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Frizzled-2

Frizzled-2 詳細

英語名	Frizzled-2	市販薬剤の数	0
治験薬の数	1	ターゲットの別称	Frizzled Class Receptor 2，Frizzled 2， Seven Transmembrane Spanning Receptor，Frizzled Family Receptor 2，FzE2，Fz-2
研究＆開発段階	Phase 1 Clinical

英語名	Frizzled-2
ターゲットの別称	Frizzled Class Receptor 2，Frizzled 2， Seven Transmembrane Spanning Receptor，Frizzled Family Receptor 2，FzE2，Fz-2
市販薬剤の数	0
治験薬の数	1
研究＆開発段階	Phase 1 Clinical

Frizzled-2 製品リスト

属性
Protein (2)
製品ライブラリ
オンライン (2)
種
Human (2)
タグ
Fc Tag (2)
マーカー
Unconjugated (2)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
FZ2-H5251	Human	HEK293	Human Frizzled-2 / FZD2 Protein, Fc Tag
FZ2-H5255	Human	HEK293	Human Frizzled-2 / FZD2 (24-190) Protein, Fc Tag

総数量2

Frizzled-2バックグランド

Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.

Frizzled-2分子の別称

FZD2,Frizzled-2,Fz-2,hFz2,FzE2

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Vantictumab	OMP-18R5; anti-Fzd7	Phase 1 Clinical	Bayer AG, Oncomed Pharmaceuticals Inc	Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Osteopetrosis; Pancreatic Neoplasms; Solid tumours	詳細