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Fc gamma RIII / CD16

Fc gamma RIII / CD16 詳細

英語名	Low affinity immunoglobulin gamma Fc region receptor III-A	市販薬剤の数	0
治験薬の数	14	ターゲットの別称	IGFR3，FCG3，Fc Fragment Of IgG， Low Affinity IIIa， Receptor For (CD16)，Fc Fragment Of IgG， Low Affinity III， Receptor For (CD16)，Immunoglobulin G Fc Receptor III，Fc-Gamma Receptor III-2 (CD 16)，Neutrophil-Specific Antigen NA，Fc-Gamma Receptor IIIb (CD16)，Fc Gamma Receptor III-A，Low Affinity Immunoglobulin Gamma Receptor III-A Fc Fragment，IgG Fc receptor III-2，Low affinity immunoglobulin gamma Fc region receptor III-A，FCGR3，CD16A，Fc-gamma RIII-alpha，FCGR3A，Fc Fragment Of IgG Receptor IIIa，Fc Fragment Of IgG， Low Affinity IIIa， Receptor (CD16a)，CD16a Antigen，Fc Gamma Receptor IIIa，Fc-Gamma RIIIa，Fc-Gamma RIII，FcgammaRIIIA，FCGRIII，FcRIIIa，FCR-10，FCRIII，IMD20，CD16
研究＆開発段階	Phase 2 Clinical

英語名	Low affinity immunoglobulin gamma Fc region receptor III-A
ターゲットの別称	IGFR3，FCG3，Fc Fragment Of IgG， Low Affinity IIIa， Receptor For (CD16)，Fc Fragment Of IgG， Low Affinity III， Receptor For (CD16)，Immunoglobulin G Fc Receptor III，Fc-Gamma Receptor III-2 (CD 16)，Neutrophil-Specific Antigen NA，Fc-Gamma Receptor IIIb (CD16)，Fc Gamma Receptor III-A，Low Affinity Immunoglobulin Gamma Receptor III-A Fc Fragment，IgG Fc receptor III-2，Low affinity immunoglobulin gamma Fc region receptor III-A，FCGR3，CD16A，Fc-gamma RIII-alpha，FCGR3A，Fc Fragment Of IgG Receptor IIIa，Fc Fragment Of IgG， Low Affinity IIIa， Receptor (CD16a)，CD16a Antigen，Fc Gamma Receptor IIIa，Fc-Gamma RIIIa，Fc-Gamma RIII，FcgammaRIIIA，FCGRIII，FcRIIIa，FCR-10，FCRIII，IMD20，CD16
市販薬剤の数	0
治験薬の数	14
研究＆開発段階	Phase 2 Clinical

Fc gamma RIII / CD16 製品リスト

属性
Protein (5)
製品ライブラリ
オンライン (5)
種
Mouse (2)Cynomolgus (2)Rhesus macaque (1)
タグ
His Tag (3)His Tag & Avi Tag (2)
マーカー
Unconjugated (3)Biotin-labeled (2)

製品番号	種	発現システム	製品説明
HOT CDA-M52H8	Mouse	HEK293	Mouse Fc gamma RIII / CD16 Protein, His Tag (SPR & MALS verified)
HOT FC6-C52H9	Cynomolgus	HEK293	Cynomolgus Fc gamma RIII / CD16 Protein, His Tag (MALS & BLI verified)
HOT FC6-C82E0	Cynomolgus	HEK293	Biotinylated Cynomolgus Fc gamma RIII / CD16 Protein, His,Avitag™ (MALS & BLI verified)
FC6-M82E0	Mouse	HEK293	Biotinylated Mouse Fc gamma RIII / CD16 Protein, His,Avitag™ (MALS & SPR verified)
FC6-R52H6	Rhesus macaque	HEK293	Rhesus macaque Fc gamma RIII / CD16 Protein, His Tag (SPR & MALS verified)

総数量5

Fc gamma RIII / CD16バックグランド

CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibodydependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.

Fc gamma RIII / CD16分子の別称

FCGR3

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Acimtamig	AFM-13	Phase 2 Clinical	The University Of Texas MD Anderson Cancer Center	Hodgkin Disease; Lymphoma, B-Cell; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Mycosis Fungoides	詳細
IPH-6501	IPH-6501; IPH-65	Phase 2 Clinical	Innate Pharma SA	Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasms	詳細
FT-538	FT-538	Phase 2 Clinical	Fate Therapeutics Inc	Coronavirus Disease 2019 (COVID-19); Fallopian Tube Neoplasms; HIV Infections; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Respiratory Distress Syndrome, Adult; Solid tumours	詳細
GMA-161	GMA-161	Phase 1 Clinical	Macrogenics Inc, Sanofi	Purpura, Thrombocytopenic, Idiopathic	詳細
GTB-5550	GTB-5550; B7H3 TriKE™; cam1615B7H3; GTB-5550 TriKE™	Phase 1 Clinical	University Of Minnesota	Solid tumours	詳細
FT-576	FT-576	Phase 1 Clinical	Fate Therapeutics Inc, University Of Minnesota	Bone Marrow Neoplasms; Multiple Myeloma	詳細
AFM-28	AFM-28	Phase 1 Clinical	Affimed	Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Neoplasms	詳細
Donor-derived CD123-CD16 bispecific antibody-modified NK cells therapy(Chinese PLA General Hospital)		Phase 1 Clinical	Pla General Hospital	Leukemia, Myeloid, Acute	詳細
GTB-3650	GTB-3650; GTB-360; OXS-3350; OXS-C3550	Phase 1 Clinical	Masonic Cancer Center, University Of Minnesota	Bone Marrow Neoplasms; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes	詳細
BGB-B3227	BGB-B3227	Phase 1 Clinical	BeOne Medicines (Beijing) Co Ltd	Gastrointestinal Neoplasms; Lung Neoplasms; Neoplasm Metastasis; Neoplasms; Solid tumours	詳細
SM-3321	SM-3321; SM3321	Phase 1 Clinical	Zhuhai StarMab BioMed Technology Ltd	Leukemia, Myeloid, Acute; Neoplasms	詳細
FT-596	FT-596	Phase 1 Clinical	Fate Therapeutics Inc	Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin	詳細
SAR-443579	SAR-443579; SAR443579; SAR'579; IPH6101; IPH-6101	Phase 1 Clinical	Sanofi	Blastic Plasmacytoid Dendritic Cell Neoplasm; Hematologic Diseases; Leukemia, B-Cell; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma	詳細
FT-516	FT-516	Phase 1 Clinical	Fate Therapeutics Inc, University Of Minnesota	Abdominal Neoplasms; Coronavirus Disease 2019 (COVID-19); Fallopian Tube Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, B-Cell; Ovarian Neoplasms; Solid tumours	詳細