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EphA4

EphA4 詳細

英語名	Erythropoietin-producing hepatocellular receptor A4	市販薬剤の数	0
治験薬の数	3	ターゲットの別称	Ephrin type-A receptor 4，EPH-like kinase 8 (EK8; hEK8)，Tyrosine-protein kinase TYRO1，Tyrosine-protein kinase receptor SEK，EPH Receptor A4，TYRO1，HEK8，Tyrosine-Protein Kinase Receptor SEK，Tyrosine-Protein Kinase TYRO1，Ephrin Type-A Receptor 4，EPH-Like Kinase 8，EC 2.7.10.1，EK8，SEK，Receptor Protein-Tyrosine Kinase HEK8，TYRO1 Protein Tyrosine Kinase，EC 2.7.10
研究＆開発段階	Phase 1 Clinical

英語名	Erythropoietin-producing hepatocellular receptor A4
ターゲットの別称	Ephrin type-A receptor 4，EPH-like kinase 8 (EK8; hEK8)，Tyrosine-protein kinase TYRO1，Tyrosine-protein kinase receptor SEK，EPH Receptor A4，TYRO1，HEK8，Tyrosine-Protein Kinase Receptor SEK，Tyrosine-Protein Kinase TYRO1，Ephrin Type-A Receptor 4，EPH-Like Kinase 8，EC 2.7.10.1，EK8，SEK，Receptor Protein-Tyrosine Kinase HEK8，TYRO1 Protein Tyrosine Kinase，EC 2.7.10
市販薬剤の数	0
治験薬の数	3
研究＆開発段階	Phase 1 Clinical

EphA4 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
His Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
EP4-H52H8	Human	HEK293	Human EphA4 Protein, His Tag

総数量1

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EphA4バックグランド

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

EphA4分子の別称

EphA4,HEK8,SEK,TYRO1,EK8

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
ORT-247	ORT247; ORT-247	Phase 1 Clinical	Orthogonal Neuroscience Inc	Amyotrophic Lateral Sclerosis	詳細
mEphA4-Fc	mEphA4-Fc	Phase 1 Clinical	Queensland Brain Institute	Amyotrophic Lateral Sclerosis; Nerve Degeneration; Nervous System Diseases	詳細
E2025	E-2025; E2025	Phase 1 Clinical	Eisai Inc	Alzheimer Disease	詳細