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EphB4

EphB4 詳細

英語名	Ephrin type-B receptor 4	市販薬剤の数	0
治験薬の数	2	ターゲットの別称	Ephrin type-B receptor 4，MYK1，EPHB4，HTK，EPH Receptor B4，Tyrosine-Protein Kinase TYRO11，TYRO11，Tyrosine-Protein Kinase Receptor HTK，Soluble EPHB4 Variant 2，Soluble EPHB4 Variant 3，Ephrin Receptor EphB4，EC 2.7.10.1，HFASD，LMPHM7，CMAVM2，EC 2.7.10，EC:2.7.10.1，Soluble EPHB4 Variant 1，Receptor， EphB4，Hepatoma transmembrane kinase
研究＆開発段階	Phase 3 Clinical

英語名	Ephrin type-B receptor 4
ターゲットの別称	Ephrin type-B receptor 4，MYK1，EPHB4，HTK，EPH Receptor B4，Tyrosine-Protein Kinase TYRO11，TYRO11，Tyrosine-Protein Kinase Receptor HTK，Soluble EPHB4 Variant 2，Soluble EPHB4 Variant 3，Ephrin Receptor EphB4，EC 2.7.10.1，HFASD，LMPHM7，CMAVM2，EC 2.7.10，EC:2.7.10.1，Soluble EPHB4 Variant 1，Receptor， EphB4，Hepatoma transmembrane kinase
市販薬剤の数	0
治験薬の数	2
研究＆開発段階	Phase 3 Clinical

EphB4 製品リスト

属性
Protein (2)
製品ライブラリ
オンライン (2)
種
Human (2)
タグ
His Tag (2)
マーカー
Unconjugated (1)Biotin-labeled (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
EP4-H5229	Human	HEK293	Human EphB4 Protein, His Tag
EP4-H8229	Human	HEK293	Biotinylated Human EphB4 Protein, His Tag, ultra sensitivity (primary amine labeling)

総数量2

EphB4バックグランド

Ephrin type-B receptor 4(EPHB4) is also known as HTK, MYK1 and TYRO11,is a member of Eph family. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EPHB4 binds to Ephrin-B2 and plays an essential role in vascular development. EPHB4 and its ligand ephrin-B2 are specifically expressed on venous and arterial endothelial cells, respectively, and play an essential role in vascular development via bidirectional signals. The forward EPHB4 signaling inhibits cell adhesion, chemotaxis, angiogenesis and tumor growth. Incontrast, the reverse Ephrin-B2 signaling exerts the opposite effect. It has been reported that aberrant expression of EPHB4 is associated with prostate cancer and highly malignant breast cancers, accordingly, EPHB4 has potential application as a therapeutic candidate.

EphB4分子の別称

EphB4,HTK,MYK1,TYRO11

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
sEphB4-HSA	Vas-01; sEphB4-HSA	Phase 3 Clinical	Vasgene	Bile Duct Neoplasms; Bone metastases; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Gallbladder Neoplasms; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Myelodysplastic-Myeloproliferative Diseases; Pancreatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Sarcoma, Kaposi; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Urinary Bladder Neoplasms	詳細
Tesevatinib	XL-647; KD-020; KD-019; EXEL-7647	Phase 2 Clinical	Exelixis Inc	Brain metastases; Brain Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Glioblastoma; Neoplasm Metastasis; Neoplasms; Polycystic Kidney, Autosomal Dominant; Polycystic Kidney, Autosomal Recessive	詳細