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ENPP-2

ENPP-2 詳細

英語名	Ectonucleotide pyrophosphatase/phosphodiesterase 2	市販薬剤の数	0
治験薬の数	9	ターゲットの別称	EC:3.1.4.39，ATX，Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2，Phosphodiesterase I/Nucleotide Pyrophosphatase 2，Plasma Lysophospholipase D，Autotaxin-T，EC 3.1.4.39，PD-IALPHA，ATX-X，NPP2，E-NPP 2，Autotaxin，ENPP2，PDNP2，Ectonucleotide Pyrophosphatase/Phosphodiesterase 2，Extracellular Lysophospholipase D，LysoPLD
研究＆開発段階	Phase 2 Clinical

英語名	Ectonucleotide pyrophosphatase/phosphodiesterase 2
ターゲットの別称	EC:3.1.4.39，ATX，Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2，Phosphodiesterase I/Nucleotide Pyrophosphatase 2，Plasma Lysophospholipase D，Autotaxin-T，EC 3.1.4.39，PD-IALPHA，ATX-X，NPP2，E-NPP 2，Autotaxin，ENPP2，PDNP2，Ectonucleotide Pyrophosphatase/Phosphodiesterase 2，Extracellular Lysophospholipase D，LysoPLD
市販薬剤の数	0
治験薬の数	9
研究＆開発段階	Phase 2 Clinical

ENPP-2 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
His Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
EN2-H5241	Human	HEK293	Human ENPP-2 / Autotaxin Protein, His Tag (active enzyme)

総数量1

ENPP-2バックグランド

Autotaxin also known as ectonucleotide pyrophosphatase / phosphodiesterase family member 2 (E-NPP 2 or ENPP2), Extracellular lysophospholipase D (LysoPLD), Autotaxin (ATX or ATX-X), which belongs to the nucleotide pyrophosphatase / phosphodiesterase family. ENPP2 contains two SMB (somatomedin-B) domains. ENPP2 hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. ENPP2 can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. ENPP2 stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein.

ENPP-2分子の別称

ENPP-2,E-NPP 2,Autotaxin,LysoPLD,ATX,PDNP2,ATX-X,NPP2,PD-IALPHA

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
BBT-877	BBT-877	Phase 2 Clinical	Legochem	Idiopathic Pulmonary Fibrosis	詳細
Cambritaxestat	CRT-0273750; IOA-289	Phase 2 Clinical	Cancer Research Technology, Merck & Co	Pancreatic Neoplasms; Solid tumours	詳細
HRS-9813	HRS-9813; HRS9813	Phase 2 Clinical	Guangdong Hengrui Pharmaceutical Co Ltd	Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis	詳細
HW-021199	HW-021199	Phase 2 Clinical	Hubei Bio-Pharmaceutical Industrial Technological Institute Inc, Humanwell Puracap (Likang) Pharmaceuticals Co Ltd	Idiopathic Pulmonary Fibrosis	詳細
HNC664	HNC664; HNC-664	Phase 1 Clinical	Guangzhou Henovcom Bioscience Co Ltd	Idiopathic Pulmonary Fibrosis; Pancreatic Neoplasms	詳細
Cudetaxestat	PAT-409; BLD-0409	Phase 1 Clinical	Blade Therapeutics Inc	Idiopathic Pulmonary Fibrosis; Liver Diseases; Metabolic Dysfunction-Associated Steatotic Liver Disease	詳細
NXC-680	NXC-680	Phase 1 Clinical	Nextgen Bioscience Inc	Idiopathic Pulmonary Fibrosis	詳細
HNC-1058	HNC-1058	Phase 1 Clinical	Guangzhou Henovcom Bioscience Co Ltd	Idiopathic Pulmonary Fibrosis	詳細
FTP-198	FTP-198	Phase 1 Clinical	Haisco Pharmaceutical Group Co Ltd	Idiopathic Pulmonary Fibrosis	詳細