EDNRB
EDNRB 詳細
| 英語名 | Endothelin receptor type B | 市販薬剤の数 | 5 |
| 治験薬の数 | 5 | ターゲットの別称 | Hirschsprung Disease 2，Endothelin receptor non-selective type，ET-B，Endothelin receptor type B，EDNRB，ET-BR，ETRB，Endothelin Receptor Subtype B1，ABCDS，HSCR2，ETB1，ETBR，WS4A，HSCR，ETB，Receptor， Endothelin B |
| 研究＆開発段階 | Approved | ||
| 英語名 | Endothelin receptor type B |
| ターゲットの別称 | Hirschsprung Disease 2，Endothelin receptor non-selective type，ET-B，Endothelin receptor type B，EDNRB，ET-BR，ETRB，Endothelin Receptor Subtype B1，ABCDS，HSCR2，ETB1，ETBR，WS4A，HSCR，ETB，Receptor， Endothelin B |
| 市販薬剤の数 | 5 |
| 治験薬の数 | 5 |
| 研究＆開発段階 | Approved |
EDNRB 製品リスト
- 属性
Protein (4)
- 製品ライブラリ
オンライン (4)
- 種
Human (4)
- タグ
- (2)GFP Tag (1)His Tag & Flag Tag (1)
- マーカー
Unconjugated (3)GFP Fusion (1)
| 製品番号 | 種 | 発現システム | 製品説明 | タンパク質の構造 | 純度 | 特性 |
|---|---|---|---|---|---|---|
 Human | HEK293 | Human EDNRB Protein, Flag,His Tag (Detergent) |  |  |  | |
| Human | E. coli | Human EDNRB Full Length Protein, His,Flag Tag (Detergent) |  | | ||
| Human | HEK293 | Human EDNRB Full Length Protein (VLP) | | |||
| Human | HEK293 | Fluorescent Human EDNRB Full Length Protein (VLP) | |
総数量4
- 1
EDNRBバックグランド
Endothelin Receptor B (EDNRB) is a type of G protein-coupled Receptor with the N-terminus located outside the cell. It's widespread in the human body. EDNRB binds to ET and transmits information into the cell through the intracellular Ca2+ phospholipid-dependent protein kinase second messenger system, which promotes the rapid release of calcium in the endoplasmic reticulum and sarcoplasmic reticulum, resulting in the rapid increase of intracellular calcium concentration. Endothelin exerts its biological effects through its receptor (ETR). Endothelin and ETR constitute the endothelin axis. Endothelin axis has pro-tumor effects in various tumors including malignant melanoma (MM), including promoting tumor growth, anti-apoptosis, promoting angiogenesis and promoting tumor metastasis.
EDNRB分子の別称
EDNRB,endothelin receptor type B,ABCDS, ET-B, ET-BR, ETB, ETB1, ETBR, ETRB, HSCR, HSCR2, WS4A
治験薬に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|
| VRP-1620 | VRP-1620 | Phase 3 Clinical | University Of Illinois | Breast Neoplasms | 詳細 |
| Vodudeutentan | ENB-003; ENB-006 | Phase 2 Clinical | Enb Therapeutics Inc | Melanoma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Solid tumours | 詳細 |
| BQ-788 | BQ-788 | Phase 1 Clinical | Merck Serono | Cardiovascular Diseases; Hypertension; Melanoma | 詳細 |
| GLX-002 | GLX-002; GLX002 | Phase 1 Clinical | Yabao Pharmaceutical Co Ltd Beijing | Pulmonary Arterial Hypertension | 詳細 |
| Bosentan Orally Disintegrating Tablets(Beijing Sunho Pharma) | Phase 1 Clinical | Beijing Sunho Pharmaceutical Co Ltd | Pulmonary Arterial Hypertension | 詳細 |
市販薬剤に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | オリジナル製品名 | 最初に承認をした国 | 最初の適応症 | 最初に承認を受けた会社 | 承認された日付 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|---|---|---|---|---|
| Sovateltide | IRL-1620; PMZ-1620; SPI-1620 | Approved | University Of Illinois At Chicago | Tyvalzi | India | Stroke | Pharmazz Inc | 2023-05-31 | Alzheimer Disease; Asphyxia Neonatorum; Biliary Tract Neoplasms; Brain Diseases; Brain Ischemia; Carcinoma; Carcinoma, Non-Small-Cell Lung; Cerebral Infarction; Dementia; Ischemic Stroke; Spinal Cord Injuries; Stroke | 詳細 |
| Macitentan/Tadalafil | Approved | Actelion Pharmaceuticals Ltd | OPSYNVI, Yuvanci | United States | Pulmonary Arterial Hypertension | Actelion Pharmaceuticals Us Inc | 2024-03-22 | Phenylketonurias; Pulmonary Arterial Hypertension | 詳細 | |
| Bosentan Hydrate | ACT-050088; HGP-1206; Ro-47-0203; Ro-47-0203/029; Ro-47-0203/039 | Approved | F. Hoffmann-La Roche Ltd | Stayveer, 全可利, Tracleer | United States | Pulmonary Arterial Hypertension | Actelion Pharmaceuticals Ltd | 2001-11-20 | Anemia, Sickle Cell; Chronic thromboembolic pulmonary hypertension; Coronary Vasospasm; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fibrosis; Giant Cell Arteritis; Glaucoma; Heart Defects, Congenital; Heart Septal Defects, Atrial; Hepatopulmonary Syndrome; Hypertension; Hypertension, Pulmonary; Idiopathic Pulmonary Fibrosis; Liver Cirrhosis; Lung Diseases, Interstitial; Persistent Fetal Circulation Syndrome; Pulmonary Arterial Hypertension; Pulmonary Fibrosis; Sarcoidosis; Scleroderma, Systemic; Sleep Apnea Syndromes; Takayasu Arteritis; Ulcer; Vasculitis | 詳細 |
| Macitentan | ACT-064992; Actelion-1; JNJ-67896062 | Approved | Actelion Pharmaceuticals Ltd | Zependo, Opsumit, 傲朴舒 | United States | Pulmonary Arterial Hypertension | Actelion Pharmaceuticals Us Inc | 2013-10-18 | Anemia, Sickle Cell; Angina Pectoris; Chronic Disease; Chronic thromboembolic pulmonary hypertension; Eisenmenger Complex; Glioblastoma; Heart Defects, Congenital; Heart Failure; Heart Failure, Diastolic; Hypertension, Pulmonary; Idiopathic Pulmonary Fibrosis; Pulmonary Arterial Hypertension; Pulmonary Embolism; Scleroderma, Systemic; Scleroderma-associated interstitial lung diseases; Thromboembolism; Ulcer | 詳細 |
| Aprocitentan | ACT-132577; AC-080; JNJ-2820 | Approved | Actelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals Ltd | TRYVIO, JERAYGO | United States | Hypertension | Idorsia Pharmaceuticals Ltd | 2024-03-19 | Essential Hypertension; Hepatic Insufficiency; Hypertension; Renal Insufficiency, Chronic | 詳細 |
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