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GITR

GITR 詳細

英語名	Glucocorticoid-induced tumor necrosis factor receptor-related protein	市販薬剤の数	0
治験薬の数	4	ターゲットの別称	TNFRSF18，TNF Receptor Superfamily Activation-Inducible Protein，ENERGEN，GITR-D，Tumor Necrosis Factor Receptor Superfamily Member 18，CD357 Antigen，Activation-Inducible TNFR Family Receptor，AITR，CD357，GITR，Glucocorticoid-Induced TNFR-Related Protein，Tumor Necrosis Factor Receptor Superfamily， Member 18，TNF Receptor Superfamily Member 18
研究＆開発段階	Phase 2 Clinical

英語名	Glucocorticoid-induced tumor necrosis factor receptor-related protein
ターゲットの別称	TNFRSF18，TNF Receptor Superfamily Activation-Inducible Protein，ENERGEN，GITR-D，Tumor Necrosis Factor Receptor Superfamily Member 18，CD357 Antigen，Activation-Inducible TNFR Family Receptor，AITR，CD357，GITR，Glucocorticoid-Induced TNFR-Related Protein，Tumor Necrosis Factor Receptor Superfamily， Member 18，TNF Receptor Superfamily Member 18
市販薬剤の数	0
治験薬の数	4
研究＆開発段階	Phase 2 Clinical

GITR 製品リスト

属性
Protein (7)
製品ライブラリ
オンライン (7)
種
Human (4)Canine (1)Mouse (2)
タグ
His Tag (3)Fc Tag (1)Fc Tag & Avi Tag (1)His Tag & Avi Tag (2)
マーカー
Unconjugated (4)Biotin-labeled (3)

製品番号	種	発現システム	製品説明
HOT GIR-H5228	Human	HEK293	Human GITR / TNFRSF18 Protein, His Tag, low endotoxin (MALS verified)
HOT GIR-H5254	Human	HEK293	Human GITR / TNFRSF18 Protein, Fc Tag, low endotoxin
GIR-H82E5	Human	HEK293	Biotinylated Human GITR / TNFRSF18 Protein, His,Avitag™ (MALS verified)
GIR-H82F7	Human	HEK293	Biotinylated Human GITR / TNFRSF18 Protein, Fc,Avitag™
GIR-M52H3	Mouse	HEK293	Mouse GITR / TNFRSF18 Protein, His Tag
GIR-M82E3	Mouse	HEK293	Biotinylated Mouse GITR / TNFRSF18 Protein, His,Avitag™ (MALS verified)
GIR-C52H6	Canine	HEK293	Canine GITR / TNFRSF18 Protein, His Tag

総数量7

GITRバックグランド

Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.

GITR分子の別称

AITR,GITR,TNFRSF18,CD357

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
BMS-986156	BMS-986156	Phase 2 Clinical	Bristol-Myers Squibb Company	Liver Neoplasms; Lung Neoplasms; Neoplasms; Solid tumours; Thoracic Neoplasms	詳細
Ragifilimab	INCAGN-1876; INCAGN-01876; AGEN-1876; CM-701	Phase 2 Clinical	Agenus Inc, Ludwig Institute For Cancer Research	Neoplasm Metastasis; Neoplasms	詳細
Anti-GITR antibody (BMS)		Phase 1 Clinical	Bristol-Myers Squibb Company	Neoplasms	詳細
IBI-102	IBI102; IBI-102	Phase 1 Clinical		Neoplasms	詳細

レビュー

1***32019-09-27
1評価
Human GITR / TNFRSF18 Protein, His Tag, low endotoxin (MALS verified)
I have been using Acro's products for a long time. Whenever there is some concerns on product or technical support is needed, it always gets solved in time. I used the GITR protein for SPR experiments. I have done 6 concentration gradients, and the fitted curve was still very good. The data also met my expectations. I hope we will continue having a good cooperation with ACRO moving forward.