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EphA5

EphA5 詳細

英語名	EPH Receptor A5	市販薬剤の数	0
治験薬の数	1	ターゲットの別称	EPHA5，BSK，EphA5，EC 2.7.10，Receptor Protein-Tyrosine Kinase HEK7，Tyrosine-Protein Kinase Receptor EHK-1，Epididymis Secretory Sperm Binding Protein，EK7，Hek7，EHK-1，EC 2.7.10.1，EPH-like kinase 7，EPH-Like Kinase，EPH homology kinase 1，Brain-Specific Kinase，EPH Homology Kinase，Ephrin type-A receptor 5，Ephrin Type-A Receptor，HEK7，CEK7，EHK1，TYRO4
研究＆開発段階	Phase 2 Clinical

英語名	EPH Receptor A5
ターゲットの別称	EPHA5，BSK，EphA5，EC 2.7.10，Receptor Protein-Tyrosine Kinase HEK7，Tyrosine-Protein Kinase Receptor EHK-1，Epididymis Secretory Sperm Binding Protein，EK7，Hek7，EHK-1，EC 2.7.10.1，EPH-like kinase 7，EPH-Like Kinase，EPH homology kinase 1，Brain-Specific Kinase，EPH Homology Kinase，Ephrin type-A receptor 5，Ephrin Type-A Receptor，HEK7，CEK7，EHK1，TYRO4
市販薬剤の数	0
治験薬の数	1
研究＆開発段階	Phase 2 Clinical

EphA5 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
His Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
EP5-H52H5	Human	HEK293	Human EphA5 Protein, His Tag (MALS verified)

総数量1

EphA5バックグランド

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance.