FKBP12
FKBP12 詳細
| 英語名 | FK506-binding protein 1A | 市販薬剤の数 | 2 |
| 治験薬の数 | 5 | ターゲットの別称 | Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A，FK506-Binding Protein， T-Cell， 12-KD，FK506-Binding Protein 1A (12kD)，Protein Kinase C Inhibitor 2，FK506-Binding Protein 12，FK506 Binding Protein12，FK506-Binding Protein 1，FKBP12-Exip3，Calstabin 1，PPIASE，PKC12，PKCI2，Tacrolimus Binding Protein 1A，FKBP12C，FK506 Binding Protein 1A， 12kDa，12 KDa FK506-Binding Protein，Immunophilin FKBP12，12 KDa FKBP，Rotamase，FKBP Prolyl Isomerase 1A，FKBP1，FKBP12，FKBP-12，PPIase FKBP1A，FK506-binding protein 1A，Calstabin-1，FKBP-1A，FKBP1A，FK506 Binding Protein 1A |
| 研究＆開発段階 | Approved | ||
| 英語名 | FK506-binding protein 1A |
| ターゲットの別称 | Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A，FK506-Binding Protein， T-Cell， 12-KD，FK506-Binding Protein 1A (12kD)，Protein Kinase C Inhibitor 2，FK506-Binding Protein 12，FK506 Binding Protein12，FK506-Binding Protein 1，FKBP12-Exip3，Calstabin 1，PPIASE，PKC12，PKCI2，Tacrolimus Binding Protein 1A，FKBP12C，FK506 Binding Protein 1A， 12kDa，12 KDa FK506-Binding Protein，Immunophilin FKBP12，12 KDa FKBP，Rotamase，FKBP Prolyl Isomerase 1A，FKBP1，FKBP12，FKBP-12，PPIase FKBP1A，FK506-binding protein 1A，Calstabin-1，FKBP-1A，FKBP1A，FK506 Binding Protein 1A |
| 市販薬剤の数 | 2 |
| 治験薬の数 | 5 |
| 研究＆開発段階 | Approved |
FKBP12 製品リスト
- 属性
Protein (1)
- 製品ライブラリ
オンライン (1)
- 種
Human (1)
- タグ
His Tag (1)
- マーカー
Unconjugated (1)
| 製品番号 | 種 | 発現システム | 製品説明 | タンパク質の構造 | 純度 | 特性 |
|---|---|---|---|---|---|---|
 Human | E. coli | Human FKBP12 / FKBP1A Protein, His Tag |  |  |
総数量1
- 1
FKBP12バックグランド
Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus).FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.
FKBP12分子の別称
FKBP1A,FKBP1,Calstabin-1,FKBP12,Rotamase,PKC12,PPIASE
治験薬に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|
| MAM-1003-1 | MAM-1003-1 | Phase 2 Clinical | Marinomed Biotech AG | Conjunctivitis, Allergic; Rhinitis, Allergic | 詳細 |
| Tacrolimus (novaliq) | NOV-05; NOV05; BTQ2401; BTQ-2401 | Phase 2 Clinical | Novaliq Gmbh | Keratoconjunctivitis; Uveitis; Uveitis, Anterior; Xerophthalmia | 詳細 |
| Plerixafor/Tacrolimus Hydrate | MRG-001(MedRegen); AMD3100+FK506 | Phase 2 Clinical | MedRegen LLC | Abdominal Injuries; Amyotrophic Lateral Sclerosis; Coronavirus Disease 2019 (COVID-19); Cytokine Release Syndrome; Hepatitis, Alcoholic; Motor Neuron Disease; Respiratory Distress Syndrome, Adult; Respiratory Insufficiency; Respiratory Tract Diseases; Wounds and Injuries | 詳細 |
| Rimiducid | AP-1903 | Phase 2 Clinical | Ariad Pharmaceuticals Inc, Bellicum Pharmaceuticals Inc | Anemia, Aplastic; Anemia, Diamond-Blackfan; Anemia, Sickle Cell; Blastic Plasmacytoid Dendritic Cell Neoplasm; Bone Marrow Neoplasms; Colorectal Neoplasms; Congenital Bone Marrow Failure Syndromes; Cytopenia; Fanconi Anemia; Graft vs Host Disease; Hematologic Neoplasms; Hemoglobinopathies; Hodgkin Disease; Immune System Diseases; Immunoproliferative Disorders; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Lymphoid; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Lymphohistiocytosis, Hemophagocytic; Lymphoma; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Melanoma; Metabolic Diseases; Multiple Myeloma; Myelodysplastic Syndromes; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neoplasm, Residual; Neuroblastoma; Osteopetrosis; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Immunodeficiency Diseases; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Solid tumours; Thalassemia; Uveal melanoma | 詳細 |
| SQ-708 | SQ-708 | Phase 1 Clinical | Shenyang Xingqi Pharmaceutical Co Ltd | Keratoplasty rejection | 詳細 |
市販薬剤に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | オリジナル製品名 | 最初に承認をした国 | 最初の適応症 | 最初に承認を受けた会社 | 承認された日付 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|---|---|---|---|---|
| Tacrolimus Hydrate | FK-506; MR-4; RTU-007; LCP-Tacro; FR-900506; L-679934; FK-506MR; FK-506E | Approved | Astellas Pharma Inc | Protopy, Graceptor (as hydrate), TacroBell, Advagraf, Envarsus, Modigraf, Astagraf XL, Protopic, Prograf (as hydrate), Hecoria (as hydrate), Hexal, Envarsus XR, Talymus, 普乐可复 | United States | Rejection of liver transplantation; Rejection in heart transplantation; Rejection of renal transplantation | Astellas Pharma Us Inc | 1994-04-08 | Amputation, Traumatic; Arthritis, Rheumatoid; Asthma; Bone marrow transplant rejection; Brain Death; Burns; Colitis, Ulcerative; Conjunctivitis; Crohn Disease; Dermatitis, Atopic; Dermatomyositis; Dry Eye Syndromes; Edema; Encephalitis; Genital Diseases, Male; Glomerulonephritis, IGA; Graft vs Host Disease; Hamman-Rich Syndrome; Infertility, Female; Keratoconjunctivitis; Keratoconjunctivitis Sicca; Keratoplasty rejection; Kidney Diseases; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Liver Failure; Lung Diseases, Interstitial; Lupus Erythematosus, Cutaneous; Lupus Nephritis; Medication Adherence; Myasthenia Gravis; Myelodysplastic Syndromes; Nephrotic Syndrome; Ocular inflammation; Peripheral Nerve Injuries; Polymyositis; Primary Graft Dysfunction; Primary Myelofibrosis; Psoriasis; Pulmonary Arterial Hypertension; Rejection in heart transplantation; Rejection of renal transplantation; Rejection of liver transplantation; Rejection of lung transplantation; Rejecti | 詳細 |
| Pimecrolimus | SDZ-ASM-981; ASM-998; ASM-981 | Approved | Novartis Pharma Ag | Elidel | United States | Dermatitis, Atopic | Bausch & Lomb (Singapore) Pvi Ltd | 2001-12-13 | Dermatitis; Dermatitis, Atopic; Dermatitis, Perioral; Dermatitis, Seborrheic; Eczema; Exanthema; Keratoconjunctivitis Sicca; Lichen Planus, Oral; Netherton Syndrome; Pityriasis; Prurigo Nodularis; Vitiligo | 詳細 |
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