言語を選択

GAD1

GAD1 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
His Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
GA1-H5543	Human	InsectCells	Human GAD1 / GAD67 Protein, His Tag

総数量1

GAD1バックグランド

Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA), the major inhibitory transmitter in higher brain regions, and putative paracrine hormone in pancreatic islets. GAD uses pyridoxal-phosphate (PLP) as a cofactor.Two molecular forms of GAD (65 kDa and 67 kDa) are highly conserved and both are expressed in the CNS, pancreatic islet cells, testis, oviduct and ovary. The isoforms are regionally distributed cytoplasmically in the brains of rats and mice. GAD65 is an ampiphilic, membrane-anchored protein (585 a.a.), and is responsible for vesicular GABA production. GAD67 is cytoplasmic (594 a.a.), and seems to be responsible for significant cytoplasmic GABA production.

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Dapirolizumab pegol	Anti-CD40L-Fab; Anti-CD40L-Fab-PEG; CDP-7657; CD40L - Fab; BIIB-133	Phase 3 Clinical	Biogen Inc, Ucb	Autoimmune Diseases; Connective Tissue Diseases; Immune System Diseases; Lupus Erythematosus, Systemic; Skin and Connective Tissue Diseases	詳細
Dazodalibep	VIB-4920; MEDI-4920; HZN-4920(Horizon Therapeutics); UNII-HN5US76BWF; WHO-11399	Phase 3 Clinical	Medimmune Llc, Horizon Therapeutics PLC	Rejection of renal transplantation; Sjogren's Syndrome; Arthritis, Rheumatoid; Lupus Nephritis; Rejection of organ transplantation; Sjogren-Larsson Syndrome	詳細
Frexalimab	INX-021; SAR-441344	Phase 3 Clinical	Immunext Inc	Diabetes Mellitus, Type 1; Sjogren's Syndrome; Multiple Sclerosis; Lupus Erythematosus, Systemic; Glomerulosclerosis, Focal Segmental; Sjogren-Larsson Syndrome; Glomerulonephritis	詳細
Anti-CD40L antibody (Bristol-Myers Squibb)		Phase 2 Clinical	Bristol-Myers Squibb Company	Immunologic Deficiency Syndromes	詳細
AdCD40L		Phase 2 Clinical	Uppsala University	Urinary Bladder Neoplasms; Melanoma	詳細
Tegoprubart	AT-1501	Phase 2 Clinical	Als Therapy Development Institute	Diabetes Mellitus, Type 1; Rejection of renal transplantation; Glomerulonephritis, IGA; Diabetes Mellitus; Amyotrophic Lateral Sclerosis	詳細
Delolimogene mupadenorepvec	LOAd-703	Phase 2 Clinical	Uppsala University, Lokon Pharma	Biliary Tract Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Colorectal Neoplasms; Melanoma	詳細
CD40 ligand expressing MSLN-CAR T cells		Phase 2 Clinical	Pla General Hospital	Solid tumours	詳細
CD40L-augmented Tumor Infiltrating Lymphocytes (H Lee Moffitt Cancer Center & Research Institute)		Phase 2 Clinical	H Lee Moffitt Cancer Center & Research Institute	Carcinoma, Non-Small-Cell Lung	詳細
Letolizumab	BMS-986004; BMS2h-572-633-CT-L2	Phase 1 Clinical	Bristol-Myers Squibb Company	Purpura, Thrombocytopenic, Idiopathic; Graft vs Host Disease	詳細
TNX-1500	TNX-1500	Phase 1 Clinical	Tonix Pharmaceuticals Holding Corp	Autoimmune Diseases; Rejection of organ transplantation; Autoimmune Diseases of the Nervous System	詳細
MEM-288	MEM-288	Phase 1 Clinical	Memgen	Solid tumours; Head and Neck Neoplasms; Carcinoma, Merkel Cell; Neoplasms; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Melanoma	詳細
IBI355	IBI-355	Phase 1 Clinical	Innovent Biologics(Suzhou) Co Ltd	Sjogren's Syndrome; Lupus Erythematosus, Systemic	詳細
APB-A1	APB-A1; Lu-AG22515	Phase 1 Clinical	AprilBio Co Ltd	Graves Ophthalmopathy; Neuromyelitis Optica	詳細