diseases; Coronary Artery Disease; Diabetic Ketoacidosis; Heart Failure; Hypertension; Hypertension, Pulmonary; Hypoxia, Brain; Metabolic Syndrome; Multiple System Atrophy; Pain; Proteinuria; Pure Autonomic Failure; Renal Insufficiency, Chronic; ST Elevation Myocardial Infarction
詳細
GMA-131GMA-131Phase 1 ClinicalGmax Biopharm Llc, Gmaxx Biologics LtdDiabetic Nephropathies
詳細
AK-1960AK1960; AK-1960Phase 1 ClinicalRenal Insufficiency, Chronic
詳細
GLX-002GLX-002; GLX002Phase 1 ClinicalYabao Pharmaceutical Co Ltd BeijingPulmonary Arterial Hypertension
詳細
Bosentan Orally Disintegrating Tablets(Beijing Sunho Pharma)Phase 1 ClinicalBeijing Sunho Pharmaceutical Co LtdPulmonary Arterial Hypertension
詳細

市販薬剤に関する情報

英語名研究コード研究開発ステージ会社オリジナル製品名最初に承認をした国最初の適応症最初に承認を受けた会社承認された日付適応症臨床試験
Clazosentan SodiumRo-61-1790; ACT-108475; AXV-034; VML-588; AXV-034343ApprovedF. Hoffmann-La Roche LtdPivlazJapanSubarachnoid Hemorrhage; Brain Ischemia; Vasospasm, Intracranial; Cerebral InfarctionIdorsia Pharmaceuticals Ltd2022-01-20Aneurysm; Brain Ischemia; Cerebral Infarction; Subarachnoid Hemorrhage; Vasospasm, Intracranial
詳細
Macitentan/TadalafilApprovedActelion Pharmaceuticals LtdOPSYNVI, YuvanciUnited StatesPulmonary Arterial HypertensionActelion Pharmaceuticals Us Inc2024-03-22Phenylketonurias; Pulmonary Arterial Hypertension
詳細
AmbrisentanLU-208075; BSF-208075; GSK-132576AApprovedAbbott LaboratoriesLetairis, Volibris, 凡瑞克United StatesPulmonary Arterial HypertensionGilead Sciences Inc2007-06-15Acute Kidney Injury; Anemia, Sickle Cell; Ascites; Coronavirus Disease 2019 (COVID-19); Hepatorenal Syndrome; Hypertension; Hypertension, Portal; Hypertension, Pulmonary; Hypoxia; Idiopathic Pulmonary Fibrosis; Liver Cirrhosis; Pulmonary Arterial Hypertension; Sarcoidosis; Scleroderma, Systemic; Thromboembolism; Vascular Diseases
詳細
SparsentanPS-433540; BMS-346567; RE-021ApprovedBristol-Myers Squibb CompanyFilspariUnited StatesGlomerulonephritis, IGATravere Therapeutics Inc2023-02-17Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Autoimmune Diseases; Cardiovascular Diseases; Glomerulonephritis; Glomerulonephritis, IGA; Glomerulosclerosis, Focal Segmental; Hypertension; Immune System Diseases; Kidney Diseases; Nephritis, Hereditary; Nephrosis, Lipoid; Proteinuria; Purpura, Schoenlein-Henoch
詳細
Bosentan HydrateACT-050088; HGP-1206; Ro-47-0203; Ro-47-0203/029; Ro-47-0203/039ApprovedF. Hoffmann-La Roche LtdStayveer, 全可利, TracleerUnited StatesPulmonary Arterial HypertensionActelion Pharmaceuticals Ltd2001-11-20Anemia, Sickle Cell; Chronic thromboembolic pulmonary hypertension; Coronary Vasospasm; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fibrosis; Giant Cell Arteritis; Glaucoma; Heart Defects, Congenital; Heart Septal Defects, Atrial; Hepatopulmonary Syndrome; Hypertension; Hypertension, Pulmonary; Idiopathic Pulmonary Fibrosis; Liver Cirrhosis; Lung Diseases, Interstitial; Persistent Fetal Circulation Syndrome; Pulmonary Arterial Hypertension; Pulmonary Fibrosis; Sarcoidosis; Scleroderma, Systemic; Sleep Apnea Syndromes; Takayasu Arteritis; Ulcer; Vasculitis
詳細
MacitentanACT-064992; Actelion-1; JNJ-67896062ApprovedActelion Pharmaceuticals LtdZependo, Opsumit, 傲朴舒United StatesPulmonary Arterial HypertensionActelion Pharmaceuticals Us Inc2013-10-18Anemia, Sickle Cell; Angina Pectoris; Chronic Disease; Chronic thromboembolic pulmonary hypertension; Eisenmenger Complex; Glioblastoma; Heart Defects, Congenital; Heart Failure; Heart Failure, Diastolic; Hypertension, Pulmonary; Idiopathic Pulmonary Fibrosis; Pulmonary Arterial Hypertension; Pulmonary Embolism; Scleroderma, Systemic; Scleroderma-associated interstitial lung diseases; Thromboembolism; Ulcer
詳細
AprocitentanACT-132577; AC-080; JNJ-2820ApprovedActelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals LtdTRYVIO, JERAYGOUnited StatesHypertensionIdorsia Pharmaceuticals Ltd2024-03-19Essential Hypertension; Hepatic Insufficiency; Hypertension; Renal Insufficiency, Chronic
詳細
Atrasentan hydrochlorideABT-147627; (+)-A-127722; Abbott-147627; A-147627; ABT-627; A-1476271; CHK-01; EXV 811ApprovedAbbvie IncVanrafia, 诺锐达, XinlayUnited StatesGlomerulonephritis, IGA; ProteinuriaNovartis Pharmaceutical Corp, Novartis Pharma Ag2025-04-02Abdominal Neoplasms; Adenocarcinoma; CNS Embryonal Tumor; Diabetes Mellitus; Diabetic Nephropathies; Fallopian Tube Neoplasms; Glomerulonephritis, IGA; Glomerulosclerosis, Focal Segmental; Kidney Diseases; Kidney Neoplasms; Neoplasm Metastasis; Nephritis, Hereditary; Ovarian Neoplasms; Prostatic Neoplasms; Proteinuria; Renal Insufficiency, Chronic; Vascular Diseases
詳細
  • 詳細
  • 製品リスト
  • 市販薬剤に関する情報
  • 治験薬に関する情報
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