Glycoprotein G (HeV)

Glycoprotein G (HeV) 製品リスト

  • 属性

    Protein (1)Antibody (2)

  • 製品ライブラリ

    オンライン (3)

  • Hendra virus (1)Mouse (2)

  • タグ

    His Tag (1)- (2)

  • マーカー

    Unconjugated (3)

Glycoprotein G (HeV)バックグランド

Hendra virus (HeV) and Nipah virus (NiV) are henipaviruses discovered in the mid-to late 1990s that possess a broad host tropism and are known to cause severe and often fatal disease in both humans and animals. HeV and NiV infect host cells through the coordinated efforts of two envelope glycoproteins. The G glycoprotein attaches to cell receptors, triggering the fusion (F) glycoprotein to execute membrane fusion. G is a type II homotetrameric transmembrane protein responsible for binding to ephrinB2 or ephrinB3 (ephrinB2/B3) receptors. F is a homotrimeric type I transmembrane protein that is synthesized as a premature F0 precursor and cleaved by cathepsin L during endocytic recycling to yield the mature, disulfide-linked, F1 and F2 subunits. Upon binding to ephrinB2/B3, NiV G undergoes conformational changes leading to F triggering and insertion of the F hydrophobic fusion peptide into the target membrane. Subsequent refolding into the more stable post-fusion F conformation drives merger of the viral and host membranes to form a pore for genome delivery to the cell cytoplasm.

治験薬に関する情報

英語名研究コード研究開発ステージ会社適応症臨床試験
CXCR5 Modified EGFR Chimeric Antigen Receptor Autologous T Cell TherapyPhase 1 ClinicalSecond Affiliated Hospital Of Guangzhou Medical UniversityCarcinoma, Non-Small-Cell Lung
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