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GAD2

GAD2 詳細

英語名	Glutamate decarboxylase 2	市販薬剤の数	0
治験薬の数	1	ターゲットの別称	EC 4.1.1.15，GAD65，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kD)，Glutamate Decarboxylase-2 (Pancreas)，EC:4.1.1.15，EC 4.1.1，Glutamate decarboxylase 65 kDa isoform，65 kDa glutamic acid decarboxylase，GAD2，Glutamate Decarboxylase 2，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kDa)，GAD-65
研究＆開発段階	Pending

英語名	Glutamate decarboxylase 2
ターゲットの別称	EC 4.1.1.15，GAD65，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kD)，Glutamate Decarboxylase-2 (Pancreas)，EC:4.1.1.15，EC 4.1.1，Glutamate decarboxylase 65 kDa isoform，65 kDa glutamic acid decarboxylase，GAD2，Glutamate Decarboxylase 2，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kDa)，GAD-65
市販薬剤の数	0
治験薬の数	1
研究＆開発段階	Pending

GAD2 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
His Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
GA2-H55H3	Human	InsectCells	Human GAD2 / GAD65 Protein, His Tag

総数量1

GAD2バックグランド

Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA), the major inhibitory transmitter in higher brain regions, and putative paracrine hormone in pancreatic islets. GAD uses pyridoxal-phosphate (PLP) as a cofactor.Two molecular forms of GAD (65 kDa and 67 kDa) are highly conserved and both are expressed in the CNS, pancreatic islet cells, testis, oviduct and ovary. The isoforms are regionally distributed cytoplasmically in the brains of rats and mice. GAD65 is an ampiphilic, membrane-anchored protein (585 a.a.), and is responsible for vesicular GABA production. GAD67 is cytoplasmic (594 a.a.), and seems to be responsible for significant cytoplasmic GABA production.