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Fc gamma RIIB / CD32b

Fc gamma RIIB / CD32b Overview

English Name	Low affinity immunoglobulin gamma Fc region receptor II-b	Approved Drugs	0
Drugs in Clinical Trials	5	Target Synonym	IgG Fc Receptor II-C，Fc Fragment Of IgG， Low Affinity IIb， Receptor (CD32)，Fc Gamma Receptor IIb，IgG Fc Receptor II-B，Fc-Gamma RII-B，FcRII-B，CDw32，FCG2，Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B，Fc Fragment Of IgG， Low Affinity II， Receptor For (CD32)，Fc Gamma RIIb，CD32 Antigen，CD32B，FCGR2，Fc-gamma-RIIb，FCGR2B，IGFR2，CD32，Fc Fragment Of IgG Receptor IIb，Fc-Gamma RII-C，Low Affinity Immunoglobulin Gamma Fc Region Receptor II-C，Fc Fragment Of IgG， Low Affinity IIb， Receptor For (CD32)，FcRII-C，FCGR2C，Fc-Gamma-RIIc
Highest Development Stage	Phase 3 Clinical

English Name	Low affinity immunoglobulin gamma Fc region receptor II-b
Target Synonym	IgG Fc Receptor II-C，Fc Fragment Of IgG， Low Affinity IIb， Receptor (CD32)，Fc Gamma Receptor IIb，IgG Fc Receptor II-B，Fc-Gamma RII-B，FcRII-B，CDw32，FCG2，Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B，Fc Fragment Of IgG， Low Affinity II， Receptor For (CD32)，Fc Gamma RIIb，CD32 Antigen，CD32B，FCGR2，Fc-gamma-RIIb，FCGR2B，IGFR2，CD32，Fc Fragment Of IgG Receptor IIb，Fc-Gamma RII-C，Low Affinity Immunoglobulin Gamma Fc Region Receptor II-C，Fc Fragment Of IgG， Low Affinity IIb， Receptor For (CD32)，FcRII-C，FCGR2C，Fc-Gamma-RIIc
Approved Drugs	0
Drugs in Clinical Trials	5
Highest Development Stage	Phase 3 Clinical

Fc gamma RIIB / CD32b Product List

Product Category
Protein (5)Cell (4)
Product Status
Launched (9)
Species
Mouse (2)Cynomolgus (2)Human (4)Rat (1)
Tag
His Tag (3)His Tag & Avi Tag (2)- (4)
Conjugate
Unconjugated (3)Biotin-labeled (2)- (4)

Cat. No.	Species	Host	Product Description
HOT SCJUR-STF071	Human	Jurkat	Human CD32b (Luc) Jurkat Reporter Cell
HOT CDB-M52H7	Mouse	HEK293	Mouse Fc gamma RIIB / CD32b Protein, His Tag (SPR & MALS verified)
HOT CDB-M82E8	Mouse	HEK293	Biotinylated Mouse Fc gamma RIIB / CD32b Protein, Avitag™,His Tag (SPR & MALS verified)
HOT CDB-C5224	Cynomolgus	HEK293	Cynomolgus Fc gamma RIIB / CD32b Protein, His Tag (MALS & SPR verified)
HOT CDB-R52H3	Rat	HEK293	Rat Fc gamma RIIB / CD32b Protein, His Tag (MALS verified)
SCCHO-ATP060H	Human	CHO	CHO/Human CD32b Stable Cell Line (High Expression)
SCCHO-ATP060L	Human	CHO	CHO/Human CD32b Stable Cell Line (Low Expression)
SCCHO-ATP060M	Human	CHO	CHO/Human CD32b Stable Cell Line (Medium Expression)
CDB-C82E4	Cynomolgus	HEK293	Biotinylated Cynomolgus Fc gamma RIIB / CD32b Protein, His,Avitag™ (SPR & MALS verified)

Total: 9

Fc gamma RIIB / CD32b Background

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.

Fc gamma RIIB / CD32b Synonyms

FCGR

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Obexelimab	XmAb-5871; AMG-729	Phase 3 Clinical	Xencor Inc	Anemia, Hemolytic, Autoimmune; Immunoglobulin G4-Related Disease; Lupus Erythematosus, Systemic; Multiple Sclerosis	Details
BI-1206	6G-11; BI-1206	Phase 2 Clinical	Bioinvent International Ab	Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Solid tumours; Waldenstrom Macroglobulinemia	Details
BI-1607	BI-1607	Phase 2 Clinical	Bioinvent International Ab	Adenocarcinoma; Breast Neoplasms; Esophageal Neoplasms; Melanoma; Metastatic breast cancer; Skin Melanoma; Solid tumours; Stomach Neoplasms; Uveal melanoma	Details
NVG-2089	NVG-2089	Phase 2 Clinical	Nuvig Therapeutics Inc	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Purpura, Thrombocytopenic, Idiopathic	Details
S-4321	S-4321	Phase 1 Clinical	Seismic Therapeutics Inc	Arthritis, Psoriatic; Arthritis, Rheumatoid; Autoimmune Diseases; Dermatitis, Atopic; Immune System Diseases; Lupus Erythematosus, Cutaneous; Psoriasis	Details