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Fc gamma RIIIA / CD16a

Fc gamma RIIIA / CD16a

Fc gamma RIIIA / CD16a 詳細

Molecule Name
Low affinity immunoglobulin gamma Fc region receptor III-A
分子の別称
FCGR3A,CD16A,FCG3,FCGR3,IGFR3
Drug Development Progress
治験薬の数14
市販薬剤の数0
研究＆開発段階Phase 2 Clinical
ターゲットの別称
IGFR3，FCG3，Fc Fragment Of IgG， Low Affinity IIIa， Receptor For (CD16)，Fc Fragment Of IgG， Low Affinity III， Receptor For (CD16)，Immunoglobulin G Fc Receptor III，Fc-Gamma Receptor III-2 (CD 16)，Neutrophil-Specific Antigen NA，Fc-Gamma Receptor IIIb (CD16)，Fc Gamma Receptor III-A，Low Affinity Immunoglobulin Gamma Receptor III-A Fc Fragment，IgG Fc receptor III-2，Low affinity immunoglobulin gamma Fc region receptor III-A，FCGR3，CD16A，Fc-gamma RIII-alpha，FCGR3A，Fc Fragment Of IgG Receptor IIIa，Fc Fragment Of IgG， Low Affinity IIIa， Receptor (CD16a)，CD16a Antigen，Fc Gamma Receptor IIIa，Fc-Gamma RIIIa，Fc-Gamma RIII，FcgammaRIIIA，FCGRIII，FcRIIIa，FCR-10，FCRIII，IMD20，CD16
バックグランド
CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody­dependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.

Fc gamma RIIIA / CD16a 製品リスト

Species
  • Human（7）
Tag
  • His Tag（3）
  • His Tag & Avi Tag（2）
  • His Tag & HSA Tag（1）
  • His Tag & SUMO Tag（1）
Host
  • HEK293（7）
Conjugate
  • Unconjugated（5）
  • Biotin-labeled（2）
Grade
  • RUO（7）
Low Endotoxin
  • No（7）
MoleculeCat. No.Product Name種HostStructurePurityActivitySize&Price
Fc gamma RIIIA / CD16a
HOTAvitag
CDA-H82E9
Biotinylated Human Fc gamma RIIIA / CD16a (V176) Protein, Avitag™,His Tag (SPR & MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISASPRBLI

$350.00

25ug
Fc gamma RIIIA / CD16a
HOT
CD8-H52H4
Human Fc gamma RIIIA / CD16a (V176) Protein, His Tag (SPR & MALS verified)
Human
HEK293
MALSSDS-PAGE
SPRBLI

$260.00

50ug
Fc gamma RIIIA / CD16a
HOT
CDA-H52H6
Human Fc gamma RIIIA / CD16a (F176, S197P) Protein, His Tag (MALS&SPR verified)
Human
HEK293
MALSSDS-PAGE
SPR

$360.00

100ug
Fc gamma RIIIA / CD16a
HOT
CDA-H5220
Human Fc gamma RIIIA / CD16a (F176) Protein, His Tag (MALS & SPR verified)
Human
HEK293
MALSSDS-PAGE
SPR

$260.00

50ug
Fc gamma RIIIA / CD16a
HOT
CDA-H52S1
Human Fc gamma RIIIA / CD16a (V176) Protein, HSA,His Tag (MALS & BLI verified)
Human
HEK293
MALSSDS-PAGE
BLI

$225.00

50ug
Fc gamma RIIIA / CD16a
CDA-H5290
Human Fc gamma RIIIA / CD16a (V176) Protein, SUMO,His Tag (MALS & BLI verified)
Human
HEK293
MALSSDS-PAGE
BLI

$225.00

50ug
Fc gamma RIIIA / CD16a
Avitag
CDA-H82E8
Biotinylated Human Fc gamma RIIIA / CD16a (F176) Protein, Avitag™,His Tag (SPR & MALS verified)
Human
HEK293
MALSSDS-PAGE
SPRBLI

$250.00

25ug
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抗体購入プラットフォーム

プロジェクトステージタイプ由来疾患領域適応症
CD16a VHH - 01PCCMonoclonalNanobodySolid TumorSolid tumor,Hematoma
プロジェクト
CD16a VHH - 01
ステージ
PCC
タイプ
Monoclonal
由来
Nanobody
疾患領域
Solid Tumor
適応症
Solid tumor,Hematoma
Resources

治験薬に関する情報

英語名研究コード研究開発ステージ会社適応症臨床試験
AcimtamigAFM-13Phase 2 ClinicalThe University Of Texas MD Anderson Cancer Center
Hodgkin Disease; Lymphoma, B-Cell; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Mycosis Fungoides
詳細
IPH-6501IPH-6501; IPH-65Phase 2 ClinicalInnate Pharma SA
Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasms
詳細
FT-538FT-538Phase 2 ClinicalFate Therapeutics Inc
Coronavirus Disease 2019 (COVID-19); Fallopian Tube Neoplasms; HIV Infections; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Respiratory Distress Syndrome, Adult; Solid tumours
詳細
GMA-161GMA-161Phase 1 ClinicalMacrogenics Inc, Sanofi
Purpura, Thrombocytopenic, Idiopathic
詳細
GTB-5550GTB-5550; B7H3 TriKE™; cam1615B7H3; GTB-5550 TriKE™Phase 1 ClinicalUniversity Of Minnesota
Solid tumours
詳細
FT-576FT-576Phase 1 ClinicalFate Therapeutics Inc, University Of Minnesota
Bone Marrow Neoplasms; Multiple Myeloma
詳細
AFM-28AFM-28Phase 1 ClinicalAffimed
Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Neoplasms
詳細
Donor-derived CD123-CD16 bispecific antibody-modified NK cells therapy(Chinese PLA General Hospital)Phase 1 ClinicalPla General Hospital
Leukemia, Myeloid, Acute
詳細
GTB-3650GTB-3650; GTB-360; OXS-3350; OXS-C3550Phase 1 ClinicalMasonic Cancer Center, University Of Minnesota
Bone Marrow Neoplasms; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes
詳細
BGB-B3227BGB-B3227Phase 1 ClinicalBeOne Medicines (Beijing) Co Ltd
Gastrointestinal Neoplasms; Lung Neoplasms; Neoplasm Metastasis; Neoplasms; Solid tumours
詳細
SM-3321SM-3321; SM3321Phase 1 ClinicalZhuhai StarMab BioMed Technology Ltd
Leukemia, Myeloid, Acute; Neoplasms
詳細
FT-596FT-596Phase 1 ClinicalFate Therapeutics Inc
Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin
詳細
SAR-443579SAR-443579; SAR443579; SAR'579; IPH6101; IPH-6101Phase 1 ClinicalSanofi
Blastic Plasmacytoid Dendritic Cell Neoplasm; Hematologic Diseases; Leukemia, B-Cell; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma
詳細
FT-516FT-516Phase 1 ClinicalFate Therapeutics Inc, University Of Minnesota
Abdominal Neoplasms; Coronavirus Disease 2019 (COVID-19); Fallopian Tube Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, B-Cell; Ovarian Neoplasms; Solid tumours
詳細
Customer Reviews
  • A***n2025-02-12
    Human Fc gamma RIIIA / CD16a (F176) Protein, His Tag (MALS & SPR verified)
    Acro's Fc gamma receptor proteins are my top choice for Octet binding assays. They consistently deliver reliable results, crucial for accurate research. Their product quality is outstanding, ensuring reproducible experiments. Acro's technical service is exceptional, with a responsive and knowledgeable support team. Their comprehensive range of well-characterized Fc receptor proteins, high purity, and bioactivity have made them my exclusive supplier. The attention to quality control ensures excellent batch-to-batch consistency.
  • W***u2024-10-08
    Biotinylated Human Fc gamma RIIIA / CD16a (V176) Protein, Avitag™,His Tag (SPR & MALS verified)
    We used this biotin labeled protein in the ELISA assay and we have got reproducible and high-quality results. Also I want to mention and there is no degradation or activity changes of this product over more than half year, which made it our experiment easier without bridging assay.
  • J***n2023-06-24
    Biotinylated Human Fc gamma RIIIA / CD16a (F176) Protein, Avitag™,His Tag (SPR & MALS verified)
    We used the biotinylated human Fc gamma RIIIA material from Acro to test the binding of different human antibodies. The material arrived quickly and in time for our experiments. I used the material with the Biacore 8K (SPR) instrument using Series S Biotin CAP chip. We were happy with how the material worked in this assay format. Overall, we were pleased with the quality and would recommend this to other researchers.
  • D***g2022-12-07
    Biotinylated Human Fc gamma RIIIA / CD16a (F176) Protein, Avitag™,His Tag (SPR & MALS verified)
    I have been using this product for screening antibody binding. The product showed satisfactory binding to streptavidin-coated beads, as well as satisfactory detection of an antibody control. I have also used a range of other biotinylated Fc gamma receptor products from Acro, which showed good binding to respective control antibodies, as well as stability at 4C when reconstituted (no compromised antibody binding results in a month).
  • 1***62019-10-16
    Human Fc gamma RIIIA / CD16a (F176) Protein, His Tag (MALS & SPR verified)
    We purchased several Fc receptor proteins. Our purpose is to test the binding affinity between antibodies and Fc receptors using Fortebio. Compared with products from other vendors, Acro's products have a higher purity and better bioactivity. Besides, their delivery is really fast. Looking forward to buying more products from ACRO in the future!