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Endoglin

Endoglin 詳細

英語名	Endoglin	市販薬剤の数	0
治験薬の数	2	ターゲットの別称	CD105 Antigen，CD105，END，ENG，Osler-Rendu-Weber Syndrome 1，HHT1，ORW1，Endoglin
研究＆開発段階	Phase 2 Clinical

英語名	Endoglin
ターゲットの別称	CD105 Antigen，CD105，END，ENG，Osler-Rendu-Weber Syndrome 1，HHT1，ORW1，Endoglin
市販薬剤の数	0
治験薬の数	2
研究＆開発段階	Phase 2 Clinical

Endoglin 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
His Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
ENN-H52H9	Human	HEK293	Human Endoglin / CD105 Protein, His Tag

総数量1

Endoglinバックグランド

Endoglin (ENG), endothelial glycoprotein, also known as CD105, is a coreceptor of the transforming growth factor-β (TGFβ) family signaling complex, which is highly expressed on endothelial cells and plays a key role in angiogenesis. It regulates the responses associated with binding to transforming growth factor β1 egg (Activin-A), bone morphogenetic protein 2 (BMP-2), and bone morphogenetic protein 7 (BMP-7). Endoglin may be involved in autosomal dominant disease, such as hereditary hemorrhagic telangiectasia 1 (HHT1). Circulating soluble ENG is also elevated in pulmonary arterial hypertension(PAH) and is proposed to be a biomarker for the prognosis of group I PAH patients.

Endoglin分子の別称

Endoglin,CD105,ENG,END

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Carotuximab	DE-122; TRC-105; NSC#754227; Chimeric Antibody TRC-105; ENV-105	Phase 2 Clinical	Roswell Park Cancer Institute	Adenoma, Liver Cell; Astrocytoma; Brain Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Choriocarcinoma; Fallopian Tube Neoplasms; Gestational Trophoblastic Disease; Glioblastoma; Glioma; Gliosarcoma; Hemangiosarcoma; Liver Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Macular Degeneration; Metastatic breast cancer; Neoplasm Metastasis; Neoplasms; Oligodendroglioma; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Solid tumours; Trophoblastic Neoplasms; Trophoblastic Tumor, Placental Site; Ureteral Neoplasms	詳細
STEMVAC	EP-101	Phase 2 Clinical	Epithany	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; HR-positive breast cancer; Lung Neoplasms; Triple Negative Breast Neoplasms	詳細