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FOLR1

FOLR1 詳細

英語名	Folate receptor alpha	市販薬剤の数	3
治験薬の数	27	ターゲットの別称	FRalpha，KB cells FBP，Adult folate-binding protein，Folate receptor 1，Folate receptor alpha，FR-alpha，FOLR1，Ovarian Tumor-Associated Antigen MOv18，Folate Receptor 1 (Adult)，Folate Receptor， Adult，FOLR，FBP，Folate Binding Protein，FRα
研究＆開発段階	Approved

英語名	Folate receptor alpha
ターゲットの別称	FRalpha，KB cells FBP，Adult folate-binding protein，Folate receptor 1，Folate receptor alpha，FR-alpha，FOLR1，Ovarian Tumor-Associated Antigen MOv18，Folate Receptor 1 (Adult)，Folate Receptor， Adult，FOLR，FBP，Folate Binding Protein，FRα
市販薬剤の数	3
治験薬の数	27
研究＆開発段階	Approved

FOLR1 製品リスト

属性
Protein (22)Cell (1)Antibody (1)
製品ライブラリ
オンライン (24)
種
Mouse (6)Cynomolgus / Rhesus macaque (4)Human (13)Rabbit (1)
タグ
His Tag (10)His Tag & Avi Tag (6)Fc Tag (4)Fc Tag & Avi Tag (2)- (2)
マーカー
Unconjugated (11)Biotin-labeled (8)FITC Labeled (1)PE Labeled (2)APC Labeled (1)- (1)

製品番号	種	発現システム	製品説明
HOT FO1-H5253	Human	HEK293	Human FOLR1 Protein, Fc Tag (Folic Acid Free, MALS verified)
HOT FO1-H52H1	Human	HEK293	Human FOLR1 Protein, His Tag (Folic Acid Free, MALS verified)
HOT FO1-H82E2	Human	HEK293	Biotinylated Human FOLR1 Protein, His,Avitag™ (Folic Acid Free, MALS verified)
HOT FO1-M82E9	Mouse	HEK293	Biotinylated Mouse FOLR1 Protein, His,Avitag™ (Folic Acid Free, MALS verified)
CHEK-ATP091	Human	HEK293	HEK293/Human FOLR1 Stable Cell Line
FO1-H5254	Human	HEK293	Human FOLR1 Protein, Fc Tag (Folic Acid Complex, MALS verified)
FO1-H52H3	Human	HEK293	Human FOLR1 Protein, His Tag, low endotoxin (Folic Acid Complex)
FO1-H82E3	Human	HEK293	Biotinylated Human FOLR1 Protein, His,Avitag™ (Folic Acid Complex, MALS verified)
FO1-H82F3	Human	HEK293	Biotinylated Human FOLR1 Protein, Fc,Avitag™ (Folic Acid Complex, MALS verified)
FO1-H82F9	Human	HEK293	Biotinylated Human FOLR1 Protein, Fc,Avitag™ (Folic Acid Free, MALS verified)

総数量24

FOLR1バックグランド

Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.

FOLR1分子の別称

FOLR-1,FBP,FOLR,FRα

抗体購入プラットフォーム

プロジェクト	ステージ	タイプ	由来	疾患領域	適応症
FRα BsAb - 01	PCC	Bispecific	Humanized Mouse,Nanobody	Solid Tumor	Ovarian cancer,Non-small cell lung cancer

ライセンシング

プロジェクト	薬物タイプ	治療分野	適応症	ステージ	エリア
FRα BsAb-ADC	Bispecific antibody	Oncology/Cancer	Ovarian cancer	Preclinical	Global

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Ricorfotide vedotin	CBP-1008	Phase 3 Clinical	Coherent Biopharma Suzhou Co Ltd	Breast Neoplasms; Carcinoma, Ovarian Epithelial; Carcinoma, Squamous Cell; Fallopian Tube Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Solid tumours	詳細
Arfolitixorin	ISO-901; 6R-MTHF	Phase 3 Clinical	Isofol Medical Ab	Colonic Neoplasms; Colorectal Neoplasms; Osteosarcoma; Rectal Neoplasms	詳細
Rinatabart Sesutecan	GEN1184; GEN-1184; PRO-1184	Phase 3 Clinical	ProfoundBio (Suzhou) Co Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cystadenocarcinoma, Serous; Endometrial Neoplasms; Fallopian Tube Neoplasms; Mesothelioma; Ovarian Neoplasms; Peritoneal Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Uterine Neoplasms	詳細
Sofetabart Mipitecan	LY4170156; LY-4170156	Phase 3 Clinical	Eli Lilly And Company, Loxo Oncology Inc	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Neoplasm Metastasis; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms	詳細
Torvutatug Samrotecan	AZD5335; AZD-5335	Phase 3 Clinical	Astrazeneca Plc	Adenocarcinoma of Lung; Carcinoma, Ovarian Epithelial; Endometrial Neoplasms; Fallopian Tube Neoplasms; Ovarian Neoplasms; Peritoneal Diseases; Solid tumours	詳細
BAT-8006	BAT8006; BAT-8006	Phase 3 Clinical	Bio-Thera Solutions Ltd	Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Solid tumours	詳細
Luveltamab tazevibulin	STRO-002	Phase 2 Clinical	Sutro Biopharma Inc	Carcinoma, Endometrioid; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Endometrial Neoplasms; Fallopian Tube Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Solid tumours	詳細
EB-NK-FM (FRalpha/MUC16)	EB-NK-FM	Phase 2 Clinical	Beijing Biotech	Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Peritoneal Neoplasms	詳細
EB-NK-MF (MSLN/FRalpha)	EB-NK-MF	Phase 2 Clinical	Beijing Biotech	Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Glioblastoma; Glioma; Peritoneal Neoplasms	詳細
18F-AzaFol	AzaFol; 18F-AzaFol; [18F]-AzaFol	Phase 2 Clinical	Insel Gruppe AG, University Hospital Bern	Giant Cell Arteritis; Lung Neoplasms; Neoplasms; Ovarian Neoplasms	詳細
Farletuzumab ecteribulin	MORAb-202	Phase 2 Clinical	Bristol-Myers Squibb Company, Eisai Co Ltd, Morphotek Inc	Carcinoma, Non-Small-Cell Lung; Ovarian Neoplasms; Solid tumours	詳細
4S-CAR-FRa	4S-CAR-FRa	Phase 2 Clinical	Shenzhen Geno-Immune Medical Institute	Carcinoma, Transitional Cell; Urinary Bladder Neoplasms	詳細
CBP-1019	CBP-1019	Phase 2 Clinical	Coherent Biopharma Suzhou Co Ltd	Breast Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Gastrointestinal Neoplasms; Lung Neoplasms; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Solid tumours; Thoracic Neoplasms; Urogenital Neoplasms	詳細
Noscapine-folate conjugate		Phase 1 Clinical	Emory University	Hematologic Neoplasms; Inflammation	詳細
MOv-18 IgE	MOv-18 IgE; MOv18; MOv-18	Phase 1 Clinical	Cancer Research UK, King'S College London	Neoplasms; Ovarian Neoplasms	詳細
MOv19-BBz CAR-T cells Therapy		Phase 1 Clinical	University Of Pennsylvania	Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms	詳細
ITIL-306	ITIL-306	Phase 1 Clinical	Instil Bio Inc	Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Genital Neoplasms, Female; Solid tumours	詳細
IMGN-151	IMGN-151	Phase 1 Clinical	Immunogen Inc	Breast Neoplasms; Cystadenocarcinoma, Serous; Endometrial Neoplasms; Fallopian Tube Neoplasms; Genital Neoplasms, Female; Ovarian Neoplasms; Peritoneal Neoplasms; Uterine Cervical Neoplasms	詳細
GenSci-140	GenSci140; GenSci-140	Phase 1 Clinical	Changchun GeneScience Pharmaceuticals Co Ltd	Ovarian Neoplasms; Solid tumours	詳細
IBI-3010	IBI-3010; IBI3010	Phase 1 Clinical		Neoplasm Metastasis; Solid tumours	詳細
SYS-6041	SYS6041; SYS-6041	Phase 1 Clinical	Jushi Biopharmaceutical Co Ltd	Neoplasms; Solid tumours	詳細
FH-FOLR1 Chimeric Antigen Receptor T Cell Therapy(Fred Hutchinson Cancer Center)		Phase 1 Clinical	Fred Hutchinson Cancer Research Center	Leukemia, Myeloid, Acute; Osteosarcoma	詳細
[177Lu]Lu-EVS459	GIZ943; GIZ-943; [177Lu]Lu-EVS459; EVS-459	Phase 1 Clinical	Novartis Pharma Ag	Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Ovarian Neoplasms	詳細
ZW-191	ZW-191	Phase 1 Clinical	Zymeworks Inc	Carcinoma, Non-Small-Cell Lung; Genital Neoplasms, Female; Ovarian Neoplasms; Solid tumours	詳細
AMT-151	AMT-151	Phase 1 Clinical	Multitude Therapeutics Inc	Adenocarcinoma of Lung; Adenocarcinoma, Clear Cell; Carcinoma, Endometrioid; Carcinoma, Ovarian Epithelial; Carcinoma, Pancreatic Ductal; Endometrial Neoplasms; Fallopian Tube Neoplasms; Mesothelioma; Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	詳細
UB-TT170	UB-TT-170; UB_TT170; UB_TT-170; UB-TT170	Phase 1 Clinical	Umoja BioPharma Inc	Osteosarcoma	詳細
CBP-1018	CBP-1018	Phase 1 Clinical	Coherent Biopharma Suzhou Co Ltd	Carcinoma, Renal Cell; Lung Neoplasms; Prostatic Neoplasms; Solid tumours	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Pafolacianine Sodium	Pteroyl-L-Tyr-S0456; OTL-38; EC-17; OTL-0038	Approved	On Target Laboratories Inc	Cytalux	United States	Ovarian Neoplasms	On Target Laboratories Inc	2021-11-29	Arthritis, Rheumatoid; Breast Neoplasms; Esophageal Neoplasms; Gastrointestinal Neoplasms; Genital Neoplasms, Female; Inflammatory Bowel Diseases; Lung Neoplasms; Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Pituitary Neoplasms	詳細
Mirvetuximab soravtansine	M9346-Asulfo-SPDB-DM4; IMGN-853; M9346A-sSPDB-DM4; TAK-853; HDM2002; HDM-2002	Approved	Immunogen Inc	Elahere, 爱拉赫	United States	Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Fallopian Tube Neoplasms	Immunogen Inc	2022-11-14	Adenocarcinoma, Clear Cell; Breast Neoplasms; Carcinoma, Ovarian Epithelial; Carcinosarcoma; Cystadenoma, Serous; Endometrial Neoplasms; Fallopian Tube Diseases; Fallopian Tube Neoplasms; Neoplasms; Ovarian Neoplasms; Peritoneal Diseases; Peritoneal Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Uterine Neoplasms	詳細
Folinic Acid	FTHF	Approved							Anemia; Autism Spectrum Disorder; Colorectal Neoplasms; Diarrhea; Down Syndrome; Rectal Neoplasms; Vitamin B 12 Deficiency	詳細

レビュー

p***g2025-01-23
0評価
Human FOLR1 Protein, His Tag (Folic Acid Free, MALS verified)
As expected, this was a high quality product. I have purchased multiple products from Acro to develop assays in the past. As usual, purity and quantity was confirmed by our in-house quality control group. We are using this in conjunction with #FO1-H82E2 Biotinylated Human FOLR1 Protein, His Avitag. The product was used successfully in an immunization campaign and will also be used for other in-house assays in the future.
D***m2022-10-26
0評価
Human FOLR1 Protein, His Tag (Folic Acid Free, MALS verified)
We had to order human folate receptor protein for 100 micrograms unit type for one of our sensitive studies. It was crucial that the product work as intended. We received the product in a timely manner, and the product work as intended for one of our studies. As an employee working at a lab, I thank you for all the scientists working hard to make great products!
D***n2022-10-26
0評価
Human FOLR1 Protein, His Tag (Folic Acid Free, MALS verified)
We had previously ordered this product and we made the mistake of ordering the smaller quantity needed. We contacted customer support letting them know that we needed to switch the order to the larger quantity. They were friendly and helpful when resolving this issue. After the switch, the item in question was sent out very quickly and we were able to continue with our study as soon as it arrived.