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Fc gamma RIIIA / CD16a

Fc gamma RIIIA / CD16a Overview

English Name	Low affinity immunoglobulin gamma Fc region receptor III-A	Approved Drugs	0
Drugs in Clinical Trials	14	Target Synonym	IGFR3，FCG3，Fc Fragment Of IgG， Low Affinity IIIa， Receptor For (CD16)，Fc Fragment Of IgG， Low Affinity III， Receptor For (CD16)，Immunoglobulin G Fc Receptor III，Fc-Gamma Receptor III-2 (CD 16)，Neutrophil-Specific Antigen NA，Fc-Gamma Receptor IIIb (CD16)，Fc Gamma Receptor III-A，Low Affinity Immunoglobulin Gamma Receptor III-A Fc Fragment，IgG Fc receptor III-2，Low affinity immunoglobulin gamma Fc region receptor III-A，FCGR3，CD16A，Fc-gamma RIII-alpha，FCGR3A，Fc Fragment Of IgG Receptor IIIa，Fc Fragment Of IgG， Low Affinity IIIa， Receptor (CD16a)，CD16a Antigen，Fc Gamma Receptor IIIa，Fc-Gamma RIIIa，Fc-Gamma RIII，FcgammaRIIIA，FCGRIII，FcRIIIa，FCR-10，FCRIII，IMD20，CD16
Highest Development Stage	Phase 2 Clinical

English Name	Low affinity immunoglobulin gamma Fc region receptor III-A
Target Synonym	IGFR3，FCG3，Fc Fragment Of IgG， Low Affinity IIIa， Receptor For (CD16)，Fc Fragment Of IgG， Low Affinity III， Receptor For (CD16)，Immunoglobulin G Fc Receptor III，Fc-Gamma Receptor III-2 (CD 16)，Neutrophil-Specific Antigen NA，Fc-Gamma Receptor IIIb (CD16)，Fc Gamma Receptor III-A，Low Affinity Immunoglobulin Gamma Receptor III-A Fc Fragment，IgG Fc receptor III-2，Low affinity immunoglobulin gamma Fc region receptor III-A，FCGR3，CD16A，Fc-gamma RIII-alpha，FCGR3A，Fc Fragment Of IgG Receptor IIIa，Fc Fragment Of IgG， Low Affinity IIIa， Receptor (CD16a)，CD16a Antigen，Fc Gamma Receptor IIIa，Fc-Gamma RIIIa，Fc-Gamma RIII，FcgammaRIIIA，FCGRIII，FcRIIIa，FCR-10，FCRIII，IMD20，CD16
Approved Drugs	0
Drugs in Clinical Trials	14
Highest Development Stage	Phase 2 Clinical

Fc gamma RIIIA / CD16a Product List

Product Category
Protein (7)Cell (5)Kits (2)
Product Status
Launched (14)
Species
Human (14)
Tag
His Tag (3)His Tag & Avi Tag (2)His Tag & SUMO Tag (1)HSA Tag & His Tag (1)- (7)
Conjugate
Unconjugated (5)Biotin-labeled (2)- (7)

Cat. No.	Species	Host	Product Description
HOT CD8-H52H4	Human	HEK293	Human Fc gamma RIIIA / CD16a (V176) Protein, His Tag (SPR & MALS verified)
HOT CDA-H5220	Human	HEK293	Human Fc gamma RIIIA / CD16a (F176) Protein, His Tag (MALS & SPR verified)
HOT CDA-H52H6	Human	HEK293	Human Fc gamma RIIIA / CD16a (F176, S197P) Protein, His Tag (MALS&SPR verified)
HOT CDA-H52S1	Human	HEK293	Human Fc gamma RIIIA / CD16a (V176) Protein, HSA,His Tag (MALS & BLI verified)
HOT CDA-H82E9	Human	HEK293	Biotinylated Human Fc gamma RIIIA / CD16a (V176) Protein, Avitag™,His Tag (SPR & MALS verified)
HOT SCJUR-STF067	Human	Jurkat	Human CD16a (158V) (Luc) Jurkat Reporter Cell
CDA-H5290	Human	HEK293	Human Fc gamma RIIIA / CD16a (V176) Protein, SUMO,His Tag (MALS & BLI verified)
CDA-H82E8	Human	HEK293	Biotinylated Human Fc gamma RIIIA / CD16a (F176) Protein, Avitag™,His Tag (SPR & MALS verified)
FRT-06	Human	-	Human Fc gamma RIIIA / CD16a (F176) binding Kit (TR-FRET)
FRT-07	Human	-	Human Fc gamma RIIIA / CD16a (V176) binding Kit (TR-FRET)

Total: 14

Fc gamma RIIIA / CD16a Background

CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibodydependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.

Fc gamma RIIIA / CD16a Synonyms

FCGR3A,CD16A,FCG3,FCGR3,IGFR3

Antibody Project Trading Platform

Project Name	Project Stage	Molecule Type	Molecule Source	Disease Area	Indication
CD16a VHH - 01	PCC	Monoclonal	Nanobody	Solid Tumor	Solid tumor,Hematoma

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Acimtamig	AFM-13	Phase 2 Clinical	The University Of Texas MD Anderson Cancer Center	Hodgkin Disease; Lymphoma, B-Cell; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Mycosis Fungoides	Details
IPH-6501	IPH-6501; IPH-65	Phase 2 Clinical	Innate Pharma SA	Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasms	Details
FT-538	FT-538	Phase 2 Clinical	Fate Therapeutics Inc	Coronavirus Disease 2019 (COVID-19); Fallopian Tube Neoplasms; HIV Infections; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Respiratory Distress Syndrome, Adult; Solid tumours	Details
GMA-161	GMA-161	Phase 1 Clinical	Macrogenics Inc, Sanofi	Purpura, Thrombocytopenic, Idiopathic	Details
GTB-5550	GTB-5550; B7H3 TriKE™; cam1615B7H3; GTB-5550 TriKE™	Phase 1 Clinical	University Of Minnesota	Solid tumours	Details
FT-576	FT-576	Phase 1 Clinical	Fate Therapeutics Inc, University Of Minnesota	Bone Marrow Neoplasms; Multiple Myeloma	Details
AFM-28	AFM-28	Phase 1 Clinical	Affimed	Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Neoplasms	Details
Donor-derived CD123-CD16 bispecific antibody-modified NK cells therapy(Chinese PLA General Hospital)		Phase 1 Clinical	Pla General Hospital	Leukemia, Myeloid, Acute	Details
GTB-3650	GTB-3650; GTB-360; OXS-3350; OXS-C3550	Phase 1 Clinical	Masonic Cancer Center, University Of Minnesota	Bone Marrow Neoplasms; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes	Details
BGB-B3227	BGB-B3227	Phase 1 Clinical	BeOne Medicines (Beijing) Co Ltd	Gastrointestinal Neoplasms; Lung Neoplasms; Neoplasm Metastasis; Neoplasms; Solid tumours	Details
SM-3321	SM-3321; SM3321	Phase 1 Clinical	Zhuhai StarMab BioMed Technology Ltd	Leukemia, Myeloid, Acute; Neoplasms	Details
FT-596	FT-596	Phase 1 Clinical	Fate Therapeutics Inc	Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin	Details
SAR-443579	SAR-443579; SAR443579; SAR'579; IPH6101; IPH-6101	Phase 1 Clinical	Sanofi	Blastic Plasmacytoid Dendritic Cell Neoplasm; Hematologic Diseases; Leukemia, B-Cell; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma	Details
FT-516	FT-516	Phase 1 Clinical	Fate Therapeutics Inc, University Of Minnesota	Abdominal Neoplasms; Coronavirus Disease 2019 (COVID-19); Fallopian Tube Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, B-Cell; Ovarian Neoplasms; Solid tumours	Details

Product Reviews

A***n2025-02-12
0People Like
Human Fc gamma RIIIA / CD16a (F176) Protein, His Tag (MALS & SPR verified)
Acro's Fc gamma receptor proteins are my top choice for Octet binding assays. They consistently deliver reliable results, crucial for accurate research. Their product quality is outstanding, ensuring reproducible experiments. Acro's technical service is exceptional, with a responsive and knowledgeable support team. Their comprehensive range of well-characterized Fc receptor proteins, high purity, and bioactivity have made them my exclusive supplier. The attention to quality control ensures excellent batch-to-batch consistency.
W***u2024-10-08
0People Like
Biotinylated Human Fc gamma RIIIA / CD16a (V176) Protein, Avitag™,His Tag (SPR & MALS verified)
We used this biotin labeled protein in the ELISA assay and we have got reproducible and high-quality results. Also I want to mention and there is no degradation or activity changes of this product over more than half year, which made it our experiment easier without bridging assay.
J***n2023-06-24
3People Like
Biotinylated Human Fc gamma RIIIA / CD16a (F176) Protein, Avitag™,His Tag (SPR & MALS verified)
We used the biotinylated human Fc gamma RIIIA material from Acro to test the binding of different human antibodies. The material arrived quickly and in time for our experiments. I used the material with the Biacore 8K (SPR) instrument using Series S Biotin CAP chip. We were happy with how the material worked in this assay format. Overall, we were pleased with the quality and would recommend this to other researchers.