GDNF
GDNF 詳細
| 英語名 | Glial cell line-derived neurotrophic factors | 市販薬剤の数 | 0 |
| 治験薬の数 | 5 | ターゲットの別称 | Glial Cell Line-Derived Neurotrophic Factors |
| 研究＆開発段階 | NDA/BLA | ||
| 英語名 | Glial cell line-derived neurotrophic factors |
| ターゲットの別称 | Glial Cell Line-Derived Neurotrophic Factors |
| 市販薬剤の数 | 0 |
| 治験薬の数 | 5 |
| 研究＆開発段階 | NDA/BLA |
GDNF 製品リスト
- 属性
Protein (5)Kits (1)
- 製品ライブラリ
オンライン (6)
- 種
Human (5)Mouse (1)
- タグ
Tag Free (4)His Tag (1)- (1)
- マーカー
Unconjugated (5)- (1)
| 製品番号 | 種 | 発現システム | 製品説明 | タンパク質の構造 | 純度 | 特性 |
|---|---|---|---|---|---|---|
HOT GMP-GDFH17 |  Human | E. coli | GMP Human GDNF Protein (E. coli) |  |  |  |
| Human | E. coli | Human GDNF / ATF / hGDNF Protein (E. coli), premium grade |  | | | |
| Human | E. coli | Human GDNF / ATF / hGDNF Protein (E. coli), Research Grade |  | |  | |
| Human | HEK293 | Human GDNF / ATF / hGDNF Protein, premium grade |  | | | |
| Human | - | resDetect™ GDNF ELISA kit (Residue Testing) | ||||
 Mouse | HEK293 | Mouse GDNF / ATF Protein, His Tag, low endotoxin (MALS verified) |  | |
総数量6
- 1
GDNFバックグランド
Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. The GDNF family members (consists of GDNF, neurturin, artemin and persephin) are structurally similar to transforming growth factor-beta. Unlike other members of the TGF-beta superfamily, which signal through the receptor serine-threonine kinases, GDNF family ligands activate intracellular signalling cascades via the receptor tyrosine kinase Ret. GDNF family ligands binds to GDNF family receptor alpha (GFRalpha) and then the GDNF family ligand-GFR alpha complex binds to and stimulates autophosphorylation of Ret.
GDNF分子の別称
GDNF,ATF
治験薬に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|
| AB-1005 | AMT-140; AB-1005; AAV2-GDNF; AAV2-GDNF-MSA; AAV2-GDNF-PD | Phase 2 Clinical | Uc San Francisco | Multiple System Atrophy; Parkinson Disease | 詳細 |
| NRO-1 | NRO-1; SI-01 | Phase 2 Clinical | Senju Pharmaceutical Co Ltd | Xerophthalmia | 詳細 |
| Ifezuntirgene inilparvovec | AAV5-miSNP15; AMT-130; AAV5-miHtt12; AAV5-miSNP7 | Phase 2 Clinical | Amsterdam Molecular Therapeutics, Uniqure | Huntington Disease | 詳細 |
| AAV2-GDNF gene therapy (NINDS) | Phase 1 Clinical | National Institute Of Neurological Disorders And Stroke | Parkinson Disease | 詳細 | |
| RGL-193 | RGL-193 | Phase 1 Clinical | Shanghai Regenelead Therapies Co Ltd | Parkinson Disease | 詳細 |
レビュー
P***i2025-05-13
0評価Acro Biosystems' GDNF recombinant protein has proven to be a reliable and high-quality reagent for research focused on neuronal development and maturation. In my study involving cortical projection neuron cultures, GDNF consistently supported neuronal survival, neurite outgrowth, and the expression of maturation markers. Its batch-to-batch consistency and biological activity have made it an essential component in our differentiation protocols. I highly recommend this product to laboratories engaged in both fundamental neuroscience research and translational studies aiming to model neurodegenerative diseases or explore neuroprotective strategies.
- 詳細
- 製品リスト
- レビュー
- 治験薬に関する情報