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FUS

FUS 詳細

英語名	RNA-binding protein FUS	市販薬剤の数	0
治験薬の数	2	ターゲットの別称	75 kDa DNA-pairing protein，Fused in Sarcoma protein，Translocated in liposarcoma protein，POMp75，Oncogene TLS，Oncogene FUS
研究＆開発段階	Phase 3 Clinical

英語名	RNA-binding protein FUS
ターゲットの別称	75 kDa DNA-pairing protein，Fused in Sarcoma protein，Translocated in liposarcoma protein，POMp75，Oncogene TLS，Oncogene FUS
市販薬剤の数	0
治験薬の数	2
研究＆開発段階	Phase 3 Clinical

FUS 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
His Tag & MBP Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
FUS-H5144	Human	E. coli	Human FUS Protein, MBP,His Tag

総数量1

FUSバックグランド

FUS (RNA-binding protein FUS) is a DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. It binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. It binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. FUS plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, FUS plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis.

FUS分子の別称

75 kDa DNA-pairing protein,ALS6,amyotrophic lateral sclerosis 6,FUS1,fused in sarcoma,fus-like protein,Oncogene FUS,Oncogene TLS,RNA-binding protein FUS,POMP75,Translocated in liposarcoma,Translocated in liposarcoma protein

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Ulefnersen	ION-363	Phase 3 Clinical	Ionis Pharmaceuticals Inc	Amyotrophic Lateral Sclerosis	詳細
RAG-21	RAG-21	Phase 1 Clinical	Ractigen Therapeutics (Nantong) Co Ltd	Amyotrophic Lateral Sclerosis	詳細