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Frizzled-4

Frizzled-4 Overview

English Name	Frizzled-4	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	hFz4，FzE4，CD344，Frizzled 4， Seven Transmembrane Spanning Receptor，Fz-4，Frizzled Family Receptor 4，EVR1，Frizzled (Drosophila) Homolog 4，Frizzled Homolog 4 (Drosophila)，Exudative Vitreoretinopathy 1，WNT Receptor Frizzled-4，Frizzled Homolog 4，CD344 Antigen，FZD4S，FEVR，GPCR，Fz4
Highest Development Stage	Phase 3 Clinical

English Name	Frizzled-4
Target Synonym	hFz4，FzE4，CD344，Frizzled 4， Seven Transmembrane Spanning Receptor，Fz-4，Frizzled Family Receptor 4，EVR1，Frizzled (Drosophila) Homolog 4，Frizzled Homolog 4 (Drosophila)，Exudative Vitreoretinopathy 1，WNT Receptor Frizzled-4，Frizzled Homolog 4，CD344 Antigen，FZD4S，FEVR，GPCR，Fz4
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 3 Clinical

Frizzled-4 Product List

Product Category
Protein (2)
Product Status
Launched (2)
Species
Human (2)
Tag
Fc Tag (1)His Tag & Avi Tag (1)
Conjugate
Unconjugated (1)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
FZ4-H5250	Human	HEK293	Human Frizzled-4 / FZD4 Protein, Fc Tag
FZ4-H82E3	Human	HEK293	Biotinylated Human Frizzled-4 / FZD4 Protein, His,Avitag™ (MALS verified)

Total: 2

Frizzled-4 Background

Frizzled-4 (FZD4) is also known as FzE4, CD344, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD4 contains one FZ (frizzled) domain. FZD4 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD4 interacts with MAGI3 and norrin (NDP).